I would like to know the latest results from medical research into 3
areas of Parkinson Disease.
First, but 2nd in importance to me personally, what are the most
promising avenues toward a cure for people diagnoses to have PD?
Secondly, and of prime interest to me, what is coming along in the
area of controlling or retarding the debilitating symptoms of PD once
it has been diagnosed and the disease has progressed for a few years?
This would include such things as tremors and dementia. To my
knowledge, L-Dopa or, "Requip", (One of its Marketing trademarks) is
the only helpful drug at present, as well as forms of cryogenic
surgery. I have not heard of anything that actually turns PD back to
an earlier stage, even temporarily much as radiation can turn around
Cancer temporarily if not cure it. I guess this is potentially a 2
part question. Thirdly, and of a lesser emphasis to me, but not to be
ignored is research toward a true cure and eventual prevention; since
basic research in the curative and preventive areas can also lead to
discoveries or new directions of research for controlling PD before
curing it.
If you agree, I would like to confine these 3 responses to those
drugs, devices or surgical techniques that have undergone are least
one successful clinical trial or were uncovered in a large
epidemiological study as a minimum for consideration here. I have gone
over most of the true "Lay" research information available at the
large self-financed PD sites, (not in depth though yet), such as Mr.
Mike Fox's. I would like research that might focus on journals,
research papers, even dissertations and other unpublished or just
journalistically reported findings that would be difficult to
prioritize with normal search engine spiders? output.
I am not looking for a large number of citations necessarily. I am
more interested in Quality and the availability of linking or perhaps,
best of all, your pointing me in the right direction so that I can
continue the research to the depth that my level of medical knowledge
will allow me to delve. Maybe what I am at least partially looking for
would be help in identifying directories in the so called "invisible
web" that might be difficult for me to find on my own, especially
those of quality and legitimate potential for my further research. I
guess I am looking for a research mentor?s guidance, if you are
willing, as much as only pure research citations, although I do want
the cream of the crop of the latter.
I apologize ahead of time for one of my many short comings ?
verbosity. I hope you will view it as a net plus rather than a
hindrance. Above all, I do not want the researcher I work with to
think that I thus have an unspoken expectation of an overly deep and
lengthy product to be delivered for me to be satisfied. |
Clarification of Question by
chadbourne-ga
on
23 Apr 2004 16:27 PDT
When I stated that I needed some mentoring help, I was trying to be
more descriptive of the type of response I was looking for. I was not
suggesting a short reply for this price range, followed by a lot of
clarification as being the research method I wanted used.
I only wanted to emphasize that, in part, I would appreciate some
guidance into the "invisible Web" and other productive access points
that would be on target, but with too many directories with too many
entries for you to screen before passing the information along to me.
So deemphasize the primary importance I gave to Quality in my primary
question, and instead give me a normal quantity of results according
to price and the rest of my criteria and your best judgment for
inclusion and leave it for me to subjectively analyze your answers and
to go more deeply as I personally judge appropriate.
If this clarifies better what I am looking for, you can expect only a
normal number of clarifying questions, not a mentor's hand holding
every step of the way. I was speaking figuratively to aid in
describing in more depth the type of response of which my abilities
could make best use.
|
Request for Question Clarification by
hummer-ga
on
23 Apr 2004 16:41 PDT
Hi chadbourne,
I believe BioMedNet (bmn.com) would be an excellent resource for you,
but I was unhappy to read that they will be ending the service: "The
BioMedNet News & Features archive and all other BioMedNet services,
will remain accessible until June 2004." BioMedNet certainly satisfies
your need for, "... journals, research papers, even dissertations and
other unpublished or just journalistically reported findings that
would be difficult to
prioritize with normal search engine spiders? output.", if you're up
for reading hundreds of Abstracts and then ordering any that you'd
like to read in its entirety. It is a gold mine of medical information
from all over the world, not just linear in design, but it is all
"meshed" so that you can easily find related articles. It is free to
sign up for, and with that you get to read the Abstracts and order a
copy of the full article if you want to (mailed or faxed). Here are
four examples (without the Abstracts):
Title: Maintaining the square. How older adults with Parkinson's
disease sustain quality in their lives.
