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Q: enlarged prostate ( Answered,   0 Comments )
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Subject: enlarged prostate
Category: Miscellaneous
Asked by: stevetwo-ga
List Price: $50.00
Posted: 04 Jul 2003 15:48 PDT
Expires: 03 Aug 2003 15:48 PDT
Question ID: 225221
does an enlarged prostate of 50 grams signal cancer
Answer  
Subject: Re: enlarged prostate
Answered By: bobbie7-ga on 04 Jul 2003 19:08 PDT
 
Hello Stevetwo-ga,  
 

The information provided here is for informational purposes and should
not be used as a substitute for a consultation with your physician or
other health care provider. A licensed physician should be consulted
for diagnosis and treatment of any and all medical conditions.



Enlargement of the Prostate is also termed benign prostatic
hyperplasia, or BPH or Prostatic Hyperplasia

“Nodular prostatic hyperplasia (also termed benign prostatic
hyperplasia, or BPH) is a common condition as men age. The normal
prostate weighs 20 to 30 grams, but prostates with nodular hyperplasia
can weigh from 50 to 100 grams. This enlargement of the prostate
presses upon the urethra, leading to difficulty in urination,
hesitancy, dribbling, and frequent urination at night. This urinary
tract obstruction may lead to urinary retention and an increased risk
for infection (prostatitis).”

The Buffalo Niagara Prostate Cancer Consortium
http://www.bnpcc.org/files/1_2_1/pdf/prostate_pathology.pdf


=======================================


According to the publication titled “What I need to know about
Prostate Problems” by The NATIONAL INSTITUTES OF HEALTH and the
National Kidney and Urologic Diseases Information Clearinghouse,
prostate enlargement or BPH is not a sign of cancer.

What is prostate enlargement, or BPH?

“If you’re a man over 50 and have started having problems urinating,
the reason could be an enlarged prostate, or BPH. As men get older,
their prostate keeps growing. As it grows, it squeezes the urethra.
Since urine travels from the bladder through the urethra, the pressure
from the enlarged prostate may affect bladder control.”

If you have BPH, you may have one or more of these problems:

- A frequent and urgent need to urinate. You may get up several times
a night to go to the bathroom.

- Trouble starting a urine stream. Even though you feel you have to
rush to get to the bathroom, you find it hard to start urinating.

- A weak stream of urine.

- A small amount of urine each time you go.

-  The feeling that you still have to go, even when you have just
finished urinating.

- Leaking or dribbling.

- Small amounts of blood in your urine.


Is BPH a sign of cancer?

“No. It’s true that some men with prostate cancer also have BPH, but
that doesn’t mean that the two conditions are always linked. Most men
with BPH don’t develop prostate cancer. However, because the early
symptoms are the same for both conditions, you should see a doctor to
evaluate these symptoms.”

The NATIONAL INSTITUTES OF HEALTH and the National Kidney and Urologic
Diseases Information Clearinghouse
http://www.niddk.nih.gov/health/urolog/pubs/prospro/ProstateProb.pdf


=======================================


According the National Cancer Institute there is no evidence that
enlargement of the prostate can cause cancer.

“As men age, both benign prostate conditions and prostate cancer
become more frequent. The most common benign prostate conditions are
prostatitis (inflammation of the prostate) and benign prostatic
hyperplasia (BPH) (enlargement of the prostate). There is no evidence
that prostatitis or BPH cause cancer, but it is possible for a man to
have one or both of these conditions and to develop prostate cancer as
well.”

Source: National Cancer Institute 
http://cis.nci.nih.gov/fact/5_29.htm


=======================================


According to the Internet Pathology Laboratory for Medical Education
an enlarged prostate is NOT a precursor to cancer.

“The normal prostate weighs 20 to 30 gm, but most prostates with
nodular hyperplasia can weigh from 50 to 100 gm. Nodular hyperplasia
is NOT a precursor to carcinoma.”
The Internet Pathology Laboratory for Medical Education
http://medlib.med.utah.edu/WebPath/TUTORIAL/PROSTATE/PROSTATE.html


=======================================


According to Prostate Cancer UK, Nodular hyperplasia is NOT a
precursor to carcinoma.
“Nodular prostatic hyperplasia (also termed benign prostatic
hyperplasia, or BPH) is a common condition as men age. Perhaps a
fourth of men have some degree of hyperplasia by the fifth decade of
life. By the eighth decade, over 90% of males will have prostatic
hyperplasia. However, in only a minority of cases (about 10%) will
this hyperplasia be symptomatic and severe enough to require surgical
or medical therapy.”

