Went to medline use ("hepatitis C" OR HCV) AND ("growth hormone" OR
GH)
Brief answer: NO
The articles found measured GH levels of patients on interferon-
the GH levels were increased as were cortisol and other stress
hormones.
The higher GH levels may then cause "insulin resistance" (reducing the
effectiveness of insulin in maintaining glucose homeostasis).
Here is a link to a full-text article:
http://jcem.endojournals.org/cgi/content/full/83/10/3681
Change of peripheral levels of pituitary hormones and cytokines after
injection
of interferon (IFN)-beta in patients with chronic hepatitis C.
J Clin Endocrinol Metab. 1998 Oct;83(10):3681-7.
PMID: 9768684 [PubMed - indexed for MEDLINE]
2: Imano E, Kanda T, Ishigami Y, Kubota M, Ikeda M, Matsuhisa M,
Kawamori R,
Yamasaki Y.
Interferon induces insulin resistance in patients with chronic active
hepatitis
C.
J Hepatol. 1998 Feb;28(2):189-93.
PMID: 9514530 [PubMed - indexed for MEDLINE]
3: Muller H, Hiemke C, Hammes E, Hess G.
Sub-acute effects of interferon-alpha 2 on adrenocorticotrophic
hormone,
cortisol, growth hormone and prolactin in humans.
Psychoneuroendocrinology. 1992 Oct;17(5):459-65.
PMID: 1336606 [PubMed - indexed for MEDLINE]
4: Bonora E, Orioli S, Coscelli C, Buzzelli G, Gentilini P, Butturini
U.
Possible roles of insulin, glucagon, growth hormone and free fatty
acids in the
pathogenesis of insulin resistance of subjects with chronic liver
diseases.
Acta Diabetol Lat. 1984 Jul-Sep;21(3):241-50.
PMID: 6393673 [PubMed - indexed for MEDLINE]
This paper examined the effects of GH on adult with chronic liver
disease (CLD)
J Clin Endocrinol Metab 2002 Jun;87(6):2751-9
GH treatment in adults with chronic liver disease: a randomized,
double-blind,
placebo-controlled, cross-over study.
Wallace JD, Abbott-Johnson WJ, Crawford DH, Barnard R, Potter JM,
Cuneo RC.
Metabolic Research Unit, Department of Medicine, University of
Queensland,
Princess Alexandra Hospital, Wooloongabba, Brisbane 4102, Australia.
jwallace@medicine.pa.uq.edu.au
They found:
Clinical side effects included worsening edema and ascites.
Hepatocellular function did not change. Therefore, rhGH treatment in
CLD: 1) overcame hepatic GH resistance; 2) may have improved
whole-body protein catabolism; 3) increased lipolysis and lipid
oxidation; 4) increased insulin resistance; and 5) had potent
antinatriuretic effects. Long-term safety and efficacy require further
assessment.
Found some more references:
Here: the authors found Hepatitis C virus activates the IGF-II
(insulin-like growth factor II gene), GH does this as well. IGF-II
has been associated with liver carcinogenesis.
J Endocrinol 2002 Mar;172(3):457-65
GH is a regulator of IGF2 promoter-specific transcription in human
liver.
von Horn H, Ekstrom C, Ellis E, Olivecrona H, Einarsson C, Tally M,
Ekstrom TJ.
Department of Clinical Neuroscience, Experimental Alcohol and Drug
Addiction
Research Section, Karolinska Hospital, L8:01, S-171 76 Stockholm,
Sweden.
Virology 2001 May 10;283(2):167-77
Hepatitis C virus core protein transactivates insulin-like growth
factor II gene
transcription through acting concurrently on Egr1 and Sp1 sites.
Lee S, Park U, Lee YI. |