Author(s): Whitney CM
Journal: J Gerontol Nurs
ISSN: 0098-9134
Volume: 30
Issue: 1
Pub Year: 2004
Pages: 28-35
Publisher's copyright fee* £1.41
Post (First Class or Air Mail) £7.50
Title: New drugs in the future treatment of Parkinson's disease.
Author(s): Djaldetti R, Melamed E
Journal: J Neurol
ISSN: 0340-5354
Volume: 249 Suppl 2
Issue:
Pub Year: 2002
Pages: II30-5
Publisher's copyright fee* £18.92
Post (First Class or Air Mail) £7.50
Title: [A prospect of treatment for Parkinson's disease in the 21st century]
Author(s): Yanagisawa N
Journal: Nippon Rinsho
ISSN: 0047-1852
Volume: 58
Issue: 10
Pub Year: 2000
Pages: 1968-74
Publisher's copyright fee* £5.00
Post (First Class or Air Mail) £7.50
Title: Use of gene therapy in central nervous system repair.
Author(s): Tinsley R, Eriksson P
Journal: Acta Neurol Scand
ISSN: 0001-6314
Volume: 109
Issue: 1
Publication Year: 2004
Pages: 1-8
Publisher's copyright fee* £15.00
Post (First Class or Air Mail) £7.50
For 2004 alone, there are 563 articles listed (for 2003-4, there are
2572 articles), searching for "Parkinson's Disease". There is an
Advanced Search, for making refinements, such as "from and to" dates,
and adding words such as, drugs, or cure. These articles are from
medical journals, so you do need some knowledge of the terminology -
they are not designed for the general public.
Please have a look at the website (while it is still there!), and see
if it is what you are looking for (you'll have to sign up first). Take
your time and look around at everything - there is alot there.
Afterwards, let me know what you think - perhaps it's more than you
have in mind, or too expensive, or perhaps you'll find it of interest
but not worth the $100 you offered (especially since you'd have to pay
for the articles!).
Take your time,
hummer
(p.s. I got this ready before I saw your clarification)
|
Clarification of Question by
chadbourne-ga
on
23 Apr 2004 23:40 PDT
Hi Hummer!
Excellent site, correct direction. Especially look into FTP sites and
other spider evasive sites, some of the best sites for me may
themselves be compilations, summaries or syntheses of the best works
in a particular direction. I would be quite happy if you identified
research already done, as well as original work of your own as you see
fit. Please write me to clarify all I have thrown at you up to now.
Beers regards,
Chadbourne
|
Request for Question Clarification by
hummer-ga
on
24 Apr 2004 08:07 PDT
Hi chadbourne,
Well, I think it is time to show you the direction my research has
taken me - please redirect as needed. First, though, I came across
this interesting idea that you may be interested in trying out.
BIOMED TOOLBAR
"Similar in concept to the Google toolbar, but designed for
scientists, the BioMed Central toolbar allows you to conveniently
search BioMed Central, PubMed Central, PubMed, Faculty of 1000 and
Google."
http://www.biomedcentral.com/info/about/toolbar
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>> TREATMENTS
"Secondly, and of prime interest to me, what is coming along in the
area of controlling or retarding the debilitating symptoms of PD once
it has been diagnosed and the disease has progressed for a few years?"
