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Q: medical research ( Answered,   1 Comment )
Subject: medical research
Category: Health > Medicine
Asked by: arnulfo-ga
List Price: $2.00
Posted: 27 Dec 2002 09:13 PST
Expires: 26 Jan 2003 09:13 PST
Question ID: 133927
effect of mixing flomax, fiorinal, and celebrex
Subject: Re: medical research
Answered By: kevinmd-ga on 28 Dec 2002 21:12 PST
Thanks for asking your question.  I am an internal medicine physician,
and I will answer factual medical questions - please consult with your
primary care physician for questions regarding individual cases.

You asked the following:
"effect of mixing flomax, fiorinal, and celebrex" - I assume you are
referring to drug interactions.

I used 2 tools to determine this - they both returned the same

1) Epocrates Multicheck
"MultiCheck allows you to quickly check for multiple drug interactions
simultaneously. This feature is integrated with our proprietary drug
interactions database to provide you with concise and
clinically-relevant drug interactions."

typing in "flomax, fiorinal (which is a combination of aspirin 325mg,
codeine 40mg and butalbital 50mg), and celebrex":

Multicheck shows an interaction between fiorinal and celebrex:
"caution advised, combo may increase risk of GI bleeding, GI adverse

2) PDRŽ Electronic Library™ Drug Interactions
"This useful tool checks for drug-to-drug interactions cited in the
PDR database. Simply enter the names of two or more drugs (either by
brand or generic name). In minutes, MerckMedicus displays the critical
interaction information that you and your patients need to know."

typing in "flomax, aspirin/codeine/butalbital (which is what fiorinal
is comprised of), and celebrex":

PDR shows and interaction between celebrex and aspirin (one of the
components of fiorinal):
"Celebrex Capsules (Pfizer) Celecoxib 

may interact with: 

Aspirin Regimen Bayer Regular Strength 325 mg Caplets (Bayer Consumer)

Results: (Co-administration may result in an increased rate of GI
ulceration or other complications; low dose of aspirin can be used
with celecoxib)"

There were no interactions between the flomax and the other

Please use any answer clarification before rating this answer.  I will
be happy to explain or expand on any issue you may have. 
Kevin, M.D.
Subject: Re: medical research
From: pinkfreud-ga on 28 Dec 2002 17:52 PST
Taking Celebrex and Fiorinal together may cause stomach problems.
Fiorinal contains aspirin, and it is not advisalbe to use Celebrex
concomitantly with aspirin or other non-steroidal anti-inflammatory

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