I am currently taking celexa.  Recently I read that wellbutrin could
help my sex drive.
Is it safe to take these two together?

Good morning, maggiemoon!

The "Doctor's Answers to Frequently Asked Questions" had this to say
about wellbutrin and celexa together:

"Question: i would like to know if wllbutrin and celexa have any
adverse effects when used together.

Answer: Not usually, but needs to be monitored by an md."

Drug Infonet
[ http://www.druginfonet.com/faq/new/DRUG_FAQ/Wellbutrin.htm ]

The Celexa Fact Sheet notes that Celexa is known for fewer instances
of drug interactions:

"How does Celexa interact with other medications?

Like other SSRIs, Celexa should not be taken with monoamine oxidase
inhibitors (MAOIs). Although Celexa is noted for its reduced instances
of drug interactions, you should always let your doctor know what
other medications you are taking. "

Celexa Fact Sheet
[ http://www.nami.org/helpline/celexa.html ]

Wellbutrin is not on the list of drugs known to interact badly with
Celexa:

Celexa Drug Monograph
[ http://www.mentalhealth.com/drug/p30-c04.html#Head_5 ]

...nor is Celexa on Wellbutrin's list of offenders:

Wellbutrin Drug Monograph
[ http://www.mentalhealth.com/drug/p30-b04.html#Head_6 ]

I hope this answers your question!

missy-ga

Perfect.... Did a lot of the finger work I didn't have time for.

Please take this commentary as a purely personal opinion, this is not
official advice.

In short, do NOT combine the two medications without consulting your
md first.

The relevant information in this case is, that the neurochemical
mechanism of the antidepressant effect of bupropion (Wellbutrin) is
not known. So you can not deduct any interactions.
Keep in mind that Celexa as a selective serotonine reuptake inhibitor
and wellbutrin (that shows signs to block the neuronal uptake of
serotonine) could cause unwanted additive effects.

Maggiemoon-ga:

Celexa (citalopram), like other selective serotonin reuptake
inhibitors (SSRIs), can often induce unwanted sexual side effects in
those who are taking them.  Unlike other bothersome secondary effects
such as dry mouth, nausea, insomnia, headache, and diarrhea -- sexual
dysfunction normally does not resolve with continued use of the
medication.  SSRI-induced sexual dysfunction typically manifests
itself as delayed orgasm, in both males and females, or anorgasm,
which is the inability to achieve orgasm/ejaculation.

Wellbutrin (bupropion), is unique in that it does not specifically
inhibit the reuptake of serotonin in the central nervous system. 
There are other mechanisms involved, including inhibiting
norepinephrine uptake, another neurotransmitter.  As a result, sexual
dysfunction with bupropion is not very common.  Therefore, it is
possible for individuals who are using a SSRI to be switched to
Wellbutrin with fairly good results in sexual functioning.

The one caveat is that SSRIs may have other indications for their use,
such as general anxiety disorder, that bupropion is not indicated for.
 For this reason, if you have any history of anxiety or are using
Celexa for an anxiety or post-traumatic stress disorder (PTSD),
bupropion may exacerbate these symptoms and should not be used.

If you are still interested in adding Wellbutrin to your Celexa
therapy, there have been studies that show augmentation therapy could
be successful although there is a risk of a possible drug-drug
interaction, mainly serotonin syndrome.

The following is the citation for the study:

Ashton AK, Rosen RC.  Bupropion as an Antidote for Serotonin Reuptake
Inhibitor-Induced Sexual Dysfunction.  J Clin Psychiatry
1998;59:112-115

This study showed that taking bupropion 75mg 1 to 2 hours prior to
anticipated sexual activity was successful in many patients with
regards to reversing SSRI-induced sexual dysfunction.  Other patients
tried bupropion 75mg three times daily with similar results.

In the clinic where I currently practice pharmacy, we use
cyproheptadine, an inexpensive antihistamine with serotonergic
blocking properties, to treat SSRI-induced sexual dysfunction.  I
recommend cyproheptadine 4 to 8 mg 1 hour prior to anticipated sexual
activity.  It appears to work well for our clients.  However, using it
on a daily basis may block the anti-depressant effects of the SSRI.