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Q: Prevalence/Incidence Ulcerative Colitis and Crohn's Disease in EU ( Answered 5 out of 5 stars,   1 Comment )
Question  
Subject: Prevalence/Incidence Ulcerative Colitis and Crohn's Disease in EU
Category: Health
Asked by: medmax-ga
List Price: $50.00
Posted: 10 Aug 2004 03:54 PDT
Expires: 09 Sep 2004 03:54 PDT
Question ID: 385781
What is the Prevalence and Incidence of Ulcerative Colitis and Crohn's
Disease in the largest 5 EU countries (UK, Germany, France, Italy,
Spain) and in Scandinavia (Sweden,Netherlands) ?
Answer  
Subject: Re: Prevalence/Incidence Ulcerative Colitis and Crohn's Disease in EU
Answered By: hummer-ga on 10 Aug 2004 08:21 PDT
Rated:5 out of 5 stars
 
Hi medmax,

The European Collaborative-study on Inflammatory Bowel Disease
(EC-IBD) seems to be the most respected and quoted study in recent
journals. You'll find the geographic results in Tables 4 & 5 in the
following pdf document.

"There are many epidemiological studies of the incidence and
prevalence of Crohn?s disease from Europe and America. The problem,
however, is that most of the early studies were retrospective. They
used different study designs (for example criteria of disease
definition, case ascertainment, or the time period of investigation)
and, with few exceptions (Aberdeen, Copenhagen, Leiden, Stockholm,
Uppsala) were based upon the experience of specialised medical
centres. The data they provided on the risk of disease in the
population were confusing, and in some respects unreliable."
"To overcome this problem, a group of clinicians and epidemiologists
in Europe carried out an epidemiological survey of the incidence of
inflammatory bowel disease (EC-IBD study) in 20 centres across Europe
prospectively and simultaneously between 1991 and 1994. The project
was a Concerted Action project of the Commission of the European
Communities with the aim of investigating the north-south gradient in
the risk of disease (incidence) using a standard protocol for disease
definition, case ascertainment and data analysis. The study was
conducted in the population of defined geographical areas ranging from
Reykjavic, Iceland in the north to Heraklion, Greece in the south, and
included regional case reviews and site visits for the quality control
of data."
"The results of this study are presented in Table 5. They show that
the highest age and sex adjusted incidence rate for Crohn?s disease
(per 100,000) was in Amiens (NW France) and Maastricht (the
Netherlands), followed by Oslo (Norway), Iceland, and Copenhagen
(Denmark). The lowest reported incidence was from Ioannina (NW
Greece). The incidence was broadly similar for men and women."
"However, recent epidemiological studies conducted in different
regions of France, using a common methodology, showed that the
prevalence and incidence of Crohn?s disease tended to be as high in
southern parts of that country as in the previously considered ?high
incidence areas? of the North"
Table 4. : Standardised incidence of CIBD in Europe and in France
Table 5 Incidence rates (/100,000/year) and numbers included in the
EC-IBD study 1991-94144.
http://europa.eu.int/comm/food/fs/sc/scah/out38_en.pdf

>>>>>>Additional Helpful Links

Crohn's disease epidemiology statistics:
http://alan.kennedy.name/crohns/epistats.htm 

The epidemiology of Crohn's disease:
http://alan.kennedy.name/crohns/epidem.htm

Crohn's disease	
30,000 to 40,000 (about 1 in every 1,600 people)
Ulcerative colitis	
100,000 (about 1 in 600 people)
http://www.ibdclub.org.uk/ibd_facts_ibd.html

