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Subject:
Gabapentin for Chronic Pain
Category: Health > Medicine Asked by: renoir-ga List Price: $15.00 |
Posted:
27 Jun 2002 19:33 PDT
Expires: 27 Jul 2002 19:33 PDT Question ID: 34364 |
I take 3000mg/day of Gabapentin for chronic pain from peripheral neuropathy (i.e. not seizure disorder). This is a very large dose. What significant side effects are there at this high dosage, aside from somnolence? What can I do to monitor, alleviate or prevent side effects? Any blood or urine tests to monitor usage? If I have surgery is this high dosage a problem? |
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Subject:
Re: Gabapentin for Chronic Pain
Answered By: richard-ga on 27 Jun 2002 20:32 PDT Rated: |
Hello and thank you for your question: The good news is that studies do show Gabapentin as effective against neuropathic pain, and it's side effects generally are not serious: "A recent article in the Southern Medical Journal discusses anecdotal evidence that antiseizure drugs provide the best relief for neuropathic pain, associated with nerve problems. The newest and most successful has been gabapentin, which seems to relieve a wide range of nerve pain, including that often accompanying cancer and aids. Better yet, this class of drugs has a low level of side effects. Drowsiness, dizziness, nausea and unsteadiness, if they do occur, can usually be alleviated by adjusting the dosages of the drug, while more severe side effects, such as liver toxicity, blood disorders and disturbed vision, are relatively rare." Time Magazine--Your Health--October 11, 1999 http://tinyurl.com/i4s This excerpt also implies that you probably do not need blood or liver tests to monitor the drug, as long as you remain alert to drowsiness, dizziness, etc. These are not the only side effects that you'll find mentioned on the warning label. Of the following cautions about Gabapentin (Neurontin) that I found on the Medline information site, it seems that the most serious likely risk is loss of balance and eye control, so you shouldn't drive or operate machinery while taking it. Here are the cautions, organized according to how dangerous they are to your health, and also by how likely you are to encounter the effects: -More Common Side Effects Requiring Medical Attention- "Clumsiness or unsteadiness; continuous, uncontrolled, back-and-forth and/or rolling eye movements" -Less Common Side Effects Requiring Medical Attention- "Depression, irritability, or other mood or mental changes; loss of memory" -Rare Side Effects Requiring Medical Attention- "Cough or hoarseness; fever or chills; lower back or side pain; painful or difficult urination" -Symptoms of overdose- "Diarrhea; double vision; drowsiness; sluggishness; slurred speech" -Other Side Effects That Usually Do Not Need Medical Attention- More Common "Blurred or double vision; dizziness; drowsiness; muscle ache or pain; swelling of hands, feet, or lower legs; trembling or shaking; unusual tiredness or weakness" Less common "Back pain; constipation; decrease in sexual desire or ability; diarrhea; dryness of mouth or throat; frequent urination; headache; indigestion; low blood pressure; nausea; noise in ears; runny nose; slurred speech; trouble in sleeping; trouble in thinking; twitching; vomiting; weakness or loss of strength; weight gain" [Side Effects of Gabapentin] http://www.nlm.nih.gov/medlineplus/druginfo/gabapentinsystemic202732.html#SXX18 You are right about 3,000 mg being a high dosage. One site cautions that if 600 mg fails to relieve pain, the drug should be discontinued altogether. University Center for Pain Medicine and Rehabilitation at Memorial/Hermann http://www.uth.tmc.edu/pain/pl-gaba.html But pain.com suggests dosages up to 2,400 mg daily for treatment of migraine. Pain.com http://www.pain.com/freecme/damtm_migraine/damtm_s23.cfm And dosages of even 5,000 mg are not unheard of: "The total daily dose of gabapentin may be as high as 5,000 mg if lower doses are not beneficial. Using this protocol, most patients are dramatically improved in one or two office visits." New Patient Treatment Protocol http://www.drjgoldstein.com/methodology/protocol.html So even if you do persist in taking the medication at your current dosage level, it seems that blood and liver function tests are not specifically recommended. Of course, you and your doctor may come to a different conclusion. Anther useful link: The Pains Of Trigeminal Neuralgia (This article also mentions surgery, so apparently the drug is not inconsistent with a surgical procedure) http://www.personalmd.com/news/trigeminalneuralgia_1211000.shtml Search Terms Used: Gabapentin pain liver blood Gabapentin pain dosage Neurontin "blood test" Gabapentin pain dosage Although I am not a doctor (and you should certainly not rely on this answer in formulating your treatment plan), I hope you find this information useful and responsive to your question. If you need anything further, I would appreciate your making a request for clarification before you rate my answer. Your friend richard-ga |
