Experimental bone tumor metastatic models are created by injecting the
cancer cell via: (there may be more than one correct answer)
a. tail vein
b. left heart ventricle
c. subcutaneous
d. a & b

Hi -

All of the mentioned routes of administration have been used. 
Intravenous injections of cells is the most common way of modeling the
metastatic cancer.  Other approaches involve injection into bones (the
femur usually), body cavities, the heart or by subcutaneous
implantation of foreign tissue (non cancerous) followed by
intravenous/intragraft injections of cancer cells (the tissue
presumably serves a site for the cells to grow).

This page describes current work on bone tumor metastatic models
including intravenous injections, injections into the femoral cavity,
and implantation:
http://www.karmanos.org/we/research/prostate/model.html

This rather long paper describes an approach injecting the cells
directly into bone:
http://www.techtransfer.wayne.edu/98-449NPD.doc

This paper uses an intracardiac injection:
http://virology.med.uoc.gr/IJO/2002/volume20/number2/299-303.pdf

This paper uses subcutaneous injections:
http://www.artp.org/pros-tum/BAS_pt27e.htm



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