(..)

“The normal prostate weighs 20 to 30 gm, but most prostates with
nodular hyperplasia can weigh from 50 to 100 gm.

(..)

“Nodular hyperplasia is NOT a precursor to carcinoma.”

Prostate Cancer UK
http://www.prostatecanceruk.org/pathology-1.html



==================================


Frequently asked questions related to prostate cancer.


Is prostate enlargement the same as prostate cancer? 

“No. As a man ages, the prostate can increase in size many times
without becoming cancerous. The medical term for noncancerous prostate
enlargement is benign prostatic hyperplasia, or BPH.”

“Prostate enlargement is not the same as prostate cancer, and BPH
cannot "turn into" prostate cancer. However, BPH and prostate cancer
can exist together. Even if cancer is not present, an enlarged
prostate may cause other problems, such as interfering with a man's
ability to urinate. “

Source: Your Medical Source
http://www.yourmedicalsource.com/library/prostatecancer/PCA_whatis.html

http://health.yahoo.com/health/centers/prostate_cancer/1.html

http://www.yourmedicalsource.com/library/prostatecancer/PCA_faq.html


=======================================


Medline Plus Health Information – A service of the U.S. national
Library of Medicine and the National Institutes of Health

BPH: Benign prostatic hypertrophy (BPH) is a non-cancerous enlargement
of the prostate gland, commonly found in men over the age of 50.
http://www.nlm.nih.gov/medlineplus/ency/imagepages/18005.htm



Prostate cancer: There is no known association with benign prostatic
hyperplasia (BPH). http://www.nlm.nih.gov/medlineplus/ency/article/000380.htm


=======================================


“An enlarged prostate gland is a common condition, affecting the
lifestyles and, to some degree, the health of many men over the age of
60. It can play havoc on a man's ability to urinate with ease and, in
some cases, can lead to serious medical complications.”

“However, the condition is not cancerous. And there are many methods
to improve the flow of urine if it does become obstructed by an
enlarging prostate.”

Is BPH related to prostate cancer? 

“While BPH causes an increase in the number of cells in the part of
the prostate gland that surrounds the urethra, this growth is benign,
or noncancerous. This is because the cell growth is controlled by the
body. In cancer, cell growth is uncontrolled.”

“Therefore, BPH cannot "turn into" prostate cancer.”
 
“However, BPH and prostate cancer can certainly exist side by side.
Also, it is possible for a man diagnosed with BPH to develop prostate
cancer at a later date.”

“It is important for all men over age 50 (or over age 40, for those at
higher risk) to have regular checks for prostate cancer as part of
their overall wellness plan.”

“The incidence of BPH is at least 50 percent for all men at the age of
50 and rises to at least 80 percent of all men in their eighth decade
of life.”

Your Medical Source: Library
http://www.yourmedicalsource.com/library/prostateenlargement/BPH_whatis.html


=======================================


“A large gland may not only cause urinary blockage, but it can also be
mistaken for prostate cancer. Large prostates have an abundance of
glandular tissue and tend to produce more PSA. Since PSA elevation in
the blood is used to screen for prostate cancer, the elevation of PSA
levels due to an enlarged gland can interfere with effective
screening. A recent study of aging among normal volunteers has found a
51% incidence of BPH in men 60-69 years of age. This means that one
out of two men in this age group will have BPH. The incidence of BPH
has been shown to be as high as 80% in men aged above 80 years .”
http://www.mycweb.com/megillah/jul2000/diseases_of_the_prostate_gland_in_men.html


=======================================


The Prostate Enlargement Fact Sheet provides basic information about
the prostate gland and describes symptoms, diagnosis, and treatment of
prostate enlargement, including new sections on medications that
shrink or relax prostate tissue, and nonsurgical procedures like
transurethral microwave thermotherapy to remove excess prostate
tissue.
 
Prostate Enlargement - Benign Prostatic Hyperplasia Fact Sheet

“It is common for the prostate gland to become enlarged as a man ages.
Doctors call the condition benign prostatic hyperplasia (BPH), or
benign prostatic hypertrophy.”

“The symptoms of BPH vary, but the most common ones involve changes or
problems with urination, such as

a hesitant, interrupted, weak stream 
urgency and leaking or dribbling 
more frequent urination, especially at night”
 
“The size of the prostate does not always determine how severe the
obstruction or the symptoms will be. Some men with greatly enlarged
glands have little obstruction and few symptoms while others, whose
glands are less enlarged, have more blockage and greater problems.”

