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Q: chemistry/biology ( Answered 5 out of 5 stars,   3 Comments )
Question  
Subject: chemistry/biology
Category: Science > Chemistry
Asked by: rusty-ga
List Price: $20.00
Posted: 25 Jun 2002 00:19 PDT
Expires: 25 Jul 2002 00:19 PDT
Question ID: 32776
Is rosehipseed oil the cure for wrinkles/preventing wrinkles/healing
scars and helping with skin blemishes.
I would like to know this from University paper research.
I would like evidence that supports rosehipseed oil contains Tretinoin
or vitA
Answer  
Subject: Re: chemistry/biology
Answered By: livioflores-ga on 29 Jun 2002 18:51 PDT
Rated:5 out of 5 stars
 
Hi rusty!!
I have researched for you the properties of the Rose Hip Seed Oil,
knowed in spanish as Rosa Mosqueta.

The plant's scientific name is Rosa Aff. Rubiginosa. Its flowers are
pink color and as the petals drop, the plant develops a colorful red
oval - shaped fruit.

Rose hip oil is obtained from the seeds of the Rosehip fruit. Rose Hip
Oil contains a very high level of essential polyunsaturated fatty
acids (EFAs), they are called " essential " because our body is not
able to reproduce them.

Several researches identified the presence of Trans-Retinoic acid that
is marked as Tretinoin.

Knowing that, follows to look for properties of the Tretinoin.
Tretinoin is the component responsible for the remarkable
pharmacological properties of Rosa Mosqueta. Trans-Retinoic acid is a
derivative of Retinol (Vitamin A) and it is used in Renova and Rentin
A formulation.
The tretinoin is one of the acids which are important to maintain a
healthy skin, for they are components of the cell's membrane and
precursors of prostaglandine/leucotriens (their activity is
hormone-like), providing tissue-regenerating and rejuvenating effects.

I found an article in the magazine Dermatology Times: "Review Study
Supports Tretinoin's Antiaging Effects : Scarcity of well-controlled
studies makes firm conclusions elusive, more so for AHA
products.(Brief Article)"
An important paragraph says:
"The tretinoin studies identified statistically significant benefits
for improving surface roughness, mottled hyperpigmentation, and fine
wrinkles. However, in the two well-designed AHA investigations,
benefit was minimal and limited only to improvement of the general
texture of facial skin compared with controls, probably reflecting AHA
exfoliative action and ability to increase skin moisture content.
Coarse wrinkling, yellowing, sallowness, and telangiectasias were
unresponsive to tretinoin and AHAs, reported Dr. Hornung, assistant
professor of dermatology, University of Washington School of Medicine,
Seattle."
View the full article at:
http://findarticles.com/cf_dls/m0UMR/4_21/61908815/p1/article.jhtml


You can find some information related to RENOVA (tretinoin emollient
cream 0.05%) at:
"Impact Health Care" 
"Renova Medical Information - Frequently Asked Questions"
http://www.impacthealthcare-md.com/renova-faq.html 

You can read here:
"...RENOVA is a rich emollient cream developed specifically for
treating fine lines and wrinkles...
...In clinical studies there is an enhanced production of collagen in
areas of treated skin...
...Researchers believe this is one way that RENOVA reduces the signs
of aging...
...
RENOVA TIMELINE:

1-2 months: you notice smoother skin and a softer texture to your skin

3-4 months: freckles and brown spots begin to fade. Fine lines and
wrinkles begin to diminish. A rosier glow to your skin is obtained

6 months: Benefits should be apparent with fewer wrinkles and smoother
and more even toned skin."


Also you can find some information related to RETIN A
"Impact Health Care" 
"Retin A Medical Information - Frequently Asked Questions"
http://www.impacthealthcare-md.com/retin-a-faq.html

You can read:
"The RETIN-A (tretinoin gel 0.1%) is proven to reduce the severity of
acne vulgaris in effected patients...RETIN-A can significantly reduce
the severity of these lesions."


