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Q: control of striated muscle ( Answered,   0 Comments )
Question  
Subject: control of striated muscle
Category: Science > Biology
Asked by: jkhansard-ga
List Price: $2.00
Posted: 28 Sep 2003 00:07 PDT
Expires: 27 Oct 2003 23:07 PST
Question ID: 260901
what would happen if you bathed the inside of the muscle fiber with EGTA?
Answer  
Subject: Re: control of striated muscle
Answered By: synarchy-ga on 29 Sep 2003 18:41 PDT
 
Hello -

Calcium is necessary for the contraction of muscle - EGTA is a
chelator (compound which binds to metals) that effectively "depletes"
the calcium.  If EGTA is put into a muscle cell, it will "sop up" the
calcium, producing a decrease in contractile force and muscle
relaxation.



One nice page:
http://www.biosci.ohio-state.edu/~patches/eeob410/muscle.html

A longer description:
http://www.uic.edu/classes/phyb/phyb516/regulationmusclecontru3.htm

A historical account of the investigations that led to our
understanding of the role of calcium in muscle contraction (used
EGTA):
http://www.actabp.pl/pdf/3_2000/493-516s.pdf

synarchy

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EGTA muscle contraction
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