Hello alephomega!!
It is always a pleasure for me to know that the asker find my work
helpful. Thank you for the good opinion given to my proposed answer.
Here I will transcribe the answer:
There are several possible causes for the glossopharyngeal neuralgia.
I will sum up the "Pathogenesis" paragraph of the article provided by
you in order to set a background:
"Glossopharyngeal neuralgia usually occurs without any obvious cause.
A thorough physical examination usually does not reveal any
abnormality other than the identification of trigger points.
Radiological examination including CT scans, MRIs, and angiograms will
be normal.
Why then does the nerve go into a state of hyperexcitability causing
idiopathic glossopharyngeal neuralgia?
...it became apparent that most of these cases of idiopathic
glossopharyngeal neuralgia could be caused by vascular compression of
the glossopharyngeal nerve at the nerve root entry zone, causing a
hyperactive rhizopathy. The implicating vessel is usually the
posterior inferior cerebellar artery (PICA) which frequently also
compresses on the rootlets of the vagus nerve. It is impossible to
image that radiologically...These syndromes are quite effectively
treated by a microvascular decompression procedure of the relevant
vessels...it is important to exclude secondary causes of
glossopharyngeal neuralgia. Any sort of compression or irritation to
the glossopharyngeal nerve can result in neural hyper-excitability and
neuralgia. The most common secondary cause of neuralgia is the Eagles
syndrome or styalgia. It is a glossopharyngeal nerve
hyper-excitability syndrome caused by compression of the nerve against
an elongated or fractured styloid process or a calcified stylo-hyoid
ligament.
Other causes of secondary glossopharyngeal neuralgia include:
cerebellopontine angle tumours, parapharyngeal space lesions,
metastasis to petrous temporal bone from breast carcinoma,
post-tonsillectomy, local infection, carcinoma of the parapharyngeal
space, carcinoma of the pharynx, nasopharyngeal carcinoma, posterior
fossa arterio-venous malformation."
From "The Glossopharyngeal Nerve, Glossopharyngeal Neuralgia and the
Eagles Syndrome - Current Concepts and Management":
http://www.sma.org.sg/smj/4010/articles/4010ra1.htm
After researching I found that some new things can be added to update
the statements of this nice article.
I will start with the Diagnosis.
In order to rule out secondary causes of the glossopharyngeal
neuralgia several studies may be taken, this studies includes physical
examination, CAT Scan, X-Ray and MRI. None of these is able to
determine if glossopharyngeal neuralgia is caused by vascular
compression of the glossopharyngeal nerve at the nerve root entry
zone.
Several techniques was developed to do this (and more are in the first
states of development), and they are having success diagnosing the
vascular compression of the glossopharyngeal nerve.
One of the most effective techniques is the MRI/MRA (MRI and Magnetic
Resonance Angiography combined)
"Diagnosis & Tests:
Tests should be done to identify an abnormality at the base of the
skull, particularly tumors. These may include X-rays, CAT scan of the
head, and head MRI. Sometimes the MRI may show evidence of
inflammation of the glossopharyngeal nerve.
To determine whether a blood vessel is compressing the nerve, some
pictures of the brain arteries can be obtained using techniques, such
as magnetic resonance angiography (MRA) or conventional angiography
(X-rays of the arteries with a dye).
Occasionally, certain blood tests may be needed when the diagnosis is
not clear, to rule out other causes of peripheral nerve problems
(neuropathy), such as high blood sugar."
"Glossopharyngeal Neuralgia: Diagnosis"
http://www.1uphealth.com/health/glossopharyngeal_neuralgia_diagnosis_tests.html
Once Glossopharyngeal Neuralgia is diagnosed, depending on the cause
of the condition, the appropriate treatment is applied:
"Treatment:
Initial treatment of Glossopharyngeal Neuralgia is medical with
carbamazepine (Tegretol®) and gabapentin (Neurontin®) being the
medications of choice. Unfortunately, these medications are not as
effective for Glossopharyngeal Neuralgia as they are for Trigeminal
Neuralgia. As a result, the majority of patients require Microvascular
Decompression (MVD) which is the only advisable surgical procedure.
Microvascular Decompression:
This procedure involves entering the skull behind the ear and locating
a loop of blood vessel contacting the root entry zone of the 9th
cranial nerve. The blood vessel is lifted away and padded a safe
distance off the nerve with a Teflon® felt sponge. The incision is
closed watertight. Most patients will experience immediate relief of
their pain after this procedure. The first night post-operatively is
spent in the intensive care unit for observation. Most people will be
discharged home by the third post-operative day."
