Guayakiri, or guayaquiri is the name of a street in the Mexican city of Querétaro.
I assume it is written in Spanish.

Hmm, sounds somewhat familiar to Gairyuki, a Zoid I wanna have. hehe.

This is a real stumper that probably requires some specialzied
linguistic background to answer definitively.  One of the problems is
that there are so many native South American languages and native
peoples and many variant spellings of many of them.

The best I can do is hope that a couple of clues that I found might
prove useful to the questioner or to another researcher.

1. "Guayaki" is the name of native South American ethnic group and a
language that was (and, to some extent, is) spoken in the eastern
Andean region of South America.  Here is a thumbnail description:
Ethnologue: ACHÉ: a language of Paraguay
http://www.ethnologue.com/show_language.asp?code=GUQ

2.  One source indicates that "iri" is a suffix in the Guarani family
of languages (of which Guayaki is one) , but I have not found a
translation of it:
"Sufijos átonos [atonic (unstressed) suffixes]: gui, i, icha, iko,
ipo, iri, je, ke, ko, ma, me, mi, mo, na, ne, ndie, ngo, ngu, nte, pa,
pe, pio, po, py, ramo, re, ri, rô, tei, ti, va, vo"
Datamex: Guarani
http://www.datamex.com.py/guarani/neepukuaa/prosodia.html

3.  Aymara is another native South American language of the Andean
region, which is much more extensively documented online.  The suffix
"iri" in that language means "actor,""doer" or "agent," but I have
found no link between the Aymara and Guarani languages:
"Esto porque en aymara -iri es un sufijo quedenota actor/ejecutor, de
manera que siquri, en aymara, significa el tocador/ejecutor de siqu."
Aymara: History
http://www.aymara.org/histo.php


Thus, it seems plausible that Guayakiri denotes someone who was
associated with the Guayaki people, but that is speculation on my
part.

markj-ga

Mexico is in North America, or Mesoamerica, far from the Andes in South America.

Mexico has 62 indigenous languages.

The Indigenous Languages of Mexico.Indigenous Groups
http://www.elbalero.gob.mx/kids/about/html/indigenous/lenguas.html

Otomi would probably be the source of the word, if it is indigenous,
as that is the language of the original people of the area.

hlabadie-ga

Re hlabadie-ga's comment, I certainly didn't mean to leave the
impression that my search for the derivation of the name "Guayakiri"
(and many variations on that name) has been limited to South American
languages.  Rather, I meant to convey simply that the only leads that
resulted from my search for that derivation were found in indigenous
South American languages -- and not in indigenous Mexican or
"Middle-American" languages.

Without the benefit of specialized knowledge, I don't think that it is
implausible to suggest that a street name in a south-central Mexican
city could be derived from a South American language.  It's certainly
a long shot, but one worth reporting, I think.

markj-ga

I found the correct spelling. The correct spelling is "Guayakiri"
(Which surprised me. I would have expected it to end with "-quiri". I
have found nothing else!
crabcakes-ga

My guess is that it's an old native Indian word, in the same fashion
as "Quetzalcoatl" and "Tenochtitlan". When I searched on the word,
results all mentioned an address in Mexico. I suppose it could be
something native Indians or aborigines know about. Might be the name
of something particular to the legends of the area.