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| Subject:
Liver Transplants Worldwide
Category: Health Asked by: sogoam-ga List Price: $30.00 |
Posted:
31 Oct 2003 10:01 PST
Expires: 30 Nov 2003 10:01 PST Question ID: 271457 |
I am interested in finding out about liver transplants. I need to know about how many liver transplants are successful when transplanted, and how many fail. I need this information not only in the US but worldwide. It is not enough tell me how many transplants were performed. I need to know how many of these were successful. Are there any predictors to know which are successful and which are going to be rejected? | |
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| Subject:
Re: Liver Transplants Worldwide
Answered By: czh-ga on 11 Nov 2003 16:26 PST |
Hello sogoam-ga, I'm glad that you found the information helpful. I'm posting my comment as the answer. Thank you for the go ahead. ~ czh ~ Hello again sogoam-ga, I?m posting this as a comment rather than an answer because I haven?t been able to find information to cover every aspect of your question. Please let me know if the information I?ve collected is satisfactory so that you will accept it as an answer. It is very difficult to gather ?1 yr, 2 yr, and 5yr liver transplant success rate for adults in the US, Western Europe, and Japan? because there are so many variables involved. The statistics are gathered by demographic and other characteristics of both the donor and the recipient. Some of the statistics are kept by the nature of the illness causing the need for the liver transplant. Most of the statistics are collected by the institutions performing the operations and it is difficult to get cumulative statistics by geographic location. I?ve found some resources for US and European statistics that will give you some insights on the trends in liver transplant survival rates. Your best bet for getting exactly the information you?re looking for may be to contact United Network for Organ Sharing (UNOS) Scientific Registry on Organ Transplantation for US Statistics and Eurotransplant for Europe. Japan is a special case because of the legal and cultural climate for transplants. Japan?s first Organ Transplant Law took effect in October 1997 but organ transplantation from deceased donors lags far behind the US and Europe. On the other hand, Japan has been much more active in live liver donor transplantation. I?ve included some statistics I?ve found on survival rates for these procedures. I think the resources I?ve collected will give you a good overview of current trends with liver transplants but I?m not confident that I?ve found all the information you requested for specific survival rates by geographic region so I?m posting this as a comment. Please tell me if you find this information sufficient to meet your needs so that I can post this as an answer. Wishing you success for your project. ~ czh ~ ============================================== COMPILING LIVER TRANSPLANT SURVIVAL STATISTICS ============================================== http://www.medscape.com/viewarticle/414302?WebLogicSession=P6qXNAQocHNPuSfOn1B30O1JVKeWPuKpf4BcyhZmL1gel4N8Yeyr|1931277225410312065/184161395/6/7001/7001/7002/7002/7001/-1 I'm trying to find a source for data describing the worldwide statistics of organ transplantation. Can you please help me? Response from Francis Leo Delmonico, MD, 03/15/2000 The worldwide statistics on organ transplantation would likely have to be an ad hoc compilation of multiple databases: the United Network for Organ Sharing (UNOS) Scientific Registry on Organ Transplantation, Eurotransplant and others. By organ specificity there are international registries for kidney, pancreas, liver, heart and lung transplantation. Selected transplantation registries and databases are described below. http://www.transweb.org/qa/qa_txp/liveliverdonor.html Living Liver Donation Statistics: Overall, what are the graft survival stats at 1 yr? 3 yrs? 5 yrs.? No meaningful data exists, but since the published retransplant rate is about 15%, it would follow that the graft survival is about 15% less than the patient survival, which is approximately the same as with cadaver liver transplantation. =========================================== LIVER TRANSPLANT STATISTICS ? UNITED STATES =========================================== http://www.unos.org/data/ United Network for Organ Sharing Have special data needs? You can request specific, custom data reports, and STAR data files by completing the form below or calling UNOS. ***** I suggest that you contact UNOS for the specific information you need. See below for samples of the types of data they have available. ---------------------------------------- http://www.optn.org/data/annualReport.asp?url=/data/AR2002/ar02_main_organ.htm Annual Report 9.7 Death and Death Rates for Liver Recipients 9.8a Graft Survival Rates, Deceased Donor Liver Transplants 9.8b Graft Survival Rates, Living Donor Liver Transplants 9.9a Patient Survival Rates, Deceased Donor Liver Transplants 9.9b Patient Survival Rates, Living Donor Liver Transplants ***** Each of these tables leads to you a selection menu of 10+ variables. Defining survival rates is a very complex issue. -------------------------------------- http://www.optn.org/organDatasource/about.asp?display=Liver Organ Procurement and Transplantation Network Organ Datasource ? Liver http://www.optn.org/organDatasource/centerDataSelect.asp Transplant Center ***** Very extensive statistics are available for each transplant center and some cumulative data are available by region. The variables are enormous and it?s difficult to arrive at national survival rates. -------------------------------------------- http://www.unos.org/data/ar2002/ar02_chapter_nine.htm CHAPTER IX Analytical Approaches for Transplant Research ***** This article discusses the difficulties of categorizing and analyzing transplant data. ------------------------------------------------ http://216.239.41.104/search?q=cache:5E07Pf1VFF0J:www.upmc.edu/newsbureau/tx/lvrrtbg.htm+liver+transplant+survival+rates&hl=en&ie=UTF-8 The one-year liver transplant patient survival rate at the UPMC was 78.5 percent, compared to the 76.7 percent national rate and the 74.1 percent rate that would be expected given the complicated nature of the cases at the UPMC. The two-year survival rate was 73.8 percent, higher than the 68.7 percent expected rate and the national rate of 71.8 percent. UPMC and national patient survival rates at three years were comparable, at 67.7 percent and 67.5 percent, respectively, but still higher than the expected rate of 63.9 percent. The primary objective of the study was to determine survival in an unselected patient population who had liver transplantation for HCC. Using the United Network for Organ Sharing (UNOS) database, researchers collected data on 48,887 patients who underwent liver transplantation in the United States between 1987 and 2001. Patients were excluded if they had undergone multiple organ transplantation, retransplantation, were less than 18 years of age, or lacked survival information. ------------------------------------------------ http://www.innovations-report.com/html/reports/medicine_health/report-22829.html Of the remaining patients included in the final analysis, 985 had liver transplantation for hepatocellular carcinoma (hepatoma group) and 33,339 patients had liver transplantation for other reasons (control group). Both the hepatoma and control groups were divided into three different five-year time periods: 1987 ? 1991, 1992 ? 1996, and 1997 ? 2001. Researchers found significant and steady improvement in survival over time among liver transplant patients with HCC, particularly in the last five years. Five-year survival improved from 25.3 percent during 1987-1991 to 47 percent during 1992-1996, and 61.1 percent during 1996-2001. ==================================== LIVER TRANSPLANT STATISTICS ? EUROPE ==================================== http://www.eurotransplant.nl/index.php?id=liver http://www.eurotransplant.nl/index.php?id=liver Eurotransplant -- Liver http://www.eltr.org/publi/aboutelta.php3 The European Liver Transplant Association is a section of the European Society of Organ Transplantation (ESOT), founded in 1993 in RHODES. The Association is incorporated as European Liver Transplant Association under the law of the British Virgin Islands. http://www.eltr.org/publi/results.php3?id_rubrique=44 Evolution of Liver Transplantation in Europe Patient and graft survival following LT in europe ***** See various tables for European transplant statitistics ---------------------------------------------- http://www.uktransplant.org.uk/useful_links/categories/professional_organisations.htm Professional Transplant Organisations http://www.uktransplant.org.uk/statistics/general_statistics/liver/liver.htm Liver Statistics ***** This site offers limited statistics but you might be able to get additional information by contacting them directly. =================================== LIVER TRANSPLANT STATISTICS ? JAPAN =================================== http://www.medscape.com/viewarticle/409279_1 Improving public awareness of organ transplantation in Japan The Japanese Diet finally passed an organ transplant bill in June 1997. The activities of the Japanese chapter of the Transplant Recipients International Organization have contributed to the promotion of organ transplantation in Japan and to understanding and support for transplantation within the Japanese community as a whole. One obstacle to the advancement of cadaver organ transplantation in Japan is that accurate information about the donation of organs from brain-dead donors and about organ transplantation is not adequately disseminated among the general public and those involved in medical care.[3,4] However, Japan's legislature passed an organ transplant bill in June 1997. The new law, enacted in October 1997, provides that brain death will be recognized only in case of a signed organ donor card. Brain-dead patients who have not agreed in writing to donate organs for transplantation are considered alive and continue to receive treatment. The law also states that family members can overrule a doctor's diagnosis of brain death. ---------------------------------------------- http://www.jef.or.jp/en/jti/199905_003.html Journal of Japanese Trade and Industry ? 