There is an article titled "Pathophysiology of premature skin aging
induced by ultraviolet light" wich conclusions says:
"Multiple exposures to ultraviolet irradiation lead to sustained
elevations of matrix metalloproteinases that degrade skin collagen and
may contribute to photoaging. Treatment with topical tretinoin
inhibits irradiation-induced matrix metalloproteinases but not their
endogenous inhibitor."
Read the abstract and the full article at:
"The New England Journal of Medicine" website
http://content.nejm.org/
"Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light"
article
http://content.nejm.org/cgi/content/full/337/20/1419

For more articles related to Tretinoin is this site:(almost full
articles)
http://content.nejm.org/cgi/search?excludeflag=TWEEK_element&search_tab=articles&searchtitle=Articles&searchterm=tretinoin&sendit=GO&where=titleabstract&sortspec=PUBDATE_SORTDATE+desc+Score+desc&fmonth=Jan&fyear=1975&tmonth=Jun&tyear=2002&volume=&firstpage=


So dear Rusty the utility of the Tretinoin in the treatment of
wrinkles, aging and several types of skin damage is well demonstrated.
Adding this to the presence of tretinoin in the Rose Hip Seed Oil, we
can conclude that the use of it produces the benefits of Tretinoin,
but without secondary side effects, because the tretinoin contained in
it is in a natural state as part of a complex system of unsaturated
fatty acids. Therefore, its action is controlled and slowly released
by nature, eliminating the risk of overdoses.

And always remember: Rose Hip Seed Oil is for cosmetic use, but Renova
and Retin A are for medicine use.


For more professional articles check the following links:

"Journal of the American Academy of Dermatology"
http://www2.us.elsevierhealth.com/scripts/om.dll/serve?action=searchDB&searchdbfor=home&id=jd

Search Results for Tretinoin:
http://www2.us.elsevierhealth.com/scripts/om.dll/search?srch_radio_jour=srch_jour&srch_jour=jd&srch_radio_dates=srch_all_dates&action=searchft&srch_year_from=2002&srch_month_from=07&srch_year_to=2002&srch_month_to=07&srch_fields1=all&srch_value1=tretinoin&srch_logicop1=and&srch_fields2=all&srch_value2=&id=jd&special=


"MUHealth, University of Missouri Health Care"
http://www.muhealth.org/

Search Results for Tretinoin:
://www.google.com/u/muhealth?q=tretinoin&domains=missouri.edu&sitesearch=missouri.edu&q=muhealth


"Entrez-PubMed"
Search Results for Tretinoin:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&from_uid=1729619


Search Keywords:
With Google:

"Rose hip seed oil"
://www.google.com/search?q=%22rose+hip+seed+oil%22

"Rose hip seed oil" research
://www.google.com/search?hl=en&lr=&ie=ISO-8859-1&q=%22rose+hip+seed+oil%22+research


With Prebot:

Tretinoin
http://prebot.com/prebot.cgi?q=tretinoin&modlist=engweb&submit=Search

Tretinoin research
http://prebot.com/prebot.cgi?q=tretinoin+research&modlist=engweb&submit=Search



I hope you can find this answer usefull, and feel free to request a
clarification if you need it.

Regards
livioflores-ga
rusty-ga rated this answer:5 out of 5 stars
this has exeeded my expectations for an answer
thank you very much Livioflores!

Comments  
Subject: Re: chemistry/biology
From: pwi_pwii-ga on 25 Jun 2002 23:14 PDT
 
Hi Rusty:

By searching rose hip seed oil I found many sites that indicate that
rose hip seed oil contains Trans-Retinoic Acid(T retinoin, Tretinoin)
or Retine-A.  I continued my search using "Tretinoin university
research" and found a link to the University of Michigan School of
Dermatology.  One of their professors, I believe a Dr. Kang has had
many papers published on the subject.  Some of these are in the NEw
England Journal of Medicine.  Because I do not have a membership to
that publication I was not able to read the entire articles, however,
I was able to read a couple of the abstracts. I have provided links to
these abstracts.  They maybe too long to actually link, but you can
always type it in manually.

It appears that tretinoin does in fact help with skin blemishes
related to pigmentation and sun damage.  If you were to continue in
the journal you may also find reults on wrinkling etc.

http://content.nejm.org/cgi/content/abstract/337/20/1419?
http://content.nejm.org/cgi/content/abstract/326/6/368?

Good luck
Pwipwii
Subject: Re: chemistry/biology
From: pwi_pwii-ga on 25 Jun 2002 23:16 PDT
 
P.S. I shortened the addresses with only what was necessary to get you
where you needed to go.
Subject: Re: chemistry/biology
From: rusty-ga on 26 Jun 2002 00:13 PDT
 
pwii - great answer thanks
first answer was from sites I found easily enough myself.
thankyou both though.

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