I want to find information on prescribing guidlines for
Thiaglidizones, and just what "thiaglidizones" are, and do.

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Request for Question Clarification by livioflores-ga on 17 Apr 2004 08:38 PDT

Are you sure about the spelling, I am unable to find any reference for
Thiaglidizones.

Thank you.

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Clarification of Question by dimensionx-ga on 17 Apr 2004 09:38 PDT

As far as I know, the spelling is correct, and I believe this is a new
medicine for the treatment of diabetes. I wonder if there is any info
out there on what it does, or if it is somehow related to
Thiazolidinediones (TZD's)... a drug that combats type 2 diabetes by
acting as an insulin sensitizer.

Hi dimensionx,

I believe you are referring to * troglitazone * ,(brand name
?Rezulin?) now off the market for causing liver problems.
 http://www.diabetesmonitor.com/rezulin.htm
http://www.opolaw.com/defective-drugs/rezulin/

I believe you are referring to pioglitazone, a newer insulin
sensitizer, (decreases insulin resistance) ,sold under the brand name
?Actos?, and is manufactured by Takeda Pharmaceuticals America, Inc.
and Eli Lilly. This ?replacement? drug has been approved by the FDA.
http://www.rxlist.com/cgi/generic2/pioglit.htm
http://www.diabetesmonitor.com/actos.htm

?The dose of ACTOS should not exceed 45 mg once daily in monotherapy
or in combination with sulfonylurea, metformin, or insulin?
http://www.rxlist.com/cgi/generic2/pioglit_ids.htm

Health Professional?s Data Sheet for Actos, including class of action
and dosing information:
http://www.medsafe.govt.nz/Profs/Datasheet/a/Actostab.htm

If any part of this answer is unclear, please request an Answer
Clarification, *before rating*, as this will enable me to asist you
further, if possible.

Regards,
crabcakes

I agree with my colleague, Senorita Crabcakes, that this is a class of
antidiabetic drugs, thiazolidinediones (TZDs).  There are a few
corrupted spellings for this drug class on Google, however, which
might be confusing.  I also checked
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi and there were no
citations for this word, which is a solid indicator that it's a wrong
spelling.

Here's a bit of additional information that I hope is useful:

Thiazolidinediones

One of several different classes of pills that lower the level of
glucose in the blood. Used in Type 2 diabetes. There are several
thiazolidinedione pills available. This class of medications is also
called "glitazones."

Each type of pill is sold under two names: one is the generic name as
listed by the US Food and Drug Administration; the other is the trade
name given by the manufacturer. The thiazolidinediones that are
presently available are:

Generic Name: rosiglitazone
Trade Name: Avandia

Generic Name: pioglitazone
Trade Name: Actos

http://www.childrenwithdiabetes.com/dictionary/t.htm
http://www.blackwell-synergy.com/links/doi/10.1046/j.1464-5491.1999.00023.x/abs
http://www.thedoctorwillseeyounow.com/articles/diabetes/drugs_2

****************

There is also a safety alert on TZDs, so if you're looking for a
possible heart failure/TZD connection, you might check here:
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256E63002D81E9
http://www.lifescan.com/care/news/dn120903-2

****************

And there's also a next generation drug class called an
arylthiazolidinedione (TZD-18):

"New research suggests that PPAR agonists may have potential in 
proliferative disorders.  (...) Merck & Co will present data on its 
dual PPAR alpha/gamma agonist, TZD-18, against human glioblastoma cell 
lines.
http://thomsoncurrentdrugs.com/press/2004/8219160
http://www.thefutureforum.com/clinicdata/newsitem.asp?ReleaseID=547
http://www.wissenschaft-online.de/gbm/mosbach04/homepage/abstract_detail.php?artikel_id=462

*****************

DM-2 trials on K-111
http://www.stronghealth.com/clinical_trials/trial_details.cfm?trialid=502&id=48
http://www.d4pro.com/HomeDefault.asp
http://www.d4pro.com/News/Items/Research_Editorial_2004_01.asp

******************

Also if try "second generation" "TZD" "Metaglip" on Google there's a
PDF document available, but unauthorized reproduction is prohibited
and I cannot post it here.  It does, however, give the comparative
dosages for most antidiabetic meds.

With the diabetes epidemic, there is very aggressive research being
done in this area and it's tough to stay current on all the
information available.  I happen to work in the medical field, so I'd
be doing this research eventually.  I'm happy to pop it in if you or
anyone reading is able to use any of it.

Best wishes and good health to you,
V