Could you find some peer-reviewed articles (example: Pediatric
journals) no more than 5 years old on this topic that talks about the
condition, incidence, prevalence, treatment options, and expected
prognosis?

---

Request for Question Clarification by kutsavi-ga on 21 Mar 2003 21:43 PST

Hi there Shotie, 

If you could clarify a couple of points, it would make our job as
researchers easier ;-)

1. How many articles are you looking for; 5? 10? More?  
2. Also, most journals charge a subscription fee to view their
articles.  Abstracts can sometimes but not always be found on line. 
Are you looking for full text articles or abstracts, or would the
title and journal edition, date, volume, etc. be sufficient for you so
you could look them up at a library?

Thanks!
--Kutsavi

---

Clarification of Question by shotie48-ga on 22 Mar 2003 13:25 PST

Dear Kutsavi-ga,  Thanks for getting back to me.  If you are unable to
find full-text peer-reviewed medical/pediatric articles, listing the
details (title, author(s), vol., journal, page no., and mo/year would
be greatly appreciated.  They cannot be more than 5 years old.  I do
not have a minimum or maximum number of references that I have to have
as long as it contains the facts I asked in my first request.

Thank You, Shotie

---

Request for Question Clarification by librariankt-ga on 22 Mar 2003 15:38 PST

Hi Shotie48,

I did a cursory search of the PubMed MEDLINE database for the
following search and found approximately 300 results: ((((("purpura,
thrombocytopenic, idiopathic"[MeSH Terms] OR Idiopathic
thrombocytopenia purpura[Text Word]) AND hasabstract[text]) AND
(("infant"[MeSH Terms] OR "child"[MeSH Terms]) OR "adolescent"[MeSH
Terms])) AND (("human"[MeSH Terms] OR "hominidae"[MeSH Terms]) OR
"Human"[MeSH Terms])) AND ("1997"[PDat] : "2003"[PDat])).

Basically, it's using these ideas:
idiopathic thrombocytopenia purpurea
in children (infant, child, adolescent)
in humans (as opposed to animal studies)
in articles with abstracts (a good indication, usually, of peer
reviewal)
published in the years 1997 to 2003

I'm thinking that 300 will be too many for you, but I'm not sure how
to narrow down the search further given the information you've
supplied.  If you'd like, I can try to give you a direct link to these
results (it can be tricky to construct it correctly for PubMed).  If
that would satisfy your search, please let me know.

I want to warn you, as Kutsavi did above, that very few of these will
be available on the Internet for free.  However, they all have
citation information and abstracts which you should fee free to
browse.

Thanks for your guidance!

librariankt

---

Request for Question Clarification by librariankt-ga on 22 Mar 2003 15:41 PST

I should add that the database allows searching on the following
subheadings:

blood 
chemically induced 
classification 
complications 
congenital 
diagnosis 
diet therapy 
drug therapy 
economics 
embryology 
enzymology 
epidemiology 
ethnology 
etiology 
genetics 
history 
immunology 
metabolism 
microbiology 
mortality 
nursing 
parasitology 
pathology 
physiopathology 
prevention and control 
psychology 
radiography 
radionuclide imaging 
radiotherapy 
surgery 
therapy 
ultrasonography 
veterinary 
virology 

If you'd like to pick out one or more of these to include in the
search (for example, "incidence" and "prevalence" aren't good options
- but "epidemiology" might be close) I can try to narrow the results
down using these subheading terms.

librariankt

---

Request for Question Clarification by librariankt-ga on 22 Mar 2003 15:53 PST

Hi Shotie48,

Sorry for all of the clarifications, you've piqued my interest...

I looked in PubMedCentral, which is a free, online repository of
peer-reviewed journals in medicine and health, and found the following
four articles for you:

Pharmacokinetics of Cefepime during Continuous Renal Replacement
Therapy in
Critically Ill Patients.
Malone RS, Fish DN, Abraham E, Teitelbaum I.
Antimicrob Agents Chemother.  2001 Nov; 45(11): 3148-3155.
PMCID: 90796
[PubLink]  

Longitudinal Analysis of Lymphocyte Function and Numbers in the First
Year
of Life in Chromosome 22q11.2 Deletion Syndrome (DiGeorge
Syndrome/Velocardiofacial Syndrome).
Sullivan KE, McDonald-McGinn D, Driscoll DA, Emanuel BS, Zackai EH,
Jawad AF.
Clin Diagn Lab Immunol.  1999 Nov; 6(6): 906-911.
PMCID: 95796
[PubLink]  