1999 May/June Japan's First Legal Organ Transplants Conducted Japan's first organ transplant operations involving a legally declared brain-dead donor took place on February 28. The heart, liver, kidneys and corneas were removed from the donor, who had been officially confirmed brain dead, at the Kochi Red Cross Hospital in Kochi Prefecture on the afternoon of February 28 and immediately transported to five other hospitals, where recipients were waiting. The transplant operations were conducted on the basis of the Organ Transplant Law that took effect in October 1997. Under the law, the donor must have a donor card certifying that he/she has the will to donate his/her organs when he/she dies. The consent of his/her family is also a prerequisite. ------------------------------------------------- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12957090&dopt=Abstract Lancet. 2003 Aug 30;362(9385):687-90. Operative morbidity of living liver donors in Japan. BACKGROUND: Deaths of living liver donors have been reported in western countries, whereas the morbidity and mortality of such donors in Japan, one of the leading countries for living liver transplantation, have not been reported in detail. We aimed to review the operative morbidity and mortality of such donors in Japan. METHODS: 1853 donors of 1852 living liver transplants done in 46 liver transplant centres, and registered in the database of the Japanese Liver Transplantation Society, were assessed for eight donor-related factors of morbidity and mortality. Data for 1841 donors were analysed. FINDINGS: No perioperative mortality was recorded since inception of the liver transplantation programme in Japan from Nov 13, 1989, to April 11, 2002. 244 postoperative complications were reported in 228 (12%) donors. =========================================== LIVER TRANSPLANT STATISTICS ? MISCELLANEOUS =========================================== http://www.pirweb.org/pir05a_overview.htm Worldwide Organ Transplant Statistics (1998): 576 kidney centres have done 411,071 transplants 202 liver centres have done 55,421 236 heart centres have done 44,550 275 bone marrow centres have done 76,927 145 lung centres have done 6,726 ----------------------------------------------- http://www.nzliver.org/ New Zealand Liver Transplant http://www.nzliver.org/outcomes/ Avgs of 104 Patients transplanted: http://www.nzliver.org/discussion.htm LIVE ? DONOR LIVER TRANSPLANTATION -------------------------------------------------------- http://www.sma.org.sg/smj/3902/articles/3902a1.html Liver Transplant in Singapore - Coming of Age K H Lee, S K Lo, S H Quak, Prabhakaran, K C Tan ABSTRACT Background/Aim of Study: Liver transplantation was first performed in 1967, and has become an accepted form of treatment worldwide for chronic liver diseases, acute liver failure and certain metabolic diseases. We document our experience in Singapore over the last 7 years since the first transplant was performed in 1990. Method: Retrospective study at National University Hospital, Singapore. =============== SEARCH STRATEGY =============== liver transplant survivor rates liver transplant success rates liver transplant Europe liver transplant Asia liver transplant Japan live liver transplant |
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| Subject:
Re: Liver Transplants Worldwide
From: p1212-ga on 31 Oct 2003 10:33 PST |
Before doing something extremely radical like a liver transplant, I would seriously investigate alternative methods to cleansing your liver, such as Dr. Richard Schulze's methods: http://www.800herbdoc.com/abp.html You've got nothing to lose tapping this method first. Just my $.02. |
| Subject:
Re: Liver Transplants Worldwide
From: czh-ga on 06 Nov 2003 12:33 PST |
Hello again sogoam-ga, I?m posting this as a comment rather than an answer because I haven?t been able to find information to cover every aspect of your question. Please let me know if the information I?ve collected is satisfactory so that you will accept it as an answer. It is very difficult to gather ?1 yr, 2 yr, and 5yr liver transplant success rate for adults in the US, Western Europe, and Japan? because there are so many variables involved. The statistics are gathered by demographic and other characteristics of both the donor and the recipient. Some of the statistics are kept by the nature of the illness causing the need for the liver transplant. Most of the statistics are collected by the institutions performing the operations and it is difficult to get cumulative statistics by geographic location. I?ve found some resources for US and European statistics that will give you some insights on the trends in liver transplant survival rates. Your best bet for getting exactly the information you?re looking for may be to contact United Network for Organ Sharing (UNOS) Scientific Registry on Organ Transplantation for US Statistics and Eurotransplant for Europe. Japan is a special case because of the legal and cultural climate for transplants. Japan?s first Organ Transplant Law took effect in October 1997 but organ transplantation from deceased donors lags far behind the US and Europe. On the other hand, Japan has been much more active in live liver donor transplantation. I?ve included some statistics I?ve found on survival rates for these procedures. I think the resources I?ve collected will give you a good overview of current trends with liver transplants but I?m not confident that I?ve found all the information you requested for specific survival rates by geographic region so I?m posting this as a comment. Please tell me if you find this information sufficient to meet your needs so that I can post this as an answer. Wishing you success for your project. ~ czh ~ ============================================== COMPILING LIVER TRANSPLANT SURVIVAL STATISTICS ============================================== http://www.medscape.com/viewarticle/414302?WebLogicSession=P6qXNAQocHNPuSfOn1B30O1JVKeWPuKpf4BcyhZmL1gel4N8Yeyr|1931277225410312065/184161395/6/7001/7001/7002/7002/7001/-1 I'm trying to find a source for data describing the worldwide statistics of organ transplantation. Can you please help me? Response from Francis Leo Delmonico, MD, 03/15/2000 The worldwide statistics on organ transplantation would likely have to be an ad hoc compilation of multiple databases: the United Network for Organ Sharing (UNOS) Scientific Registry on Organ Transplantation, Eurotransplant and others. By organ specificity there are international registries for kidney, pancreas, liver, heart and lung transplantation. Selected transplantation registries and databases are described below. http://www.transweb.org/qa/qa_txp/liveliverdonor.html Living Liver Donation Statistics: Overall, what are the graft survival stats at 1 yr? 3 yrs? 5 yrs.? No meaningful data exists, but since the published retransplant rate is about 15%, it would follow that the graft survival is about 15% less than the patient survival, which is approximately the same as with cadaver liver transplantation. =========================================== LIVER TRANSPLANT STATISTICS ? UNITED STATES =========================================== http://www.unos.org/data/ United Network for Organ Sharing Have special data needs? You can request specific, custom data reports, and STAR data files by completing the form below or calling UNOS. ***** I suggest that you contact UNOS for the specific information you need. See below for samples of the types of data they have available. ---------------------------------------- http://www.optn.org/data/annualReport.asp?url=/data/AR2002/ar02_main_organ.htm Annual Report 9.7 Death and Death Rates for Liver Recipients 9.8a Graft Survival Rates, Deceased Donor Liver Transplants 9.8b Graft Survival Rates, Living Donor Liver Transplants 9.9a Patient Survival Rates, Deceased Donor Liver Transplants 9.9b Patient Survival Rates, Living Donor Liver Transplants ***** Each of these tables leads to you a selection menu of 10+ variables. Defining survival rates is a very complex issue. -------------------------------------- http://www.optn.org/organDatasource/about.asp?display=Liver Organ Procurement and Transplantation Network Organ Datasource ? Liver http://www.optn.org/organDatasource/centerDataSelect.asp Transplant Center ***** Very extensive statistics are available for each transplant center and some cumulative data are available by region. The variables are enormous and it?s difficult to arrive at national survival rates. -------------------------------------------- http://www.unos.org/data/ar2002/ar02_chapter_nine.htm CHAPTER IX Analytical Approaches for Transplant Research ***** This article discusses the difficulties of categorizing and analyzing transplant data. ------------------------------------------------ http://216.239.41.104/search?q=cache:5E07Pf1VFF0J:www.upmc.edu/newsbureau/tx/lvrrtbg.htm+liver+transplant+survival+rates&hl=en&ie=UTF-8 The one-year liver transplant patient survival rate at the UPMC was 78.5 percent, compared to the 76.7 percent national rate and the 74.1 percent rate that would be expected given the complicated nature of the cases at the UPMC. The two-year survival rate was 73.8 percent, higher than the 68.7 percent expected rate and the national rate of 71.8 percent. UPMC and national patient survival rates at three years were comparable, at 67.7 percent and 67.5 percent, respectively, but still higher than the expected rate of 63.9 percent. The primary objective of the study was to determine survival in an unselected patient population who had liver transplantation for HCC. Using the United Network for Organ Sharing (UNOS) database, researchers collected data on 48,887 patients who underwent liver transplantation in the United States between 1987 and 2001. Patients were excluded if they had undergone multiple organ transplantation, retransplantation, were less than 18 years of age, or lacked survival information. ------------------------------------------------ http://www.innovations-report.com/html/reports/medicine_health/report-22829.html Of the remaining patients included in the final analysis, 985 had liver transplantation for hepatocellular carcinoma (hepatoma group) and 33,339 patients had liver transplantation for other reasons (control group). Both the hepatoma and control groups were divided into three different five-year time periods: 1987 ? 1991, 1992 ? 1996, and 1997 ? 