Hello freddiep,
Firstly, I would like to reinforce the disclaimer at the bottom of the
page, that Google Answers is not intended as a substitute for
professional medical advice, and any information you receive here
should be regarded as background information for discussion with your
own physician.
Having said that, the general recommendation is that Adipex and Prozac
should not be used together.
In order to obtain this information, I used the drug interactions
checker at Drugs.com http://www.drugs.com The link to the checker is
on one of the tabs above the search box at the top of the page. I
entered Adipex and Prozac into the list, and then requested any
interactions between them to be displayed.
The results obtained refer to the generic names for these drugs and
the class of drug activity. The generic name for Prozac is fluoxetine,
and the generic name for Adipex is phentermine. Adipex is a
sympathomimetic appetite suppressant, while Prozac is a selective
serotonin reuptake inhibitor.
The drug interactions checker came up with the recommendation that
taking these two drugs together is something that should generally be
avoided, and that people who are given both need to be monitored very
carefully by their physician.
“Several case reports suggest that patients treated with serotonin
reuptake inhibitors (SRIs) may exhibit an increased sensitivity to
sympathomimetic agents. The mechanism of interaction is unclear. The
reaction has been reported when fluoxetine was used concomitantly with
phentermine, amphetamine, or phenylpropanolamine.”
This is saying that taking Prozac will make you more sensitive to the
effects of Adipex. Therefore, you are more likely to experience the
symptoms of overdose, even at normal doses of Adipex. I went into the
main search facility at Drugs.com and searched on Adipex, obtaining
the following information page
http://www.drugs.com/xq/cfm/pageid_0/htm_202069/tgid_36/type_cons/bn_Adipex%2DP/micr_medex/qx/index.htm
The listing of overdose symptoms is as follows:
“Abdominal or stomach cramps; coma; confusion; convulsions (seizures);
diarrhea (severe); dizziness, lightheadedness, or fainting; fast
breathing; feeling of panic; fever; hallucinations (seeing, hearing or
feeling things that are not there); high or low blood pressure;
hostility with urge to attack; irregular heartbeat; nausea or vomiting
(severe); overactive reflexes; restlessness; trembling or shaking;
tiredness, weakness, and mental depression following effects of
excitement”
Also included in the information was a warning that this combination
of drugs can seriously affect the heart:
Under a discussion of the use of other drugs with Adipex or similar
products:
“Selective serotonin reuptake inhibitors (citalopram [e.g., Celexa],
fluoxetine [e.g., Prozac], fluvoxamine [e.g., Luvox], paroxetine
[e.g., Paxil], sertraline [e.g., Zoloft]) - It is not known whether
using two different appetite suppressants together or using a
sympathomimetic appetite suppressant with a selective serotonin
reuptake inhibitor is safe and effective. There have been some serious
unwanted effects on the hearts of people who used two different
appetite suppressants together.”
I also did a quick Medline search on the names of the two drugs. I
found a reference to the following article:
Bostwick JM, Brown TM.
A toxic reaction from combining fluoxetine and phentermine.
Journal of Clinical Psychopharmacology, 1996, Volume 16, 189-190.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8690835&dopt=Abstract
Unfortunately no summary of the article is provided. However, the
title itself reinforces the warning given above.
Search strategy on Google: drug interaction database |
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