Recent Advances in Determining the Pathogenesis of Canine Monocytic
Ehrlichiosis.
Harrus S, Waner T, Bark H, Jongejan F, Cornelissen AW.
J Clin Microbiol.  1999 Sep; 37(9): 2745-2749.
PMCID: 85367
[PubLink]  

Pharmacokinetics of Levofloxacin and Ciprofloxacin during Continuous
Renal
Replacement Therapy in Critically Ill Patients.
Malone RS, Fish DN, Abraham E, Teitelbaum I.
Antimicrob Agents Chemother.  2001 Oct; 45(10): 2949-2954.
PMCID: 90762
[PubLink]  

To get to these, go to the PMC database:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Text&DB=pmc and
enter "idiopathic thrombocytopenia purpura" in the search box.  You
will get five responses, one of which is from 1995 so I didn't list it
above (you can weed that out if you click on "LIMITS" and enter the
years you want under publication date).  To get to the full-text,
click on the word "PubLink" and you will see them.

Does this answer your question?  If you'd like the link to the
non-full-text articles as well I'd be happy to supply that.  Otherwise
I'll put these results and my search strategy in as an answer with
your permission.

librariankt

Hi Shotie48,

I have found a number of articles in PubMed MEDLINE that I think you
will find useful for your research.  I am putting the citation
information and the direct link into the PubMed MEDLINE abstract
information for each article.

This was my search statement in PubMedMEDLINE:
(((((((((((((((((((((("Purpura, Thrombocytopenic,
Idiopathic/complications"[MESH] OR "Purpura, Thrombocytopenic,
Idiopathic/congenital"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/diagnosis"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/diet therapy"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/drug therapy"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/epidemiology"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/etiology"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/genetics"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/microbiology"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/mortality"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/nursing"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/pathology"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/physiopathology"[MESH]) OR "Purpura, Thrombocytopenic,
Idiopathic/prevention and control"[MESH]) OR "Purpura,
Thrombocytopenic, Idiopathic/radiotherapy"[MESH]) OR "Purpura,
Thrombocytopenic, Idiopathic/surgery"[MESH]) OR "Purpura,
Thrombocytopenic, Idiopathic/therapy"[MESH]) OR "Purpura,
Thrombocytopenic, Idiopathic/ultrasonography"[MESH]) AND Review[ptyp])
AND English[Lang]) AND (("infant"[MeSH Terms] OR "child"[MeSH Terms])
OR "adolescent"[MeSH Terms])) AND (("human"[MeSH Terms] OR
"hominidae"[MeSH Terms]) OR "Human"[MeSH Terms])) AND ("1997"[PDat] :
"2003"[PDat]))

I searched for the MeSH term "Purpura, Thrombocytopenic, Idiopathic"
according to certain subheadings.  I limited it to pediatric cases in
humans, written in English from 1997 to 2003 (approx. 5 years).  In
addition, I limited the results to review articles.  These are
peer-reviewed articles that usually have a broader scope than
individual clinical trials.  This search returned 55 articles.  I'm
giving you 45 of the 55, because some of them appear to be less
relevant than others - but I'm happy to get you more if you need them!

1:  Jubelirer SJ, Harpold R.  The role of the bone marrow examination
in the diagnosis of immune thrombocytopenic purpura: case series and
literature review. Clin Appl Thromb Hemost. 2002 Jan;8(1):73-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11991243&dopt=Abstract

2:  Adams JR, Nathan DP, Bennett CL.  Pharmacoeconomics of therapy for
ITP: steroids, i.v.Ig, anti-D, and splenectomy. Blood Rev. 2002
Mar;16(1):65-7.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11913999&dopt=Abstract

3:  Nugent DJ.  Childhood immune thrombocytopenic purpura. Blood Rev.
2002 Mar;16(1):27-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11913990&dopt=Abstract

4:  Blanchette V.  Childhood chronic immune thrombocytopenic purpura
(ITP). Blood Rev. 2002 Mar;16(1):23-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11913989&dopt=Abstract

5:  Tarantino MD.  Acute immune (idiopathic) thrombocytopenic purpura
in childhood. Blood Rev. 2002 Mar;16(1):19-21.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11913988&dopt=Abstract

6:  Gadner H. Management of immune thrombocytopenic purpura in
children. Rev Clin Exp Hematol. 2001 Sep;5(3):201-21; discussion
311-2.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11703815&dopt=Abstract

7:  Sandler SG.  Intravenous Rh immune globulin for treating immune
thrombocytopenic purpura. Curr Opin Hematol. 2001 Nov;8(6):417-20.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11604585&dopt=Abstract

8:  Buchanan GR.  Idiopathic thrombocytopenic purpura in childhood.
Pediatr Ann. 2001 Sep;30(9):527-33. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11554261&dopt=Abstract