->PHARMACOLOGIC TREATMENTS
Parkinson?s disease drug treatment glossary
http://www.parkinsonsdisease.com/lwp/dt_gloss.htm
Drug Therapy in Managing the Effects of Parkinson's Disease
http://www.parkinsonsinfo.com/about_parkinsons/drugtherapy.html
Pharmacologic Treatments
* Levodopa
* COMT Inhibitors
* Dopamine Agonists
* Dopamine Receptors and Dopamine Agonists
* Tables of Therapeutic Responses and Side Effects
* Selegiline, Amantadine, Anticholinergics, and Other Drugs
http://www.wemove.org/par/par_phm.html
APOKYN: Mylan Announces FDA Approval of APOKYN? NDA
http://www.pdf.org/News/news.cfm?selectedItem=156&type=1&returnURL=news%2Ecfm%3Ftype%3D1
BROMOCRIPTINE: Bromocriptine versus levodopa in early Parkinson's disease
http://www.cochrane.org/cochrane/revabstr/AB002258.htm
CLOZAPINE: Clozapine Effective For Controlling Dyskinesias In People
With Severe Parkinson's
http://www.pdf.org/News/news.cfm?selectedItem=145&type=2&returnURL=news%2Ecfm%3Ftype%3D2
COENZYME: Effects of Coenzyme Q10 in Early PD: Evidence of Slowing of
the Functional Decline
http://www.parkinson.org/newscoq10.htmKinetra® Neurostimulator /
Access® Therapy Controller
MIRAPEX: SPECT Imaging Assesses the Effects of Mirapex on Slowing the
Progression of Parkinson's Disease
http://www.parkinson.org/spectmir.htm
RASAGILINE: Parkinson?s Drug with Less Side Effects
http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=8507&channelid=CHAN-100013
ROPINIROLE: Slower progression in Early Parkinson's Disease Treated
with Ropinirole Compared with L-Dopa
http://www.parkinson.org/slowpropd.htm
->NONPHARMACOLOGIC TREATMENTS
Nonpharmacologic Treatments
http://www.wemove.org/par/par_nphm.html
->SURGICAL TREATMENTS
Surgical Treatments:
Three types of surgery are currently used for the treatment of Parkinson's disease:
* Pallidotomy
* Thalamotomy
* Deep Brain Stimulation
A fourth procedure, Fetal Nigral Cell Transplantation, is an
experimental procedure still under development.
http://www.wemove.org/par/par_sur.html
Pallidotomy for Parkinson's Disease
http://nyneurosurgery.org/park_treat.htm
Subthalamic Stimulation for Parkinson's Disease
http://www.medical-journals.com/r031113a.htm
>>>>>>>>>>>>>>>>> PROMISING AVENUES
"First, but 2nd in importance to me personally, what are the most
promising avenues toward a cure for people diagnoses to have PD?"
FDA Approves Two New Devices for Deep Brain Stimulation
http://www.pdf.org/News/news.cfm?selectedItem=141&type=1&returnURL=news%2Ecfm%3Ftype%3D1
NICOTINE: Nicotine Rescues Brain Cells
http://www.pdf.org/News/news.cfm?selectedItem=151&type=1&returnURL=news%2Ecfm%3Ftype%3D1
ZINC/COPPER: Chemical Mixture of Zinc, Copper Helpful In Alzheimer?s
Disease, Also Likely In Parkinson?s
http://www.pdf.org/News/news.cfm?selectedItem=149&type=1&returnURL=news%2Ecfm%3Ftype%3D1
WLDS: A New Protective Protein Against Parkinson's
http://www.pdf.org/News/news.cfm?selectedItem=148&type=1&returnURL=news%2Ecfm%3Ftype%3D1
DbHB: Epilepsy drug may offer a cheap and easy way to treat PD
http://www.pdf.org/News/news.cfm?selectedItem=120&type=1&returnURL=news%2Ecfm%3Fyear%3D2003%26type%3D1
"Researchers studying the Hedgehog signaling pathway have identified
small molecules that could form the foundations of exciting new
treatments for Parkinson's disease and certain cancers."
http://www.biomedcentral.com/info/about/pr-releases?pr=20021108
Current Clinical Trials
http://www.clinicaltrials.gov/ct/gui/action/SearchAction;jsessionid=8371110739E154E2E576B46812418493?term=Parkinson%27s+Disease
>>>>>>>>>>>>>>>>>> RESEARCH
"Thirdly, and of a lesser emphasis to me, but not to be ignored is
research toward a true cure and eventual prevention; since basic
research in the curative and preventive areas can also lead to
discoveries or new directions of research for controlling PD before
curing it."