From the UCSD Division of Neurosurgery website:
http://www.neurosurgery.ucsd.edu/cnd/glossopharyngeal_neuralgia.htm
See also the followimg pages from the Department of Neurosurgery,
University of Pittsburgh website:
"Glossopharyngeal Neuralgia":
"...We believe MVD for GN is the most effective treatment for this
disorder. Despite the rarity of GN, we have operated upon over 200
patients with throat pain over 80% of whom enjoy immediate excellent
relief."
http://www.neurosurgery.pitt.edu/cranialnerve/disorders/glossneuralgia.html
"Video of MVD Procedure":
http://videoserver.upmc.com/ramgen/neuro/lmimcs.rm
"Center for Cranial Nerve Disorders and Microvascular Surgery ":
"The pioneering work accomplished by University of Pittsburgh faculty
over the past quarter century has established the University of
Pittsburgh Center for Cranial Nerve Disorders and Microvascular
Surgery as the international leader in the management of trigeminal
neuralgia, hemifacial spasm and glossopharyngeal neuralgia. There has
been a significant evolution in the treatment of these conditions over
the past thirty years, now under the direction of Dr. Amin Kassam."
http://www.neurosurgery.pitt.edu/cranialnerve/index.html
Contact and Referral Information for the Center for Cranial Nerve
Disorders and Microvascular Surgery:
-For Appointments:
Debbie McHugh
Appointment Secretary
(412) 647-6778
mchughdl@upmc.edu
-For General Information:
Lois E. Burkhart, RN
Nurse Coordinator
(412) 647-6776
burkhartle@upmc.edu
-Address:
UPMC Presbyterian, Suite B-400
200 Lothrop Street
Pittsburgh, PA 15213
-Telephone:
(412) 647-6778 or (412) 647-6776
-Fax:
(412) 647-0989
If you want to arrange a consultation with surgeons of this Centre,
please visit the following page:
"How to Arrange a Consultation and What to Expect Once in Pittsburgh":
http://www.neurosurgery.pitt.edu/cranialnerve/consultation.html
There are another treatment, the rhyzotomy, you can read about it at
the following page from the Centre for Cranial Nerve Disorders,
Winnipeg, University of Manitoba, Health Sciences Centre:
"TREATMENTS FOR GPN"
http://www.umanitoba.ca/centres/cranial_nerves/glossopharyngeal_neuralgia/treatments.html
Regrading to the list of reputable institutions and/or neurologist, I
select the institutions and individuals that have contributed with
research about this condition or have a good reputation in this field.
I found the following:
South Africa:
"The South African Society of Otorhinolaryngology Head and Neck
Surgery":
One of the members of the Executive Committee of this society has
claimed the following:
"I am an ENT Surgeon and recently had a patient with glossopharyngeal
neuralgia. I will be approaching the transection of the nerve through
a simple tonsillectomy. Once the fibres of the superior and middle
constrictors are identified, the nerve will be seen ermerging between
them. If cut at this level a vast majority of patients will recover.
dr. shanil ramjettan <sramjet@iafrica.com>
durban, south africa "
CONTACT DETAILS: The ENT official postal address
PO BOX 751191
Garden View
South Africa
2047
Tel 27-11-6226314
fax 27-11-6167780
bryanm@iafrica.com
Dr Roger L. Melvill:
212 Constantiaberg
Medi-Clinic
Burnham Road
Plumstead, 7800
Cape Town
South Africa
Telephone
+27 (21) 7974330
Facsimile
+27 (21) 7622750
email: melvillr@iafrica.com
See his webpage "The Neurosurgery SA On Line Website":
http://www.neurosurgery.co.za/index.html
Europe:
United Kingdom:
Department of Neurosurgery, Frenchay Hospital, Frenchay, Bristol, UK:
Phone +44 117 970 1212
Email: nitin.patel@neurosurgery.uk.net
http://www.neurosurgery.uk.net/index.php
"CONSULTANT NEUROSURGEONS" page:
http://www.neurosurgery.uk.net/consultants.php
You can also contact the "Trigeminal Neuralgia Association UK"
PO Box 413
Bromley
BR2 9XS
England
Available Contact Numbers
Head Office: 020 8462 9122
Visit this page to Contact any Member of the Executive Committee at
the Trigeminal Neuralgia Association UK:
http://www.tna.org.uk/modules.php?name=Contact
France:
Groupe Hospitalier Pitié-Salpétrière, Paris
Directeur Mme Anne-Marie ARMANTERAS de SAXCE
Adresse 47-83, boulevard de l'Hôpital
75 PARIS 13ème
Adresse postale 47-83, boulevard de l'Hôpital
75651 PARIS Cedex 13
Téléphone 01 42 16 00 00
Hôpital de Hôpital d'aigus, soins de suite et de réadaptation, soins
de longue durée
http://www.ap-hop-paris.fr/structure/hopital.asp?hopital=066
SERVICE : NEURO-CHIRURGIE
CHEF DE SERVICE Pr Rémy VAN EFFENTERRE
Tel : 01 42 16 34 06
Fax : 01 42 16 33 41
http://www.ap-hop-paris.fr/structure/service.asp?hopital=066&service=0033
Doctors from this service have published the following article:
"Glossopharyngeal neuralgia associated with a vascular loop
demonstrated by magnetic resonance imaging.
Boch AL, Oppenheim C, Biondi A, Marsault C, Philippon J.
