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Subject:
Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
Category: Health > Medicine Asked by: shoe-ga List Price: $6.00 |
Posted:
14 Jun 2002 12:28 PDT
Expires: 21 Jun 2002 12:28 PDT Question ID: 26017 |
How does the prescription drug Bupropion ( Amfebutamone, Wellbutrin, Zyban ) mimic Cocaine? I know that their physiological action is very similar. I also know that Bupropion is prescribed for Cocaine Withdrawal. I want to find a study that discusses: 1. Compares what that physiological action of these two drugs is. 2. Does this lead to any cause for addiction on the part of Bupropion? 3. Was the Drug Maker open to any criticism due to the similarity? Alas, an explanation of the physiological effects of Buproprion is not what I need. I want a study that compares specifically Cocaine and Buproprion. Thanks! Add comments and I will get back to you. |
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Subject:
Re: Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
Answered By: knowledge_seeker-ga on 14 Jun 2002 13:44 PDT Rated: |
Hi! This is just what you need this study discusses the physiological action of the two drugs and compares their addictive effects Inhibition of dopamine (DA) transporter function is thought to be the principal mechanism underlying cocaine's addictive effects. In contrast to cocaine, several other inhibitors of DA transporter function are not considered to possess abuse liability .In the present study, we investigated the reinforcing and neuroadaptive effects of two other DA reuptake inhibitors, namely bupropion and nomifensine. Abstract: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9103538&dopt=Abstract Article: http://jpet.aspetjournals.org/cgi/content/full/281/1/508 I am not a scientist so hesitate to translate their results. I refer you to the Discussion section of the above study. There the researchers discuss the addictive quality of Bupropion and why it is, apparently, not as addictive as Cocaine. I also refer you to Pubmed for further similar studies: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=&DB=PubMed Use their search function and terms: Bupropion similar to Cocaine In case you arent familiar with the term used throughout most of the above research studies, self-administration is used in animal studies of addictive substances. The subject animals are given a means of self-administering drugs and the frequency of those ministrations is measured. Regarding the Drug Maker being criticized: Bupropion is made and marketed under various trade names by a number of pharmaceutical companies. In addition to the use you cite above, it is an antidepressant and is used in the treatment of bipolar disorder. It is also used to help people to stop smoking. I was unable to find any mention of criticism for its similarity to cocaine. Here is a list of news articles where Bupropion is mention. As you can see, the only concern is over possible side effects. http://ask.elibrary.com/search.asp?refid=mni-search&RO=DocDate&datetype=18&srcbooks=checked&srcmags=checked&srcnews=checked&srcpics=checked&srctvrad=checked&query=Bupropion I hope this has answered your question and given you some useful avenues for finding more information. Regards, -K~ Search criteria: PubMed Bupropion similar to cocaine Google: Bupropion |
shoe-ga
rated this answer:
No question. Great Answer. Good utilizations of med searches. |
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Subject:
Re: Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
From: wengland-ga on 14 Jun 2002 13:03 PDT |
Greetings! I was going to answer this for you, but the information I come up with does not meet your criteria. 1) Bupropion is a dopamine inhibitor, as is cocaine. 2) Several studies have been done using it to treat cocaine abuse. It is not proven to be effective. 3) Little is known as to why Bupropion is not addictive, as cocaine is. 4) No one study answers all of your questions. Some intersting reading, tho: Cocaine, ADHD and Buproprion http://www.asam.org/jol/Articles/JAD%2021(2)%20Article1.pdf Discussion of Buproprion, comparing it to cocaine: http://www.nomifensine.com/merital.htm Good luck finding the information you seek! |
Subject:
Re: Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
From: atate-ga on 23 Jun 2002 22:21 PDT |
Just a quick correction of the above comment... Bupropion and cocaine are both dopamine REUPTAKE inhibitors. This is quite different than a dopamine inhibitor. A reuptake inhibitor will prevent synaptic dopamine from being endocytosed and removed from the synaptic cleft, the final result being an increase in the concentration and action of dopamine between neurons. A traditional "inhibitor" would generally either compete for the dopamine receptor without activating it, actually deactivate the receptor, or in some other way reduce the action of dopamine (not something generally desirable). Just some other stuff that might be valuable (I like pharmacology) : The exact mechanism of both Zyban/Wellbutrin/Bupropion/Whateveritscalled and cocaine (as far as the psychotropic effects) is unknown. So IMHO is isn't really that relivant to compare their action until we fully understand the pharmacological activities. Both cocaine and Bupropion have a significant effect on serotonin and norepinephrine in addition to dopamine. Both of these neurotransmitters can contribute to any physiological similarity between the two. Also there has been some debate as to the adrenergic mechanism of cocaine. Here are some articles. http://unisci.com/stories/20021/0307026.htm http://www.rxlist.com/cgi/generic/buprop_cp.htm Good luck. A. Tate |
Subject:
Re: Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
From: atate-ga on 23 Jun 2002 22:24 PDT |
That should read "...is isn't really that relevant to compare...." Relevant has an e. Typo. Oops. AT |
Subject:
Re: Bupropion ( Amfebutamone, Wellbutrin, Zyban ) and Cocaine.
From: computergod2-ga on 15 Dec 2004 16:04 PST |
Bupropion is abusable and addictive. The route of administration (and the resulting variance in the time it is in the bloodstream) can make the effects simular. http://s92551074.onlinehome.us/Wellbutrin_-_Processing_it_into_a_pure_form_.html |
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