renoir-ga
rated this answer:
Dear Richard: Thanks for your thorough research. Very helpful and extremely rapid reply. renoir-ga |
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Subject:
Re: Gabapentin for Chronic Pain
From: duckymb-ga on 27 Jun 2002 21:02 PDT |
This question has been addressed very well, but I thought I'd add what I've found about the dosage: "Antiepileptics are also helpful in the treatment of neuropathic pain.15 Carbamazepine (Tegretol) has a well established efficacy in the management of trigeminal neuralgia, and case reports show a positive effect on neuropathic pain.16 The most effective antiepileptic medication, gabapentin (Neurontin), has demonstrated efficacy in reducing pain from moderate to mild in patients with diabetic neuropathy (900 to 3,600 mg three times a day)17 and in postherpetic neuralgia (2,400 to 3,600 mg three times a day).18 Patients should expect to experience benefit from a daily dosage of 1,800 mg of gabapentin. If this dose has no effect on the pain, a higher dose will generally not be helpful. If some relief is experienced at this dose, a higher dose may further improve pain relief. Lamotrigine (Lamictal) has been reported to reduce neuropathic pain in case reports, but controlled studies are not yet available.19" source: Treatment of Nonmalignant Chronic Pain http://www.aafp.org/afp/20000301/1331.html You didn't say how long you've been on this med, but side effects tend to be dose-related and usually subside within 8 weeks of treatment or increment. There is something I recall reading about Neurontin a while back and I'm not able to find the reference, but it relates to your high dosage. Something about the bioavailability of the drug and the incremental dosage...something to the effect that if you double a dose from 300 to 600, the bioavailability doesn't double and that the bioavailable dose may be considerably less than the 600, yet slightly more than the 300. I will continue to find this reference material. You can read the patient FAQ on Gabapentin (Neurontin) at rxlist.com http://www.rxlist.com/frame/display.cgi?drug=NEURONTIN You can read about warnings on Neurontin, including blood level monitoring information at rxlist.com http://www.rxlist.com/cgi/generic/gabapent_wcp.htm You can get information and feedback from others who have used this med for chronic pain at this fibromyalgia support medical forum: http://fibrohugsforums.mysitemain.com/cgi-bin/webbbs/fms/index.pl? Hope this helps DuckyMB |
Subject:
Re: Gabapentin for Chronic Pain
From: duckymb-ga on 27 Jun 2002 21:26 PDT |
Okay, I found some info on the bioavailability and high dosage issue. "saturable absorption (ca. 60% bioavailable, normally, but can decrease to 24% with large doses or use of antacids)" source: http://131.183.68.170/3720/3720_6.html From the FDA website: "A 400-mg dose, for example, is about 25% less bioavailable than..." www.fda.gov/ohrms/dockets/dailys/ 00/Jul00/072100/cp00001.pdf From Pfizer: "Gabapentin bioavailability is not dose proportional..." www.pfizer.com/hml/pi's/neurontinpi.pdf By the way, one of the side effects of this med is possible weight gain. If this is a great concern to you, there are other meds like Topomax which might be helpful that you might want to discuss with your medical team. Happy reading! DuckyMB |
Subject:
Re: Gabapentin for Chronic Pain
From: renoir-ga on 27 Jun 2002 22:38 PDT |
Info for other chronic pain readers: Prior to taking the high dose of Gabapentin my MD suggested Trileptal. I discontinued this after only 3 days, due to terrible headaches. I located the mfgrs. report on the clinical trials for this drug and per their own data, 20 PERCENT of the patients in the clinical trial stopped Trileptal due to headache. I then tried Carbatrol (extended release Tegretol). it is more effective than the Gabapentin and much, much cheaper. But this too caused headaches and I had to discontinue that also. My MD tells me that he has 60-70 patients on Carbatrol and they don't have headaches. One lesson from all this is that everyone has a unique physico-chemical system, and some experimentation is necessary when dealing with chronic pain. renoir-ga |
Subject:
Re: Gabapentin for Chronic Pain
From: voila-ga on 28 Jun 2002 12:01 PDT |
As an FYI, Pfizer recently was granted approval by the FDA to market Gabapentin for treatment of post-herpetic neuralgia. Here is a link (via make a shorter link redriction) and additional information on neuropathic pain. http://makeashorterlink.com/?S62753821 http://makeashorterlink.com/?M46721821 Regards, V |
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