* About 1 in 1600 people suffer from Crohn's disease.
* Some 3,000 new cases are diagnosed each year.
* Between 30,000 and 40,000 people in the United Kingdom live with the
condition. (Over 13,000 of these are members of NACC.)
* The most common age for diagnosis is between 15 and 25.
* Crohn's disease affects men and women equally.
* There is no national register of the number of people who have
Crohn's disease, although two extensive surveys are due to report
later this year. A population-based study in North East Scotland
(1992) showed that the number of new cases of Crohn's disease each
year in that area was rising and doubled between 1967 and 1987. In
1996, a study from South Glamorgan reported a doubling of the number
of children diagnosed with Crohn's disease between 1983 and 1993, and,
in 1999, a study of children in Scotland reported a 50% increase over
10 years in the incidence of Crohn's disease in children aged 16 or
under.
http://www.nacc.org.uk/actionweek_bgcrohns.asp

Crohn's disease
19.8/100,000
Ulcerative colitis
43.4/100,000 
http://alan.kennedy.name/crohns/research/epidem/spain3.htm

Number of People affected by colitis:
http://www.family-friendly-fun.com/321/number-of-people-affected-by-colitis.html

Crohn's disease epidemiology statistics:
http://www.family-friendly-fun.com/115/crohn-s-disease-statistics.html 

Epidemiology of IBD:
http://patients.uptodate.com/image.asp?file=gast_pix/epidem1.gif

Incidence and Prevalence of IBD:
http://patients.uptodate.com/image.asp?file=gast_pix/incide16.gif

"In the United States, in 1990, Crohn's disease cost between 1.0 and
1.2 billion dollars. Other countries with a high prevalence of Crohn's
disease are:- Canada, Sweden, Norway, Germany, United Kingdom,
Netherlands, Belgium, France, Switzerland, Austria, Spain, Portugal,
Greece, Italy, Ireland, Australia, New Zealand, and many countries of
Eastern and Central Europe. For a brief discussion of the worldwide
cost of Crohn's disease, see the page "The financial cost of Crohn's
disease."
http://alan.kennedy.name/crohns/welcome.htm

Who is affected by inflammatory bowel disease?
"The number of new patients diagnosed every year with ulcerative
colitis (the incidence of the disease) in the United States is 2 to 10
patients per 100,000 individuals. The incidence of Crohn's disease is
1 to 6 patients per 100,000 individuals.
The number of individuals with ulcerative colitis (the prevalence of
the disease) is estimated to be 35 to 100 patients per 100,000
individuals. The prevalence of Crohn's disease is 10 to 100 patients
per 100,000 individuals. Whereas the number of new cases of ulcerative
colitis has remained stable that of Crohn's disease is increasing."
http://www.cchs.net/health/health-info/docs/0300/0316.asp?index=4858 

"In Western Europe and in the USA, UC has an incidence of
approximately 6 to 8 cases per 100.000 populations and an estimated
prevalence of approximately 70 to 150 per 100.000 populations."
://www.google.ca/search?q=cache:74knI-6WwewJ:www.orpha.net/static/GB/ulcerative_colitis.html+Incidence+and+prevalence+of+ulcerative+colitis+in+europe&hl=en

I hope I've been able to find what you need. If not, or if you have
any questions, please post a clarification request and I'll be happy
to reply (I will be out for the rest of the day but will respond as
soon as possible).

Thank you,
hummer

Google Search Terms Used:

incidence prevalence cd uc italy germany spain 
Prevalence and Incidence of Ulcerative Colitis europe
ibd germany statistics incidence prevalence
ibd epidemiology country statistics incidence
crohn's france statistics prevalence incidence
crohn's france statistics prevalence
crohn's germany statistics prevalence
crohn's country statistics prevalence
Inflammatory bowel disease epidemiology europe
Inflammatory bowel disease epidemiology germany
Inflammatory bowel disease epidemiology statistics global
"Inflammatory bowel disease epidemiology" global
ibd country statistics prevalence
European Collaborative Study on Inflammatory Bowel Disease
Crohn's disease epidemiology statistics global
"Crohn's disease epidemiology statistics"
Incidence crohn's spain
Prevalence/Incidence Ulcerative Colitis spain
etc.

