Hello heinrich-ga,
Please note that I am simply passing on information that is in the
public domain, and not attempting to provide you with medical advice.
Surgery to correct the curvature is normally seen as a last resort if
medication fails. Other established approaches include to decrease
symptoms include "radiation therapy or corticosteroid injections into
the fibrous band of tissue. Topical verapamil, an oral medication used
for high blood pressure, has recently been shown to improve the
disease and has been approved for use in treating Peyronie’s."
This is from the patient information at the US National Library of
Medicine
http://www.nlm.nih.gov/medlineplus/ency/article/001278.htm
Looking into the medical journal literature, I found that most
articles dealt with surgical approaches. However, I also found the
following articles dealing with other types of therapy, which have
been published in the last two years. Please remember that these are
new approaches which may not yet have found their way into the
treatment regimens of all medical centres.
1. Extracorporeal shock wave treatment for Peyronies disease using
EDAP LT-02; preliminary results
Hiroshi Kiyota, Yukihiko Ohishi, Koji Asano, Norio Hasegawa, Jun
Madarame, Kenta Miki, Nobuki Kato, Takahiro Kimura, Takehito Ishiyama,
Shigetaka Maeda, Tatsuya Shimomura, Yutaka Shiono and Jun Miki
International Journal of Urology
Volume 9 Issue 2 Page 110 - February 2002
All 4 evaluable patients treated in this way experienced total relief
from pain, but there was no improvement in curvature.
http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1442-2042.2002.00430.x&abbrev=Int%20J%20Urol&vol=9&page=110&goto=abstract
2. BJU International, Volume 89 Issue 9 Page 895 - June 2002
Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of
advanced and resistant Peyronie's disease
G. Cavallini, G. Biagiotti, A. Koverech* and G. Vitali
Propionyl-l-carnitine plus verapamil significantly reduced curvature,
plaque size, the need for surgery and disease progression. The
authors concluded that this is the treatment of choice for advanced
and resistant Peyronie's disease.
http://www.blackwell-synergy.com/rd.asp?abbrev=BJU%20Int&vol=89&page=895&goto=abstract
3. Eur Urol 2001 Sep;40(3):343-8
Pilot study on liposomal recombinant human superoxide dismutase for
the treatment of Peyronie's disease.
Riedl CR, Plas E, Vorauer K, Vcelar B, Wagner A, Pfluger H.
Department of Urology and Ludwig Boltzmann Institute of Andrology,
Municipal Hospital Lainz, Vienna, Austria.
"The present results suggest that liposomal recombinant human
superoxide dismutase gel is a promising treatment for patients with
early stage Peyronie's disease. Early institution of lrhSOD therapy
may prevent disease progression. The present preliminary results are
the basis of a placebo-controlled randomized study." The gel
eliminated pain and restored function in a majority of patients.
4. The Use of Betamethasone and Hyaluronidase Injections in the
Treatment of Peyronie's Disease
Athanasios Lamprakopoulos; Ioannis Zorzos; Michael Lykourinas
Scandinavian Journal of Urology and Nephrology Volume: 34 Number: 6
Page: p355 -- p360
"The method is safe, well tolerated by patients and characterized by a
high response rate in patients with a history of less than 12 months
and a plaque not exceeding 20 mm."
5. Int J Impot Res 2000 Jun;12(3):169-75
Treatment of Peyronie's disease with oral colchicine: long-term
results and predictive parameters of successful outcome.
Kadioglu A, Tefekli A, Koksal T, Usta M, Erol H.
"systemic oral agents, such as colchicine, may be preferred in the
early phase of the disease."
Search strategy: "Peyronie's disease" on Google and also on Medline at
http://www.nlm.nih.gov/ In addition, patient information was obtained
from the Medline Plus facility on the NLM site
I hope this is useful
tehuti |
