Hello tom136-ga,
I was able to find quite a lot of information for you on the
bioadhesives technology market. Bioadhesives are a sub-category of the
drug delivery products and systems market. These are research
intensive industries and there are many players. Developers of
biomaterials frequently partner with pharmaceutical companies who then
market their materials under proprietary product names. I’ve grouped
the information I’ve found under headings that should help you make a
productive analysis of the raw information.
Good luck on your explorations.
czh
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BIOADHESIVES – MATERIALS AND RESEARCH
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http://www.pharmanet.com.br/pdf/drugdelivery.pdf
Current Status of Drug Delivery Technologies and Future Directions
Verma RK, Garg S. Current status of drug delivery technologies and
future directions. Pharm Tech. On-line 2001; 25(2):1-14.
This is a 14 page report that presents a very good overview of the
topic.
http://www.aapspharmsci.org/scientificjournals/pharmsci/journal/99_13.html
http://www.pharmsci.org/scientificjournals/pharmsci/journal/99_13.html
Evaluation of Polyoxyethylene Homopolymers for Buccal Bioadhesive Drug
Delivery Device Formulations
http://www.courses.ahc.umn.edu/medical-school/BMEn/5001/notes/adhesion.html
Polymers as Chemical and Biological Adhesives
Biological Adhesion - can mean different things
1. An adhesive is used to join two biological tissues
2. To stick something to skin (Band-aid, transdermal drug delivery
system...)
3. Mucosal drug delivery
4 Tissue adhesives
Bioadhesive polymers for the peroral delivery of peptide drugs
Bioadhesive polymers - multifunctional macromolcules which are able to
increase the permeability of epithelial tissues and to simultaneously
inhibit proteolytic enymes. By virtue of mucoadhesive properties these
polymers make close contact to mucosa, thereby exerting such effects
at locally high concentrations in a confined area.
http://www.purdue.edu/OOP/SciCo/promis.html
Purdue University researchers have developed a new type of material
that sticks to the skin and can deliver controlled doses of drugs to
wounds, speeding the healing process.
http://matilde.ashley-pub.com/vl=18044968/cl=40/nw=1/rpsv/cw/apl/14712598/v2n3/s6/p287
Expert Opinion on Biological Therapy
2002, vol. 2, no. 3, pp. 287 - 298
Developments in the area of bioadhesive drug delivery systems
Abstract
This paper aims to review the current progress in bioadhesion for drug
delivery applications as well as new techniques related to this field.
Research started with mucoadhesive polymers that had already been in
use as excipients and were rapidly used in new formulations. Their
major drawback was found in their unspecific binding, as they adhere
to almost any mucosal surface. As some of the polymers showed
additional properties such as enzyme inhibition and permeation
enhancement, however, they remain interesting as multifunctional
excipients. In contrast to mucoadhesion, the concept of specific
bioadhesion by use of lectins and other adhesion molecules is now
gaining increasing attention as these substances bind directly to
receptors on the cell surface rather than to the mucus gel layer.
Since specific binding to the cell surface is often followed by uptake
and intracellular transport, new chances for drug delivery evolved.
Bioadhesion may, thus, enable researchers to deliver macromolecular
drugs directly to specific target cells and has implications also
relevant to other fields of science, such as tissue engineering, gene
delivery and nanotechnology.
Ashley Publications – Full text available by subscription
http://pubs.acs.org/cen/coverstory/8034/8034drugdelivery.html
DRUG DELIVERY
Materials scientists look for new materials and ways to manipulate
existing ones in order to fulfill unmet needs
Bioadhesive polymers to help improve the absorption of drugs are the
focus of work by Edith Mathiowitz, an associate professor of medical
science and engineering at Brown University. "You can find
applications for bioadhesive polymers in almost any region that you
have epithelial cells," she says, including oral, buccal (cheek), GI
tract, rectal, or vaginal delivery. "The adhesive molecules bring the
delivery system closer to the mucosa. If the particle is larger than
10 mm in diameter, it will stay for a prolonged time and deliver the
drug. If the particle is small, the chances of being taken up are much
higher. In the last case, the entire delivery system with the drug is
delivered to the systemic circulation."
Mathiowitz has started a company called Spherics to commercialize the
polymeric drug delivery systems.
http://www.ualberta.ca/~csps/JPPS1(1)/A.Shojaei/buccalreview.htm
http://www.ualberta.ca/~csps/JPPS1(1)/A.Shojaei/Shojaei.pdf
Buccal Mucosa As A Route For Systemic Drug Delivery: A Review
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BIOADHESIVES AND DRUG DELIVERY -- INDUSTRY AND MARKET
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http://www.datamonitor.com/~dd685e2d29e749258ffbbf7bc8e9f180~/healthcare/capsules/markets/product.asp?pid=1CA1AD1B-7D7A-4328-A731-7998F539F97B
United States - Transmucosal Drug Delivery Systems
Market Overview
The market was worth $3.6 billion in 2001. This value is expected to
grow consistently, reaching a value of $52.9 billion in 2006. This
represents a CAGR of 7.6%.
