Completely off the wall here, and only very limited understanding, but
I found a couple of references to the term 'ASD4' that *may* link to
colitis indirectly.
Title
ASD4, a new GATA factor of Neurospora crassa, displays
sequence-specific DNA binding and functions in ascus and ascospore
development.
Source
Biochemistry. 39(36):11065-73, 2000 Sep 12.
This abstract talks about something called 'ASD4' being a specific
GATA binding protien.
Now, cross checking for GATA and Colitis gave up this...
Title
Peroxisome proliferator-activated receptor gamma agonist ligands
stimulate a Th2 cytokine response and prevent acute colitis.
Source
Inflammatory Bowel Diseases. 8(5):330-9, 2002 Sep.
which has nothing at all to do with ASD4, but does suggest that these
ligands 'stimulated increased GATA-3 expression' in mice, and GATA-3
is a protien that binds GATA sequences, and in doing so may modify the
immune system in mice.
Putting it all (very shakily I might add) together, it may be that
someone has come up with the idea of using the ASD4 protien to try and
illicit the same kind of response.
At the very least there would appear to be a link between 'asd4',
'phosphodiester', and 'colitis'.
I found no specific references to ASD4 and colitis however, so this
can only be considered wild conjecture.
Andy |