Spinal Cord Injury
Category: Science > Biology
Asked by: greatone100-ga
List Price: $2.00
26 Nov 2002 13:14 PST
Expires: 26 Dec 2002 13:14 PST
Question ID: 115036
Which of the following is/are NOT components of primary spinal cord injury? (there can be more than one correct answer) a. compression b. herniated disc c. contusion d. glutamate release e. laceration due to fracture f. mechanical disruption of blood vessels g. both a & c h. both b & d i. All are related to primary injury
Re: Spinal Cord Injury
Answered By: synarchy-ga on 03 Dec 2002 02:43 PST
Hi All of the answers which you have listed can be components of primary spinal cord injury. "primary" spinal cord injury occurs from processes which directly injure the components of the spinal cord. Lacerations, compressions (from a herniated disc or blunt trauma), disruption of blood vessels are all mechanisms for injuring the spinal cord. Glutamate release occurs with primary injury (although this is often only mentioned in secondary injury) and is thought to contribute to secondary injury, via excitotoxic cell death, along with ischemia (lack of blood flow), swelling, and other sequela which can result from the initial injury. A nice page from eMedicine describing spinal cord injuries. Search for "primary SCIs": http://www.emedicine.com/EMERG/topic553.htm This page contains a fairly thorough Q&A format discussion of spinal cord injuries: http://www.cureparalysis.org/faq/ Another good page describing spinal injury - mentions the glutamate excitotoxicity topic. http://www.genpat.uu.se/persons/faro/intro.html Another page describing spinal cord injury and including a list of mechanisms for primary spinal cord injury (the discussion of secondary injury is brief however) (original page is unresponsive but the 'view as html' link works) http://126.96.36.199/search?q=cache:rHf0Ple3dgQC:188.8.131.52/er119/sked/conspineread.doc+%22primary+spinal+cord+injury%22+mechanism&hl=en&ie=UTF-8 search strategy: Google: "primary spinal cord injury" mechanism Google: primary "spinal injury" "glutamate release"
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