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Q: Neural stem cells ( Answered 5 out of 5 stars,   2 Comments )
Question  
Subject: Neural stem cells
Category: Science
Asked by: jleibler-ga
List Price: $10.00
Posted: 28 Apr 2003 19:53 PDT
Expires: 28 May 2003 19:53 PDT
Question ID: 196851
Is there a diagram illustrating the differentiation and migration of
neural stem cells or the assymetric division and migration of neural
stem cells - preferably in a mammalian embryo or alternatively in a
mammalian adult brain?
Answer  
Subject: Re: Neural stem cells
Answered By: andrewxmp-ga on 29 Apr 2003 09:36 PDT
Rated:5 out of 5 stars
 
Hi jleibler!

I have been studying this particular mechanism myself and have even
better than a diagram of this process: a movie.  This is a videotaped
lecture with very good diagrams from my neuroscience class at JHU:
[ http://mfile.akamai.com/7111/mov/www.mb.jhu.edu/media/ghosh.h.mov ]
The entire movie is about neural development and differentiation,
however some specific sections are most applicable to your question. 
Specifically, look at the times from about 9 minutes to about 15
minutes into the video (or, if you don't have a time counter on your
video player, the section about 1/3 through the entire video).  This
is a large video file, so please give it time to buffer correctly, and
it should run smoothly.

You will need Quicktime to watch this video.  You can download
Quicktime here:
[ http://www.apple.com/quicktime/products/qt/ ]

It is fairly detailed, and also describes the process by which this
mechanism of differentiation is controlled.

In addition to the above video, I found a simple diagram of this
process at:
[ http://www.elis.sk/bll/00/full/bll0800h.pdf ]

If you don't have it, you will need to dowload the free Adobe Acrobat
Reader in order to view this .pdf file.  You can get the free Adobe
Acrobat Reader from:
[ http://www.adobe.com/products/acrobat/readstep2.html ]

Yes, the bulk of this document is in some non-English language,
however the diagram and it's caption are in English.

Another good diagram of this process can be found at:
[ http://www.cellbio.wustl.edu/faculty/huettner/Temple01.pdf ]
on page 2.

The previously-mentioned video, however, is by far the best
diagram/explanation of this process that I've found.  I hope these
resources satisfy your needs; please let me know if there are any
clarifications necessary or other questions.

Sincerely,
Andrewxmp
jleibler-ga rated this answer:5 out of 5 stars

Comments  
Subject: Re: Neural stem cells
From: robertskelton-ga on 29 Apr 2003 01:30 PDT
 
I'm pretty stupid when it comes to biology, but perhaps these are what
you are after:

http://www.riken.go.jp/engn/r-world/research/lab/cdb/asy/
http://www.idac.tohoku.ac.jp/about2002/org/NeurochemistryMB.html
Subject: Re: Neural stem cells
From: jleibler-ga on 29 Apr 2003 01:43 PDT
 
That is close to what I am looking for but not quite right as it is
from drosophila and I am looking for an example from mammals. 
Migration is also a key word I would like represented in the diagram.
Neural stem cell differentiation and migration occurs during
embryogenesis and in adulthood. I am looking for something that
represents the migration during embryogenesis

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