Category: Science > Biology
Asked by: danen-ga
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13 Aug 2003 07:47 PDT
Expires: 12 Sep 2003 07:47 PDT
Question ID: 244223
What is the number of macrophages in the human body?
Answered By: tehuti-ga on 13 Aug 2003 09:15 PDT
Hello danen, According to data from Wintrobe's Clinical Hematology, Ninth Edition, edited by G.R. Lee, T.C. Bithell, J. Foerster, J.W. Athens, J.N. Lukens and published by Lea & Febiger, Philadelphia PA, 1993, which is cited by Robert A. Freitas Jr in Nanomedicine, Volume I: Basic Capabilities, published by Landes Bioscience, Georgetown, TX, 1999: there are approximately "0.2 trillion macrophages and other reticuloendothelial (mononuclear phagocyte) cells throughout the human tissues" Freitas also gives a total white blood cell count of 0.4 trillion in the blood. Monocytes, which are precursors of macrophages, make up approximately 2-8% of that total, ie about 8-32 billion monocytes in total. Their numbers will vary with the general status of health. The Freitas figures for numbers of different cells in the body are available online: http://www.nanomedicine.com/NMI/8.5.1.htm The "other reticuloendothelial (mononuclear phagocyte) cells" will include cells that resemble macrophages and have similar functions, such as the Kupfer cells in the liver. Search strategy: total macrophages "in the human body" I hope this is the information that you are seeking.
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From: emptycagegirl-ga on 06 Sep 2003 16:51 PDT
Blood Breakdown.. plasma matrix = 55% rbc's +wbc's = 45% Erythrocytes (Red blood cells) 4.4-5.5 million mer mm^3 Leukocytes (White blood cells) 5,000-10,000 per mm^3, Neutrophils 60-70% total Leukocyte count (act as phagocytes in the body tissues), Eosinophils 2-4% total Leukocyte count (kill internal parasites and detoxification of basophilic bi-products), Basophils 1% total Leukocyte count (Non-specific Inflammatory response), Lymphocytes 25-30% total leukocyte count (Specific immune response), Monocytes 5% total leukocyte count (become phagocytic macrophages of connective tissue at injury sites)
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