It’s me again, Tom! :)
1. Robert Gordon University, Scotland
“The Buccal drug delivery system developed and patented by the Robert
Gordon University provides the ability for a combination approach to
drug delivery providing both a peak initial dosage as well as slow
release mechanism. This is achieved using a bilayer tablet, which
adheres to the buccal mucosa using a bioadhesive polymer and has an
outer rapid release layer and an inner controlled release layer. The
combination therapy is particularly suited to applications such as
Nicotine Replacement Therapy.”
http://www.rgu.com/research/innovation/page.cfm?pge=570
2. Generex
“Generex's mission is to develop innovative technologies for reliable,
convenient, pain-free delivery of large-molecule drugs. To date we've
focused on creating a unique liquid formulation that can be
administered directly into the mouth as an aerosol spray for
absorption through the buccal mucosa, the mucous membranes that line
the inner walls of the cheek.”
http://www.generex.com/ (enter site through Flash or non-Flash
option, select Platform Technology, select Buccal delivery
3. Controlled Therapeutics, Scotland
“The Hydrogel as a Buccal Delivery System
CT are developing their controlled release polymer as a means to
deliver drugs across the buccal or gingival mucosa. Equally the system
can be used to deliver drugs locally to the mouth…. The hydrogel
polymer system is particularly well-suited to buccal delivery because
of its natural muco-adhesive properties. The swelling and softening of
the polymer make it an effective and comfortable vehicle for
oromucosal delivery…. The hydrogel has been approved in the EU and the
US for delivery of an active pharmaceutical to the vaginal mucosa…. A
patent has been filed for the application of the hydrogel as a buccal
delivery system. Therapeutic areas that are being actively studied
are: Xerostomia, Oral mucositis Other areas that the company
considers to be of potential interest are: Migraine, Nicotine
withdrawal, Epilepsy, Drug Addiction, Small peptides”
http://www.ctscotland.com/bds.html
4. PCT Inc.
“New PCT Buccal Delivery Tablet - A thin tablet system (e.g., 0.8-2
mm.) has been developed which is held in place by a mucoadhesive
through which the drug does not permeate. The drug-containing layer of
the tablet erodes or permits diffusion to release the drug. The thin
tablet can contain multiple layers, if needed, and many properties can
be tailored….Release rate can be controlled by adjusting the rate of
erosion of (or diffusion from) the drug-releasing layer through
variations in the layer composition. Combined with the use of 2 or 3
layers, this permits tailoring of the blood levels…. Adhesiveness is
tightly controlled over a wide range. Attachment has been made strong
enough to approach tearing the skin upon removal; it has also been
made very light. In some formulations for shorter release time, the
base can be made soluble so there is no base membrane to remove or
swallow.”
http://www.pctincusa.com/pharm_buccal.htm
5. Columbia Laboratories Inc
“The Bioadhesive Delivery System consists principally of a polymer,
polycarbophil, and an active ingredient. The Bioadhesive Delivery
System is based upon the principle of bioadhesion, a process by which
the polymer adheres to epithelial surfaces and to mucin, a naturally
occurring secretion of the mucous membranes. The polymer remains
attached to epithelial surfaces and/or the mucin and is discharged
upon normal cell turnover or upon the detachment of the mucin from the
mucous membranes, a physiological process which, depending upon the
area of the body, occurs every 12 to 72 hours. This extended period of
attachment permits the Bioadhesive Delivery System to be utilized in
products when extended duration of effectiveness is desirable or
required.”
http://www.columbialabs.com/tech.htm
6. DelRx
“The Company’s principal product development programs are based
delivering drugs by spray into the mouth, although pulmonary
formulations are also being developed. Based on a Pressurized Metered
Dose Applicator™ (pMDA™) Oral Spray Drug Delivery System, DelRx uses
proprietary technologies to create aerosols from solid or liquid drug
formulations for delivery systemically via the lining of the mouth and
upper throat (the buccal cavity)…. DelRx’ first product in development
is a buccally absorbed insulin and has just completed a successful
pilot Phase II clinical trial in Type I diabetics…. The next two new
products in the pipeline are now planned to be oral spray formulations
of calcitonin for osteoporosis and fentanyl for breakthrough cancer
pain.”
