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Subject:
Difference between genetic linkage and association
Category: Science > Biology Asked by: svannes-ga List Price: $5.00 |
Posted:
29 Jan 2004 14:36 PST
Expires: 30 Jan 2004 04:16 PST Question ID: 301584 |
I am interested to know what substantive differences exist between the techniques of genetic linkage and genetic association. Both methods are used to determine the relationship between a particular genotype and a phenotype and I know that they are different??I just don?t know how they are different. Help! |
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There is no answer at this time. |
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Subject:
Re: Difference between genetic linkage and association
From: md_phoenix-ga on 29 Jan 2004 20:28 PST |
Although these two concepts are related to each other, they are not the same thing. Term linkage is usually used to talk about movement of genes during recombination events. Concept is very simple, if you imagine two genes located in close proximity to one another on the chromosome. During recombination event(meiosis), these genes will likely to stay together, and we call them linked. A simple example is study of fly populations, where eye color is linked to shape of wings, because genes responsible for development of these phenotypes are located on the same chromosome not far from each other. Association studies usually refer to the experiments where researcher notes a phenotype difference between two groups of individuals and tries to find genes that are responsible for phenotype. For example, researcher would note that individuals in a group A have more heart attacks than in control group B. Association study would than focus on mapping the differences between two groups by looking at mutations present in group A and absent in group B. Hope this helps. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=iga.section.899 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=association+study+AND+cmed%5Bbook%5D+AND+16809%5Buid%5D&rid=cmed.section.5117 |
Subject:
Re: Difference between genetic linkage and association
From: svannes-ga on 30 Jan 2004 04:16 PST |
thanks. that's exactly what I was looking for. |
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