STEM CELLS: Parkinson's Disease Foundation Hails New Korean Stem Cell
Study Involving Embryonic Stem Cells
http://www.pdf.org/News/news.cfm?selectedItem=144&type=1&returnURL=news%2Ecfm%3Ftype%3D1
Stem Cell Research
http://www.nlm.nih.gov/medlineplus/ency/article/007120.htm
Cloning Cures Parkinson's -- in Mice
http://my.webmd.com/content/Article/74/89137.htm?printing=true
>>>>>>>>>>>>>>>>> GENERAL RESOURCES
PubMed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
MedFetch
http://www.medfetch.com/
Medline
http://www.docguide.com/news/content.nsf/PatientResAllCateg/Parkinson's%20Disease?OpenDocument#Disease
NPF Library
http://www.parkinson.org/toread.htm
NeuroScience-Net
http://www.neuroscience.com/
Neuroscience Links:
http://neuro.med.cornell.edu/
Parkinson's Disease Specific Interest Group
http://www.ex.ac.uk/library/eml/park.html
>>>>>>>>>>>>>>>> FORUM
BrainTalk Community (old read only forum)
http://neuro-mancer.mgh.harvard.edu/cgi-bin/forumdisplay.cgi?action=topics&forum=Parkinson%27s+Disease&number=71&DaysPrune=1000&SUBMIT=Go
>>>>>>>>>>>>>>>>>
Additional Links
Re-Wired for Life
http://www.rewiredforlife.org/
The Bachmann-Strauss Dystonia & Parkinson Foundation
http://www.dystonia-parkinsons.org/
Young Parkinson's Information and Referral Center
http://members.aol.com/apdaypd/young/
World Parkinson Disease Association (WPDA)
http://www.wpda.org/
Parkinsons New Zealand
http://www.parkinsons.org.nz/
The Parkinson's Disease Society
http://www.parkinsons.org.uk/
The American Academy of Neurology
http://www.aan.com/professionals/
Awakenings
http://www.parkinsonsdisease.com/
The Parkinson Foundation of Canada
http://www.parkinson.ca/home.html
The Parkinson's Institute
http://www.parkinsonsinstitute.org/
American Parkinson's Disease Association
www.apdaparkinson.com
National Institute of Neurological Disorders and Stroke
www.ninds.nih.gov
National Parkinson Foundation Inc.
www.parkinson.org
I'm off to take a break while I wait to hear back from you -
hummer
|
Clarification of Question by
chadbourne-ga
on
26 Apr 2004 14:30 PDT
Hi Hummer!
I was away this weekend, so I wanted to at least touch base with you
since I have perused quickly your dual research submission. You are
very much on the right track and I am very satisfied to date. However,
other than any general recent articles that may come in on alerts you
probably have, hold off for now on any more work, as I want to save
the rest of your allocated time to me for specific and most likely
precise clarifications. In advance, I will advise you that this will
be confined mostly to the area of arresting further damaging progress
of it or, more hopefully for present sufferers, pushing back the
symptom manifestation of the disease to be less burdensome, even if
the underlying neurological damage already done by PD can not be
reversed; much as say "Requip" given to a newly diagnosed patient
improves the quality of life by offsetting losses of the brain to PD
and somewhat slows its progress, even if only a perception
modification that helps toleration.
I will be in touch by the end of the week.
Warm regards,
Chadbourne
|
Request for Question Clarification by
hummer-ga
on
26 Apr 2004 15:02 PDT
Dear Chadbourne,
Thank you for the clarification and bringing me up-to-date. That's
fine, I'll look forward to your next post and try my best to provide
you with the most relevant information that's available. Remember,
don't be afraid of posting too many clarifications - you can't.
See you later,
hummer
|