9:  Leung AK, Chan KW. Evaluating the child with purpura. Am Fam
Physician. 2001 Aug 1;64(3):419-28.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11515831&dopt=Abstract

10:  Kaplan C.  Immune thrombocytopenia in the foetus and the newborn:
diagnosis and therapy. Transfus Clin Biol. 2001 Jun;8(3):311-4.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11499984&dopt=Abstract

11:  Buchanan GR, Adix L.  Outcome measures and treatment endpoints
other than platelet count in childhood idiopathic thrombocytopenic
purpura. Semin Thromb Hemost. 2001 Jun;27(3):277-85.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11446661&dopt=Abstract

12:  Bolton-Maggs PH, Dickerhoff R, Vora AJ.  The nontreatment of
childhood ITP (or "the art of medicine consists of amusing the patient
until nature cures the disease"). Semin Thromb Hemost. 2001
Jun;27(3):269-75.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11446660&dopt=Abstract

13:  Burrows RF.  Platelet disorders in pregnancy. Curr Opin Obstet
Gynecol. 2001 Apr;13(2):115-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11315863&dopt=Abstract

14:  Lilleyman JS.  Chronic childhood idiopathic thrombocytopenic
purpura. Baillieres Best Pract Res Clin Haematol. 2000
Sep;13(3):469-83.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11030046&dopt=Abstract

15:  Bolton-Maggs PH.  Idiopathic thrombocytopenic purpura. Arch Dis
Child. 2000 Sep;83(3):220-2.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10952638&dopt=Abstract

16:  Blanchette V, Carcao M.  Approach to the investigation and
management of immune thrombocytopenic purpura in children. Semin
Hematol. 2000 Jul;37(3):299-314.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10942224&dopt=Abstract

17:  George JN, Kojouri K, Perdue JJ, Vesely SK.  Management of
patients with chronic, refractory idiopathic thrombocytopenic purpura.
Semin Hematol. 2000 Jul;37(3):290-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10942223&dopt=Abstract

18:  Gill KK, Kelton JG.  Management of idiopathic thrombocytopenic
purpura in pregnancy. Semin Hematol. 2000 Jul;37(3):275-89.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10942222&dopt=Abstract

19:  Aster RH.  Can drugs cause autoimmune thrombocytopenic purpura?
Semin Hematol. 2000 Jul;37(3):229-38
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10942217&dopt=Abstract

20:  Lin WC, Hsiao CC, Eng HL.  Idiopathic thrombocytopenic purpura
preceding malignant lymphoma: report of one case. Acta Paediatr
Taiwan. 1999 Jan-Feb;40(1):39-42.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10910585&dopt=Abstract

21:  Boyne MS, Dye KR.  Crohn's colitis and idiopathic
thrombocytopenic purpura. Postgrad Med J. 2000 May;76(895):299-300.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10775285&dopt=Abstract

22:  Choudhry VP, Kashyap R, Pati HP.  Management of idiopathic
thrombocytopenic purpura. Indian J Pediatr. 1998 May-Jun;65(3):401-7.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10771991&dopt=Abstract

23:  De Mattia D, Del Principe D, Del Vecchio GC, Jankovic M,
Arrighini A, Giordano P, Menichelli A, Mori P, Zecca M, Pession A. 
Acute childhood idiopathic thrombocytopenic purpura: AIEOP consensus
guidelines for diagnosis and treatment.Associazione Italiana di
Ematologia e Oncologia
Pediatrica. Haematologica. 2000 Apr;85(4):420-4. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10756369&dopt=Abstract

24:  Tarantino MD.  Treatment options for chronic immune (idiopathic)
thrombocytopenia purpura in
children. Semin Hematol. 2000 Jan;37(1 Suppl 1):35-41. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10676923&dopt=Abstract

25:  Medeiros D, Buchanan GR.  Idiopathic thrombocytopenic purpura:
beyond consensus. Curr Opin Pediatr. 2000 Feb;12(1):4-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10676767&dopt=Abstract

26:  Ware RE.  Autoimmune hemolytic and thrombocytopenic disease in
the adolescent patient. Adolesc Med. 1999 Oct;10(3):377-84.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10611935&dopt=Abstract

27:  Clark AL.  Clinical uses of intravenous immunoglobulin in
pregnancy. Clin Obstet Gynecol. 1999 Jun;42(2):368-80.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10370855&dopt=Abstract

28:  Kuhne T, Imbach P.  Management of children with acute and chronic
immune thrombocytopenic purpura. Transfus Sci. 1998 Sep;19(3):261-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10351138&dopt=Abstract