Prostate Specific Antigen (PSA) Blood Test

“In order to rule out cancer as a cause of urinary symptoms, your
doctor may recommend a PSA blood test. PSA, a protein produced by
prostate cells, is frequently present at elevated levels in the blood
of men who have prostate cancer.”

BPH and Prostate Cancer: No Apparent Relation

“Although some of the signs of BPH and prostate cancer are the same,
having BPH does not seem to increase the chances of getting prostate
cancer. Nevertheless, a man who has BPH may have undetected prostate
cancer at the same time or may develop prostate cancer in the future.
For this reason, the National Cancer Institute and the American Cancer
Society recommend that all men over 40 have a rectal exam once a year
to screen for prostate cancer.”


National Institute of Diabetes and Digestive and Kidney Diseases of
the National Institutes of Health
http://www.niddk.nih.gov/health/urolog/pubs/prostate/index.htm


=======================================


The Internet Pathology Laboratory for Medical Education  
Florida State University College of Medicine 
Case of the Week

“Prostatic hyperplasia does not appear to be a precursor to prostate
carcinoma, though both seen in older males.”
http://medlib.med.utah.edu/WebPath/COW/COW094.html


=======================================

Prospective Clinical Studies of BPH and Prostate Cancer
 
“NIDDK is working with the National Cancer Institute (NCI) to find
better ways to identify and diagnose early signs of prostate cancer.
The prospective study builds on an existing DKUHD program, the Medical
Therapy of Prostate Symptoms (MTOPS) study, which supports 19 clinical
centers examining the effects of two different drugs prescribed to
relieve symptoms of prostate enlargement. While MTOPS was originally
designed to compare the effectiveness of two BPH drugs, the assembled
cohort creates a rare opportunity to study the early stages of a
condition that often goes undetected until it has reached an advanced
stage. Over the next 10 years, a substantial portion of the men in
this study are expected to develop prostate cancer. The baseline
studies of these men, including prostate biopsy and ultrasound
imaging, may help researchers identify surrogate markers for the
prediction of prostate cancer risk.”
http://www.niddk.nih.gov/health/kidney/Research_Updates/winter99_00/2.htm


=======================================


Prostate. 2001 Nov 1;49(3):208-12.  Related Articles, Links  
Prostate volume and prostate-specific antigen in the absence of
prostate cancer: a review of the relationship and prediction of
long-term outcomes.
Lieber MM, Jacobsen SJ, Roberts RO, Rhodes T, Girman CJ.
Department of Urology, Mayo Clinic, Rochester, MN, USA.

“BACKGROUND: The risk for long-term outcomes associated with benign
prostatic hyperplasia (BPH) has not been well characterized.
Untreated, BPH can lead to complications and negative outcomes, such
as deterioration of bladder function, urinary tract infection, acute
urinary retention (AUR), and surgery.
RESULTS: In the studies reviewed, men with moderate to severe
symptoms, depressed uroflow, prostatic enlargement and elevated PSA
were at greater risk for developing subsequent AUR or surgery. Men
with prostatic enlargement had a 3-fold higher risk for acute urinary
retention and were 4 times more likely to have had any treatment for
BPH.
CONCLUSIONS: The results of these studies may assist physicians in
discussing treatment options as well as long-term complications with
patients.”

PubMed - indexed for MEDLINE
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11746266&dopt=Abstract


=======================================


Additional Information that may interest you:

What Causes The Prostate To Enlarge?
http://www.yourmedicalsource.com/library/prostateenlargement/BPH_causes.html


Enlarged Prostate (BPH) 
The latest medical news and information for patients or
friends/parents of patients diagnosed with enlarged prostate (BPH).
http://www.docguide.com/news/content.nsf/PatientResAllCateg/Enlarged%20Prostate%20(BPH)?OpenDocument


=======================================


Search Criteria:
Prostate enlargement and Cancer 
BPH and Prostate Cancer
prostate enlargement associated with prostatic carcinoma
Nodular hyperplasia precursor to carcinoma.
relationship between nodular hyperplasia and carcinoma 


I hope this helps. If anything is unclear please request clarification
and I'll be glad to offer further assistance before you rate my answer
and close the question.


Best Regards,
Bobbie7-ga
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