http://www.delrx.com/profile.html
7. Baxter BioScience and Epic Therapeutics
“Epic Therapeutics and Baxter's BioScience business recently initiated
a research collaboration to explore the feasibility of applying Epic's
technology, called ProMaxx™ Microsphere Technology, to novel ways of
delivering proteins by such routes as intravenous release, inhalation
and buccal delivery.”
http://www.baxter.com/utilities/news/releases/2002/03-14-02growthconf.html
“Epic Therapeutics, Inc. has developed a proprietary, protein-matrix
drug delivery technology, ProMaxx®, that is produced entirely in water
and is substantially more versatile and cost-effective at solving
today's pharmaceutical and biotech drug delivery problems than current
technologies. This platform technology produces bioerodible protein
microspheres to deliver both small and macromolecular drugs and can
tailor both microsphere size and drug release characteristics for the
desired therapeutic application. The microspheres are applicable to
immediate and sustained release delivery and can be administered by
the injectable, pulmonary, nasal, topical and ophthalmic routes.”
http://www.epictherapeutics.com/
Epic is now part of the Baxter group.
8. Cardinal Health
“The Zydis® fast-dissolving dosage form dissolves instantly on the
tongue and does not require water to aid swallowing. The outstanding
convenience and acceptability of Zydis makes it an ideal dose form for
patients who find it difficult, unpleasant or inconvenient to swallow
conventional solid dose forms.”
http://www.cardinal.com/pts/content/manufacture/comman/ir/zydis.asp
9. NovaDel Pharma (formerly Flemington Pharmaceutical)
“NovaDel [OTC BB; NVDL] uses their patented novel drug delivery system
for both prescription and over the counter drugs. Its
Immediate-Immediate Release(tm) technology, which implements a lingual
spray to rapidly deliver drugs through the oral mucosal membrane and
into the systemic blood system, can be applied to a variety of drugs
in numerous therapeutic areas.”
http://www.novadel.com/ (web site currently under construction)
10. ChitoGenics
“The biopolymer, N,O-Carboxymethylchitosan ( NOCC )… is strongly
adherent to soft tissues… As an example of in-house R&D, buccal
delivery devices based on hydrophilic polymers incorporated into
different elastomers have been formulated.The devices which were
disc-shaped and weighed 50-60mg adhered for up to 24 hours in vivo and
were reported to be comfortable. The drugs, melatonin and
chlorpheniramine maleate, were easily incorporated into the buccal
devices using dry powder mixing techniques.”
http://www.chitogenics.ns.ca/applicat.htm
11. Atrix
“This unique polymer-based system is designed to deliver drugs across
oral mucosal tissues.
The BEMA™ film is a small, semi-soft disc that adheres to the mucosa,
such as the side of the mouth, and delivers the drug as the film
bioerodes. There is no need to remove the film because it dissolves
with the moisture from the mucosa…. June 2002 Atrix announces IND
submission to test BEMA delivery of migraine product in humans”
http://www.atrixlabs.com/ourtech/bema.cfm
Collaboration with Pfizer
“
http://www.atrixlabs.com/pressr/2000/081000.cfm
12. Cephalon
http://www.cephalon.com/
Cephalon developed Actiq
“ACTIQ is a solid drug matrix containing the opioid analgesic
fentanyl. The ACTIQ unit consists of the medicated sucrose matrix
attached to a handle…. During the recommended dosing period of 15
minutes, 25% of the total dose is absorbed rapidly through the oral
mucosa into the bloodstream (no first-pass metabolism). The remainder
of the total dose (75%) is swallowed and slowly absorbed through the
gastrointestinal tract…. The unique oral transmucosal system (OTS™) of
ACTIQ allows fentanyl to rapidly dissolve into the highly permeable
and well-vascularized oral mucosa.”