Market Definition
The transmucosal drug delivery systems market refers to the
development, manufacture and sale of pharmaceutical products which
incorporate transmucosal drug delivery technologies. This includes
drug delivery which uses the full range of absorptive mucosae,
including buccal, nasal; pulmonary, rectal and vaginal. The market
value is calculated from the overall sales revenues generated by
companies that operate in this market.
See additional sections
Industry Overview Competitive Landscape Leading Companies
Related Industries Companies in this Sector Free PDF Version
http://www.newsletters.com/product/display.asp?productID=144750
The Bio-Adhesives Market in the United States: 1999-2005
Marketing Research Bureau Inc - 1/1/2000 - 120 Pages - ID: MRB01
Countries Covered: United States
US $4,950.00
Abstract: Since the market introduction of "Tisseel" and "Hemaseel
APR" in 1998, a number of companies have intensified or redirected
their efforts to develop a fibrin sealant product or other
bioadhesives; they will soon compete in specific surgical areas. Among
them are: Alpha Therapuetic, the American Red Cross, Aventis Behring,
Cohesion Corporation, ConvaTec, Cryolife, Focal, Fusion Medical,
Marine Polymer Technologies, Nycomed Amersham, PPL Therapeutics,
Protein Polymer Technologies, Quadrant Corporation and Thermogenesis.
http://www.mindbranch.com/listing/ph-drde.html
Market Research Publications
http://www.mindbranch.com/catalog/product.jsp?code=R313-1428&display=toc
United States Transmucosal Drug Delivery Systems - Market Profile
Market Report, 10 pages, $100
http://www.dresources.com/DR/Reports.nsf/BrowseAbstracts/6F3C6315D8DA461886256B57007463F7?OpenDocument
Drug Delivery: Market Drivers, Technologies, and Companies
Study # 03, 1/1/2002, 74 pages
In this report, we review five “products to watch” because of their
potential impact on the industry. The industry is now valued at more
than $40 billion and promises to be the fastest-growing segment of the
pharmaceutical industry.
This report provides an overview of drug delivery technologies,
industry trends, market drivers, competitive strategies, key products,
and profiles of leading companies in the drug delivery industry. We
include an overview of alliances and acquisitions to enable greater
understanding of industry dynamics and insight into future directions
for consolidation within this sector.
http://atlas.pharmalicensing.com/features/disp/1007461802_3c0ca5aa0a428
Drug Delivery Technologies: Innovations and market challenges
Scrip Reports
Published: May 2001
Pages: 231
Ref: BS1086E
Price: £595/$1,250/„143,000
Drug Delivery is one of the fastest growing healthcare sectors, with
sales of drugs incorporating drug delivery systems increasing at an
annual rate of 15%. By 2003, the US drug delivery market alone will be
worth $24 billion.
The drug delivery companies themselves and pharmaceutical companies
who partner them are poised to reap the rewards of the estimated $40
billion drug delivery market, which is forecast to grow to $70 billion
by 2005.
The drug delivery arena is highly research intensive – in this report
alone, the collective product pipeline for drug delivery based
products exceeds 350 products across 10 routes of delivery including
oral, transmucosal, transdermal, inhalational, carrier/liposomal,
injectable/implantable, targeted/site-specific, chronotherapeutic,
gene delivery, and ocular delivery.
http://www.rapra.net/bookstore/displaycontents.asp?bid=p139m
Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches and
Developments
Drugs and the Pharmaceutical Sciences Series, Volume 98
Hard-backed, 626 pages
US$258.00
http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=55
Articles: Treatment Options Gel With Innovative Drug Delivery Systems
The BEMA™ technology is based on multi-layer films comprised of
bioerodible polymers that are listed in the FDA’s Inactive Ingredient
Guide. The drug (which can be a small molecule or a polypeptide) is
incorporated into the bioadhesive layer, which contacts the buccal
mucosa.
