I am making nanoparticles for drug delivery by polymerizing N-butyl
cyano acrylate monomer. Once particles (100nm in diameter) are made, I
am coating
them with Tween 80 (a non-ionic surfactant) and Poly Ethyelene Glycol
(PEG) 20,000 by incuabtion in aquoes media. Now, what sort of chemical
bonding may I expect between 1)Polymer nanoparticles and Tween/PEG
overcoats and
2)Tween & PEG themselves?

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Clarification of Question by lifeofdeb-ga on 06 Apr 2004 18:16 PDT

(Tween 80 and PEG might form weak H bonding between each other which
is not of particular interest to my research. Let me know if you can
think of any other type of bonding)

Depends on conditions of incubation.  If you just put them in water
for a short perdiod of time, that is less than forever, then you can't
expect much besides hydrogen bonding + hydrophobic interactions
between long aliphatic chans. You may be underestimating the power of
hydrogen bonding in numbers: most of large biomolecules are held
together rather tightly by hydrogen bonding, and your ester
nanoparticles + olygomeric/polymeric alcohols Tween 80 and PEG sure
have many many possibilities for hydrogen bonding. In fact, these
hydrogen bonded agregates are going to be formed first.  Then, if you
add concentrated acid/base, you may promote reesterification to form
ester bonds between the polyacrylic acid and the polyalcohols.

And by the way, it's "n-butyl" not "N-butyl". "n-" means normal, and
"N-" means attached to a nitrogen. Makes a big difference :)