Google Answers: Effects of Trans Fatty Acids(TFAs) on CYP-448 & 450 iso-enzyme system

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Q: Effects of Trans Fatty Acids(TFAs) on CYP-448 & 450 iso-enzyme system ( No Answer, 0 Comments )

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Subject: Effects of Trans Fatty Acids(TFAs) on CYP-448 & 450 iso-enzyme system
Category: Health > Conditions and Diseases
Asked by: ngang-ga
List Price: $15.00

Posted: 28 May 2003 07:52 PDT
Expires: 27 Jun 2003 07:52 PDT
Question ID: 209781

The CYP 1A1 & 1A2 iso-enzymes mediate the sysnthesis  of the
onco-protective 2-(OH) estrone & estradiol (and their methoxy
metabolites). The CYP 3A4 & 1B1 mediate the synthesis of the
onco-toxic 16-(OH) estrone & estradiol (and their methoxy
metabolites). I need some studies proving that TFAs down-regulate CYP
1A1 & 1A2, and up-regulate CYP 3A4 & 1B1.

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