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Subject:
Source of Drug used in Cancer Therapy
Category: Health > Medicine Asked by: solars-ga List Price: $15.00 |
Posted:
04 Jun 2003 15:45 PDT
Expires: 04 Jul 2003 15:45 PDT Question ID: 213142 |
I need to locate a company which currently can provide a compound called "zwitterionic piperazine" for use in cancer therapy. Ideally I would like email contact details, and they must be a current source, not a past source of supply |
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Subject:
Re: Source of Drug used in Cancer Therapy
Answered By: synarchy-ga on 04 Jun 2003 18:00 PDT |
Hello - "Zwitterionic" means that a compound has multiple charged moeities, but a net neutral charge. Amino acids, some phospholipids, some detergents, and some buffer compounds fit into this category. Zwitterionic piperazine derivatives also have a multiple ionizable groups, but at physiological pH, have a net neutral charge. One of these compounds, 4-(2 Hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES) is a common buffer solution, has been reviewed in cancer: http://www.integratedbiologics.com/Research%20articles/clinical_study.htm and it is available from: Sigma: http://www.sigmaaldrich.com/cgi-bin/hsrun/Distributed/HahtShop/HAHTpage/frmCatalogSearchPost?Brand=FLUKA&ProdNo=54457 42 other suppliers: http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=1929 enrofloxacin is also a zwitterionic piperazine derivative (along with being a fluoroquinolone antibiotic): http://www.poultry.baytril.com/index.cfm/page/27/title/Chemistry.htm Available from: http://www.riausa.com/pricelist.htm Let me know if there are other particular zwitterionic piperazines that you are interested in. synarchy Search strategy: piperazine zwitterionic hepes |
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