![]() |
|
![]() | ||
|
Subject:
Mouse Tumor Models
Category: Science > Biology Asked by: greatone100-ga List Price: $2.00 |
Posted:
24 Nov 2002 13:14 PST
Expires: 03 Dec 2002 14:02 PST Question ID: 113771 |
Spontaneous mouse tumor models can be created by: a. transgenic mice technology b. knocking out tumour suppressor genes c. UV radiation d. Feeding mice carcinogens Can be more than one correct answer |
![]() | ||
|
There is no answer at this time. |
![]() | ||
|
Subject:
Re: Mouse Tumor Models
From: tehuti-ga on 24 Nov 2002 18:14 PST |
All four approaches could lead to tumors. However, I would not call the induction of tumors with carcinogens or with UV a "spontaneous" tumor model, because it is deliberate induction with a known tumorigenic agent. I'm loath to put this in as an answer, because it really depends on the view taken by your lecturer as what is meant by "spontaneous". |
Subject:
Re: Mouse Tumor Models
From: unstable-ga on 26 Nov 2002 01:05 PST |
agree with tehuti that u probably need to check with your lecturer what he/she means by spontaneous. but obviously a and b is out, becos they specifically create cancer (i.e. not spontaneous at all) for uv and carcinogens, it depends on the dosage, it is pseudo-spontaneous, if you expose the poor mouse to continual tumorigenic agents sooner or later they would develop tumors, i guess you can call them spontaneous in the sense that you sometimes cannot determine what type of tumors would occur..although by and large uv agents usually trigger some type of skin cancer tumors and the chemicals are more likely to trigger the liver cancer type tumors. |
Subject:
Re: Mouse Tumor Models
From: tehuti-ga on 26 Nov 2002 02:16 PST |
Actually, I meant it the other way round. Mouse b would have missing some of the normal control mechanisms which prevent the occurrence of tumours, and mouse a could be engineered to have a fault in others. Therefore, these mice would develop tumours spontaneously without any specific treatment on the part of the experimenter. By asking what is meant by spontaneous, I was thinking along the lines that, for example, inducing tumours with UV light mimics a process that one might or might not call spontaneous when it happens in real life. |
If you feel that you have found inappropriate content, please let us know by emailing us at answers-support@google.com with the question ID listed above. Thank you. |
Search Google Answers for |
Google Home - Answers FAQ - Terms of Service - Privacy Policy |