We report two cases of glossopharyngeal neuralgia associated with a
vascular loop of the postero-inferior cerebellar artery, diagnosed by
magnetic resonance imaging. Reviewing the literature, we found this to
be the first report of a magnetic resonance-validated vascular
abnormality related to such a condition. One patient was cured by
surgical decompression, confirming the role of the abnormal vessel in
the pain. As with trigeminal neuralgia, a possible vascular etiology
should be considered in glossopharyngeal neuralgia."
USA:
The most recommended is the mentioned Center for Cranial Nerve
Disorders and Microvascular Surgery of the University of Pittsburg.
http://www.neurosurgery.pitt.edu/cranialnerve/contact.html
UCSD Division of Neurosurgery:
Providing surgical evaluation, pre-operative, operative, and
post-operative care for disorders of the brain, spine, and peripheral
nerves.
UCSD Medical Center
Division of Neurosurgery, Mailcode 8893
200 West Arbor Drive
San Diego, CA 92103-8893
(619) 543-5540 office
(619) 543-2769 fax
email Maryellen McLaughlin at: mmclaughlin@ucsd.edu
http://www.neurosurgery.ucsd.edu/
Jho Institute for Minimally Invasive Neurosurgery:
Director: Hae-Dong Jho, M.D., Ph.D.
Professor of Neurosurgery
Drexel University School of Medicine
(previously MCP-Hahnemann Medical School)
Allegheny General Hospital
http://drjho.com/index.htm
Address JHO Institute for Minimally Invasive Neurosurgery
7th Floor, Snyder Pavilion
Allegheny General Hospital
320 East North Avenue
Pittsburgh, PA 15212-4772
Manager: Robin A. Coret
e-mail : rcoret@DrJho.com
Tel : (412) 359-6110
Fax : (412) 359-8339
Contact Dr. Jho via e-mail DrJho@DrJho.com
Visit this page for more info:
"Trigeminal Neuralgia, Dr. Jho's Endoscopic Micro-Vascular
Decompression":
http://drjho.com/tic_surgery_or_trigeminal_neuralgia_surgery.htm
See also the following organizations:
American Chronic Pain Association (ACPA)
P.O. Box 850
Rocklin, CA 95677-0850
ACPA@pacbell.net
http://www.theacpa.org
Tel: 916-632-0922 800-533-3231
Fax: 916-632-3208
National Chronic Pain Outreach Association (NCPOA)
P.O. Box 274
Millboro, VA 24460
ncpoa@cfw.com
http://www.chronicpain.org
Tel: 540-862-9437
Fax: 540-862-9485
Search strategy:
KEYWORDS
"glossopharyngeal neuralgia"
"glossopharyngeal neuralgia" treatment
"glossopharyngeal neuralgia" diagnosis
"glossopharyngeal neuralgia" MRI MRA
glossopharyngeal pain
SEARCH ENGINE
www.google.com
Thank you for the oportunity to answer your interesting questions.
Please feel free to request for all the clarifications that you think
are needed.
Best regards.
livioflores-ga |
Clarification of Answer by
livioflores-ga
on
11 Aug 2003 22:33 PDT
Hi again alephomega!!
I want to add a link to some articles that will give you more valuable
info related to the GPN:
Please go to the SpringerLink Homepage:
http://www.springerlink.com
Then in the "Search for" box located at the top of the page type the
words (without quetes) "glossopharyngeal neuralgia", you will lead to
the "SpringerLink - Search Results - Criteria: glossopharyngeal
neuralgia" page. At this page you will see a list with the following
articles:
·Glossopharyngeal Neuralgia Associated with a Vascular Loop
Demonstrated by Magnetic Resonance Imaging (by A.-L. Boch, C.
Oppenheim, A. Biondi, et al.)
·Glossopharyngeal Neuralgia Caused by Adhesive Arachnoid (by H.
Fukuda, M. Ishikawa, N. Yamazoe)
·Microvascular Decompression for Treating Glossopharyngeal Neuralgia
Complicated by Sick Sinus Syndrome (by Y. Nishikawa, M. Suzuki, N.
Kuwata, et al.)
·Possible Role of an Endovascular Provocative Test in the Diagnosis of
Glossopharyngeal Neuralgia as a Vascular Compression Syndrome (by T.
Matsushima, Y. Goto, H. Ishioka, et al.)
·Chiari type I presenting as left glossopharyngeal neuralgia with
cardiac syncope (by Paulo Aguiar, Oswaldo Tella, Carlos Pereira, Fábio
Godinho, Renata Simm)
·Surgical Treatment of Glossopharyngeal Neuralgia as Vascular
Compression Syndrome via Transcondylar Fossa (Supracondylar
Transjugular Tubercle) Approach (by T. Matsushima, Y. Goto, Y. Natori,
et al.)
·Sudden Onset Pharyngeal Pain Associated with Dissecting Vertebral
Artery Aneurysm (Y. Soga, Y. Ito)
If you want to read one of these articles just click on the title of
the one that you want to see and a new page will be showed, just do
another click on the "(Open)Entire Document" button on the right side
of the page.
You have to be instaled the Acrobat Reader software to read the
articles.
If you have troubles with this pages, please let me know and I will
gladly answer your queries.
Best regards.
livioflores-ga
|