29:  Rand ML, Wright JF.  Virus-associated idiopathic thrombocytopenic
purpura. Transfus Sci. 1998 Sep;19(3):253-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10351137&dopt=Abstract

30:  Sutor AH, Gaedicke G.  Acute autoimmune thrombocytopenia.
Baillieres Clin Haematol. 1998 Jun;11(2):381-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10097815&dopt=Abstract

31:  Kuhne T, Imbach P.  Chronic immune thrombocytopenic purpura in
childhood. Semin Thromb Hemost. 1998;24(6):549-53.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10066150&dopt=Abstract

32:  Sutor AH.  Acute immune thrombocytopenia in childhood. Are we
treating the platelet count? Semin Thromb Hemost. 1998;24(6):545-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10066149&dopt=Abstract

33:  Rescorla FJ.  Laparoscopic splenectomy. Semin Pediatr Surg. 1998
Nov;7(4):207-12.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9840900&dopt=Abstract

34:  Lichtin A.  Idiopathic thrombocytopenic purpura: guidance amid
uncertainty. Cleve Clin J Med. 1998 Nov-Dec;65(10):510-4.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9830783&dopt=Abstract

35:  Kuhne T, Elinder G, Blanchette VS, Garvey B.  Current management
issues of childhood and adult immune thrombocytopenic purpura (ITP).
Acta Paediatr Suppl. 1998 Jun;424:75-81.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9736225&dopt=Abstract

36:  Winiarski J.  Mechanisms in childhood idiopathic thrombocytopenic
purpura (ITP). Acta Paediatr Suppl. 1998 Jun;424:54-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9736220&dopt=Abstract

37:  Wadenvik H, Stockelberg D, Hou M.  Platelet proteins as
autoantibody targets in idiopathic thrombocytopenic purpura. Acta
Paediatr Suppl. 1998 Jun;424:26-36.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9736215&dopt=Abstract

38:  Imbach P, Kuhne T.  Immune thrombocytopenic purpura ITP. Vox
Sang. 1998;74 Suppl 2:309-14.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9704461&dopt=Abstract

39:  Scaradavou A, Bussel JB.  Clinical experience with anti-D in the
treatment of idiopathic thrombocytopenic purpura. Semin Hematol. 1998
Jan;35(1 Suppl 1):52-7.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9523749&dopt=Abstract

40:  Blanchette V, Freedman J, Garvey B.  Management of chronic immune
thrombocytopenic purpura in children and adults. Semin Hematol. 1998
Jan;35(1 Suppl 1):36-51.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9523748&dopt=Abstract

41:  Tarantino MD, Goldsmith G.  Treatment of acute immune
thrombocytopenic purpura. Semin Hematol. 1998 Jan;35(1 Suppl 1):28-35.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9523747&dopt=Abstract

42:  George JN, Raskob GE.  Idiopathic thrombocytopenic purpura: A
concise summary of the pathophysiology and diagnosis in children and
adults. Semin Hematol. 1998 Jan;35(1 Suppl 1):5-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9523743&dopt=Abstract

43:  Zlatanic J, Korelitz BI, Wisch N, Kim P, Ammirati M, Schwarz S,
Gruenstein S, Lipsey L.  Inflammatory bowel disease and immune
thrombocytopenic purpura: is there a correlation? Am J Gastroenterol.
1997 Dec;92(12):2285-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9399771&dopt=Abstract

44:  Wang ZY, Shen ZX.  Megakaryocytes and platelets in immune
thrombocytopenic purpura. Baillieres Clin Haematol. 1997
Feb;10(1):89-107.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9154317&dopt=Abstract

45:  Imbach PA, Kuhne T, Hollander G. Immunologic aspects in the
pathogenesis and treatment of immune thrombocytopenic purpura in
children. Curr Opin Pediatr. 1997 Feb;9(1):35-40.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9088753&dopt=Abstract


Good luck!

librariankt

Hello shotie, 

A Medline search on idiopathic thrombocytopenia purpura, limited to
human subjects aged 0-18 years, gave only one reference to a clinical
trial which is relevant to the time frame you specify as well as
referring to pediatric patients.

Ugeskr Laeger 1998 Mar 9;160(11):1640-4 
[Randomized comparison of intravenous immunoglobulin and
methylprednisolone pulse therapy in children with newly diagnosed
idiopathic thrombocytic purpura. The Danish ITP Study Group]
[Article in Danish]
Rosthoj S, Nielsen SM, Pedersen FK.
Abstract at  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9522658&dopt=Abstract

Apart from this, only two earlier studies were retrieved, but both
were about the management of maternal thrombocytic purpura in
pregnancy.

I'm placing this as a comment, since it does not answer your query
fully.