http://www.actiq.com/physicians/aboutbtcp/whatisactiq.asp
13. Corium International
“CORPLEX™ is the foundation for customized dosage forms
Film Forming Liquid: Offers rapid onset Stays on to continuously
deliver drug Film can be degradable or peelable Can be applied to
mucosa or skin
Rapidly Dissolving Film: Film sticks to oral mucosa & dissolves
rapidly (1 - 2 sec) Film does not stick to fingers Induces rapid onset
Can be designed to dissolve at various rates (secs/mins/hrs)
Solid State Film: Adhesive layer dissolves Backing protects from
spreading Offers continuous drug release Can be designed to adhere to
skin or as mucosal patch
http://www.corium.md/tech_dermal.html
“Corium's delivery platforms are based on the company's proprietary
CORPLEX™ hydrogel technology. This new polymer technology, is a
versatile medical polymer system that can be applied to many drug
delivery and medical product applications. The versatility of CORPLEX™
is that it encompasses the blending of polymers that are mixed in a
fashion unlike most pharmaceutical products. It has undergone several
years of basic research to fully understand its uniqueness around
bioadhesive, water absorption, physical and chemical properties.”
http://www.corium.md/technology.html
14. Noven
“In part to aid dentists and their patients, and in part to pioneer a
new class of drug delivery, Noven developed the Dentipatch lidocaine
delivery system - the first transmucosal patch ever approved. For
dentists and their patients, this means that there is an alternative
to the pain of needle injections, dental scaling, root planings and
other procedures. For your company, this means that there is a new,
adaptable transmucosal delivery system that can distiguish your
bio-engineered molecule or other compound in the marketplace.”
15. Shire Laboratories
“Rapitrol™ - Rapid Onset: Rapitrol consists of two drug delivery
approaches that are designed to be rapidly absorbed. Rapitrol can be
designed to deliver compounds: * orally -- Rapitrol™ RO, or
* transmucosally -- Rapitrol™ RT (e.g., sublingual, buccal, etc.)
The added feature of transmucosal delivery is that compounds can be
absorbed directly into the bloodstream.”
http://www.shirelabs.com/techguide/rapitrol.html
16. CIMA Laboratories
“We are also developing new drug delivery technologies, including
sustained release versions of our fast dissolve technologies, and
OraVescent®, an enhanced absorption transmucosal drug delivery
technology.”
http://www.cimalabs.com/company.htm
And one about which I’m not sure whether it is relevant to you or not:
17. Abonetics Ltd
From a news source“Abonetics was founded in 1996 based on the world
class technology developed at the Interdisciplinary Research Centre
(IRC) in Biomedical Materials at Queen Mary and Westfield College,
London… Abonetics is currently a 'virtual' company, as it has no
separately owned facilities at this stage, it has the rights to all
intellectual property developed by the IRC.. . Dental Applications:
This field of research focuses on… drug release systems for
transmucosal delivery… A drug delivery device, aimed at a significant
market sector, entered first stage human clinical trials in 1998.”
http://212.67.202.140/~biotech/News/London/abonetics_ltd.htm
From the IRC site: “examining the ability of experimental polymer
mixtures to release macromolecules both for local and systemic
delivery within the oral cavity. The controlled release of the active
agents is a function of the composition of the polymer mixtures and
the surface characteristics of the polymer construct.”
http://www.irc-biomed-materials.qmw.ac.uk/Pages/Research/DentalBiomaterials/Research-Dental.htm
Phew, this was a toughie! I hope these references are what you were
wanting.
Search strategy:
1. “buccal delivery” “buccal drug delivery”
2. “oromucosal delivery” “oromucosal drug delivery”
3. transbuccal
4. “transmucosal delivery” “transmucosal drug delivery”
5. “oral spray” “drug delivery” |
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