http://www-2.hoovers.com/industry/description/0,2205,5130,00.html
Drugs - Drug Delivery Systems
Companies engaged in the formulation and development of drug delivery
technologies, including oral transmucosal, liquid effervescence,
bioadhesive, pulmoner systems, transdermal, and softgels. See also:
Drug Manufacturers - Major; Drug Manufacturers – Other
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SAMPLE OF BIOADHESIVES COMPANIES
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http://www.columbialabs.com/
The Bioadhesive Delivery System consists principally of a polymer,
polycarbophil, and an active ingredient. The Bioadhesive Delivery
System is based upon the principle of bioadhesion, a process by which
the polymer adheres to epithelial surfaces and to mucin, a naturally
occurring secretion of the mucous membranes. The polymer remains
attached to epithelial surfaces and/or the mucin and is discharged
upon normal cell turnover or upon the detachment of the mucin from the
mucous membranes, a physiological process which, depending upon the
area of the body, occurs every 12 to 72 hours. This extended period of
attachment permits the Bioadhesive Delivery System to be utilized in
products when extended duration of effectiveness is desirable or
required.
http://www.mc.vanderbilt.edu/histo/BasicTissue/Epith.Definition.html
Epithelial tissue is the basic tissue which covers surface areas: the
spaces, surfaces and the cavities of the body.
There are three types of epithelial tissues:
Covering and lining
Glandular
Sensory
http://www.kvpharmaceutical.com/about/default.htm
KV Pharmaceutical Company
In 1990, KV established ETHEX Corporation to develop and market
generic drugs that could benefit from the application of KV's drug
delivery technologies. In 1999, KV established Ther-Rx Corporation to
develop and market branded prescription products utilizing these
proprietary technologies as well. Today, KV offers 14 drug delivery
technologies, in four principal areas, used in most of the company's
more than 80 generic and seven branded drugs that are sold today.
http://www.spherics.com/matriarch/OnePiecePage.asp?PageID=86&PageName=AboutSpherics
Spherics has developed three complementary bioadhesive-based drug
delivery technologies:
http://www.biogeltech.com/index.html
Biogel Technology, Inc.is a research-driven company which specializes
in applying the technologies of polymer science to controlled
delivery, separations, biomaterials, bioadhesives and related areas.
http://www.atrixlabs.com/compinfo/coinfo.cfm
Atrix is a multiple opportunities drug delivery and drug development
company. With five excellent patented technologies, Atrix specializes
in non-oral drug delivery--providing parenteral, transmucosal, and
topical delivery of proteins, peptides, and small molecules with the
goal of making pharmaceutical products more effective and more patient
friendly with less side effects.
http://www.alpharx.com/index.html
AlphaRx is an emerging pharmaceutical company specializing in the
formulation of therapeutic products using proprietary drug delivery
technologies. AlphaRx's core competent is in the development of novel
drug formulations for compounds that are otherwise insoluble or poorly
soluble in water. Bioadhesive Colloidal Dispersion™ drug delivery
technologies
http://www.noveoninc.com/
Noveon, Inc. is a global producer of specialty polymers, polymer-based
formulations and chemical additives for consumer and industrial
products.
http://www.pharma.noveoninc.com/products/performance_excipients.asp
Noveon, Inc. polymers are the industry standard for bioadhesive
applications, that include those for oral bioadhesive applications and
topical bioadhesive applications. Noveon® polycarbophils, Carbopol®
polymers, and Pemulen® polymeric emulsifiers offer innovative
opportunities in novel drug delivery systems where mucous membranes
are targeted, including ophthalmic, buccal, nasal, intestinal, vaginal
and rectal applications.
http://www.cryolife.com/products.htm
According to industry estimates, surgical adhesives address an annual
worldwide market of $2 billion. BioGlue is the easiest to use surgical
adhesive, capable of being assembled by the operating room staff in
less than a minute.
http://www.psivida.com.au/news/download/Press/dd.pdf
pSivida Limited is an Australian listed public company (ASX: PSD)
Drug Delivery Industry
See Table giving breakdown of expected market size for each method for
year 2005
http://www.stockselector.com/allinind.asp?indnumber=513
Drug Delivery – List of Companies
Innovative companies whose purpose is to design and develop new ways
to introduce drugs to the body. These new methods may consist of
time-released capsules, differing injection techniques, or enabling
certain drugs to be taken orally that may not have been to be taken so
before. Their revenue is obtained from selling their technology to
pharmaceutical companies or licensing it to manufacturers of
prescription drugs.
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PUBLICATIONS AND GENERAL RESOURCES
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http://www.drugdeliverytech.com/index.shtml
Drug Delivery Technology Magazine
http://www.drugdeliverytech.com/ad2.shtml
Market Forecast for Drug Delivery Industry
http://www.drugdel.com/
Drugdel.com is an information resource website for professionals
working in the field of drug delivery. Our target audience includes
Scientists and Engineers working in the Pharmaceutical industry and
Academia, as well as business analysts and technical specialists
serving the pharmaceutical and biotechnology sector.
http://www.pharmaportal.com/pharmaportal/
Advanstar Pharmaceutical Publications
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