I work with Win98se and would like to permanently move my swap file to
another physical drive. I have read various posts on the web about
this and have tried to do it but Windows continues to insist it be on
C:.

I believe this is the solution to slow and balky mouse response. When
I go into the performance adjustments in properties and change the
swap to another drive there is an instantaneous improvement in
response. It lasts only a few minutes and when I go back to the
performance window Windows has returned to its default, 'let windows
manage virtual memory' setting. I have tired to do it and immediately
reboot, no difference.

Right click on MY Computer and goto >properties > Performance >
virtual memory and change the setting form letting window handle it to
letting you customize.  Then you can change to D:\ using the little
down arrow by "hard disk"
Also, set the maximum amount of virtual memory to 2.5 times the amount
physical RAM. Set the minimum for 5 meg less.
Click OK twice. 
Shut down and restart your computer.

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Clarification of Answer by nellie_bly-ga on 06 Nov 2002 11:38 PST

If the change doesn't "stick,"  try removing the swapfile and then
resetting.

Change setting to "disable virtual memory" and reboot.  You'll get
dire warnings that doing this will cause the world to end, but go
ahead any way.
It may boot into safe mode. That's ok.  Then immediately go back and
set your virtual memory to the new drive and size and reboot, again.

just checking -- is your second drive fully installed and recognized
by your bios and Windows? If you're accessing it freely now, that
answers the question.

just a performance tip, since it's kind of related; you may want to
add a virtual cache in the system.ini file similar to this:

[vcache]
MinFileCache=2048
MaxFileCache=32768

you can read more about how to set it(what the # values should be) if
you do a search on the web.