2001. Researchers found significant and steady improvement in survival over time among liver transplant patients with HCC, particularly in the last five years. Five-year survival improved from 25.3 percent during 1987-1991 to 47 percent during 1992-1996, and 61.1 percent during 1996-2001. ==================================== LIVER TRANSPLANT STATISTICS ? EUROPE ==================================== http://www.eurotransplant.nl/index.php?id=liver http://www.eurotransplant.nl/index.php?id=liver Eurotransplant -- Liver http://www.eltr.org/publi/aboutelta.php3 The European Liver Transplant Association is a section of the European Society of Organ Transplantation (ESOT), founded in 1993 in RHODES. The Association is incorporated as European Liver Transplant Association under the law of the British Virgin Islands. http://www.eltr.org/publi/results.php3?id_rubrique=44 Evolution of Liver Transplantation in Europe Patient and graft survival following LT in europe ***** See various tables for European transplant statitistics ---------------------------------------------- http://www.uktransplant.org.uk/useful_links/categories/professional_organisations.htm Professional Transplant Organisations http://www.uktransplant.org.uk/statistics/general_statistics/liver/liver.htm Liver Statistics ***** This site offers limited statistics but you might be able to get additional information by contacting them directly. =================================== LIVER TRANSPLANT STATISTICS ? JAPAN =================================== http://www.medscape.com/viewarticle/409279_1 Improving public awareness of organ transplantation in Japan The Japanese Diet finally passed an organ transplant bill in June 1997. The activities of the Japanese chapter of the Transplant Recipients International Organization have contributed to the promotion of organ transplantation in Japan and to understanding and support for transplantation within the Japanese community as a whole. One obstacle to the advancement of cadaver organ transplantation in Japan is that accurate information about the donation of organs from brain-dead donors and about organ transplantation is not adequately disseminated among the general public and those involved in medical care.[3,4] However, Japan's legislature passed an organ transplant bill in June 1997. The new law, enacted in October 1997, provides that brain death will be recognized only in case of a signed organ donor card. Brain-dead patients who have not agreed in writing to donate organs for transplantation are considered alive and continue to receive treatment. The law also states that family members can overrule a doctor's diagnosis of brain death. ---------------------------------------------- http://www.jef.or.jp/en/jti/199905_003.html Journal of Japanese Trade and Industry ? 1999 May/June Japan's First Legal Organ Transplants Conducted Japan's first organ transplant operations involving a legally declared brain-dead donor took place on February 28. The heart, liver, kidneys and corneas were removed from the donor, who had been officially confirmed brain dead, at the Kochi Red Cross Hospital in Kochi Prefecture on the afternoon of February 28 and immediately transported to five other hospitals, where recipients were waiting. The transplant operations were conducted on the basis of the Organ Transplant Law that took effect in October 1997. Under the law, the donor must have a donor card certifying that he/she has the will to donate his/her organs when he/she dies. The consent of his/her family is also a prerequisite. ------------------------------------------------- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12957090&dopt=Abstract Lancet. 2003 Aug 30;362(9385):687-90. Operative morbidity of living liver donors in Japan. BACKGROUND: Deaths of living liver donors have been reported in western countries, whereas the morbidity and mortality of such donors in Japan, one of the leading countries for living liver transplantation, have not been reported in detail. We aimed to review the operative morbidity and mortality of such donors in Japan. METHODS: 1853 donors of 1852 living liver transplants done in 46 liver transplant centres, and registered in the database of the Japanese Liver Transplantation Society, were assessed for eight donor-related factors of morbidity and mortality. Data for 1841 donors were analysed. FINDINGS: No perioperative mortality was recorded since inception of the liver transplantation programme in Japan from Nov 13, 1989, to April 11, 2002. 244 postoperative complications were reported in 228 (12%) donors. =========================================== LIVER TRANSPLANT STATISTICS ? MISCELLANEOUS =========================================== http://www.pirweb.org/pir05a_overview.htm Worldwide Organ Transplant Statistics (1998): 576 kidney centres have done 411,071 transplants 202 liver centres have done 55,421 236 heart centres have done 44,550 275 bone marrow centres have done 76,927 145 lung centres have done 6,726 ----------------------------------------------- http://www.nzliver.org/ New Zealand Liver Transplant http://www.nzliver.org/outcomes/ Avgs of 104 Patients transplanted: http://www.nzliver.org/discussion.htm LIVE ? DONOR LIVER TRANSPLANTATION -------------------------------------------------------- http://www.sma.org.sg/smj/3902/articles/3902a1.html Liver Transplant in Singapore - Coming of Age K H Lee, S K Lo, S H Quak, Prabhakaran, K C Tan ABSTRACT Background/Aim of Study: Liver transplantation was first performed in 1967, and has become an accepted form of treatment worldwide for chronic liver diseases, acute liver failure and certain metabolic diseases. We document our experience in Singapore over the last 7 years since the first transplant was performed in 1990. Method: Retrospective study at National University Hospital, Singapore. =============== SEARCH STRATEGY =============== liver transplant survivor rates liver transplant success rates liver transplant Europe liver transplant Asia liver transplant Japan live liver transplant |
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