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Subject:
CDT Results in Blood Chemistry Profile/Lab Results
Category: Health Asked by: kgirouard-ga List Price: $10.00 |
Posted:
04 Mar 2003 09:22 PST
Expires: 03 Apr 2003 09:22 PST Question ID: 170508 |
I had a blood test recently by an independent laboratory for insurance purposes. I keep all copies of my blood work for the past 6 years. When looking over their results to past blood work results by other labs, I noticed that something called "CDT" was tested and it said "CDT results confirmed by Western Blot Assay." My doctor was also unfamiliar with "CDT" and called his lab (perhaps I need to get a new doctor). I believe it is called Carb Deficit Transfer or something. COuld you please tell me what CDT is and why I might have been tested for this? Thanks |
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Subject:
Re: CDT Results in Blood Chemistry Profile/Lab Results
Answered By: pinkfreud-ga on 04 Mar 2003 09:41 PST |
CDT is "Carbohydrate Deficient Transferrin." Many insurance companies use a CDT test to check for possible alcohol abuse in potential clients. "In the 1990s, two new tests were introduced into life insurance medicine. They came to be known as alcohol markers, earning this moniker because they were shown to have very high specificity for abusive drinking. These two tests are known as carbohydrate-deficient transferrin (CDT) and hemoglobin-associated acetaldehyde (HAA)... In a recent informal survey of 30 major companies, this underwriter found that 1 in 3 did not make use of alcohol markers as yet. There are probably a number of reasons for this, one of which is the fact that these tests are not yet widely utilized in health care. That may change, however, now that one version of the CDT test has been approved by the Food and Drug Administration for clinical use." MyAssurenet http://www.myassurenet.com/articles/hgeorge1100.html "There are also 'special blood tests' that are used to clarify cases of SAA [suspected alcohol abuse]. One of these is the CDT ( see this link for a description and how it is used in SAA cases http://www.labone.com/insurance/cdt.html )" Risk Tutor http://www.risktutor.com/demo/dec_01.html "Carbohydrate-deficient transferrin (CDT) is an effective tool in the search for the chronic alcohol abuser. The CDT test is performed on serum samples in cases of suspected alcohol abuse. When elevated, CDT can be indicative of chronic, excessive consumption of alcohol, defined as at least 60 grams of alcohol per day on a routine basis for a minimum of two or three weeks... Other causes of an elevated CDT measurement include biliary cirrhosis and obstructive liver disease. " Lab One http://www.labone.com/insurance/cdt.html Search terms used: cdt blood test carbohydrate deficient transferrin alcohol abuse insurance I hope this is helpful. If anything I've said is unclear or incomplete, if more information is required, or if any of the links do not function, please request clarification before rating my answer; I'll be glad to offer further assistance. Best regards, pinkfreud |
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Subject:
Re: CDT Results in Blood Chemistry Profile/Lab Results
From: xarqi-ga on 04 Mar 2003 11:41 PST |
Just FYI: The "Western blot" is a widespread technique for detecting the presence of, and to some extent measuring the concentration of, a protein of interest, in this case CDT. It works by separating proteins from a sample according to their molecular weight by passing them through a gel (usually acrylamide) under the influence of an electric current. The separated proteins are then transferred to a membrane (just like a sheet of plastic really), either PVDF or nitrocellulose, where they are immobilised (this is the "blotting" step. Note that they are still spread out according to their molecular weight. Then, an antibody that is specific for the protein of interest is applied, and this is detected, usually by attaching ANOTHER antibody to it that carries a useful enzyme. This enzyme is used to cause a reaction that either colours the membrane, or causes light to be emitted. The combination of the position of the signal on the membrane, a function of the molecular weight, and the specificity of the antibody pretty much identifies the protein of interest. The strength of the signal is a measure (albeit coarse) of protein concentration. BTW - it is called "Western" by analogy with the "Southern" blot - a similar process for the detection of particular DNA segments - developed by E. M. Southern. Thee is also Northern blotting for RNA, and far-western blotting! So far - no Eastern blotting - (carbohydrates maybe??) |
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