I need some sythesis pathways for Vanillin. It is a food flavoring
additive. Reagents and conditions are the most important areas at the
moment. The CAS number is 148-53-8 and 121-33-5 for the ortho and para
isomers respectivley

Hello -

In addition to the two references listed below, I have found the
following syntheses:

from 4-hydroxybenzaldehyde (with reagents, weights, the whole deal):
http://valhalla.chem.udel.edu/vanillin.html




And a bio-synthetic route as well (should be free full-text):
http://aem.asm.org/cgi/content/full/66/2/684

A patented bio-synthetic route:
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=/netahtml/search-adv.htm&r=1&f=G&l=50&d=PALL&p=1&S1=6,372,461.WKU.&OS=PN/6,372,461&RS=PN/6,372,461

A company listing their process (though no reagents are given):
http://www.rhodia-perfumeryspecialties.com/pdf/Rhovanil.pdf



Please let me know if you have further questions.

synarchy


Search strategy:
"synthesis of vanillin"
vanillin synthesis

Isoeugenol to vanillin:
http://www.rhodium.ws/chemistry/piperonal.isosafrole.html

4-hydroxybenzaldehyde to vanillin:
http://216.239.39.100/search?sourceid=navclient&q=cache:http%3A%2F%2Fvalhalla.chem.udel.edu%2Fvanillin.html

Lots of references: http://www.inchem.org/documents/sids/sids/sids5b06.htm