Request for Answer Clarification by medmax-ga on 10 Aug 2004 15:58 PDT
Hi hummer-ga,

thank you for the good work!Really apperciate it. Especially the
Epistats-link is great...

Is there any more info on Ulcerative Colitis readily available?

Kind regards,

medmax

Clarification of Answer by hummer-ga on 11 Aug 2004 09:41 PDT
Hi medmax,

Glad to hear you liked the Epistats, I did too. Unfortunately, I
haven't had much luck finding similar statistics. Here are my notes so
far, hopefully some of it will prove useful.

Recent time trends in the incidence of ulcerative colitis:
http://gut.bmjjournals.com/cgi/content/full/42/3/309/F2

What has happened to the incidence of ulcerative colitis?
http://gut.bmjjournals.com/cgi/content/full/42/3/309

>>>Worldwide

Crohn's Disease Worldwide
Prevalence: 10 - 70 cases / 100,000
Incidence: 0.5 - 6.3 cases / 100,000
http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijge/vol2n1/crohn.xml 

"Ulcerative colitis occurs world-wide, with low incidence in Eastern
Europe, Asia, Japan, and South America. Incidence in the UK is between
6.5 and 11 per 100,000 population. Jewish populations in the US and
Cape Town have a higher incidence than non-Jews or Ashkenazi Jews in
Israel."
http://www.hammersmithresearch.com/specialty/article.asp?Specialty=Digestion&art_id=175

"In Western Europe and in the USA, UC has an incidence of
approximately 6 to 8 cases per 100.000 populations and an estimated
prevalence of approximately 70 to 150 per 100.000 populations."
http://www.orpha.net/data/patho/GB/uk-UC.pdf

Worldwide Prevalence of Inflammatory Bowel Disease: 2000
http://www.hgsi.com/news/press/background_IBD.html



A new look at Crohn's disease [includes some interesting links, bottom of page]:
http://www.geocities.com/gastroyu/dec2000/AlicM.html

>>>Mortality
	
Map & Graph: Mortality: Ulcerative colitis (Top 100 Countries) 
http://www.nationmaster.com/graph-T/mor_ulc_col

Map & Graph: Mortality: Crohns disease (Top 100 Countries)
http://www.nationmaster.com/graph-T/mor_cro_dis_reg_ent

>>>France / Italy / Spain

Northern France 1997-99:
6.4/100,000 Incidence CD
3.5/100,000 Incidence UC
"Contrary to what has been reported in other countries in Northern
Europe, the incidence of CD increased by 23% in 12 years in Northern
France while that of UC decreased by 17% during the same period."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15138211&dopt=Abstract

Northern Italy
3.4 / 10 incidence CD
7.0 / 10 incidence UC
http://www.ncbi.nlm.nih.gov/entrez/quincidery.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8853254

Italy 1989 to 1992:
2.3/100,000 incidence CD
5.2/100,000 incidence UC 
http://ije.oupjournals.org/cgi/content/abstract/25/5/1044

Spain 
1994-1997
9.52/ incidence UC
5.95/ incidence CD
1997:
109.96 prevalence UC
 87.45 prevalence CD
http://scielo.isciii.es/scielo.php?pid=S0212-71992003000100002&script=sci_arttext&tlng=es

The Netherlands - CD:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=3498661&dopt=Abstract

>>>Some Other Countries

Estonia:
http://www.wjgnet.com/1007-9327/7/387.asp

Greece:
http://www.biomedcentral.com/1471-230X/2/1

India:
http://www.indegene.com/Gas/FeatArt/indGasFeat6.html 

Israel:
http://www.blackwell-synergy.com/links/doi/10.1111/j.1572-0241.2000.01849.x/abs/

Singapore:
http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2000&volume=15&issue=6&spage=622

Yugoslavia: 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=1800402&dopt=Abstract
http://www.mzos.hr/svibor/3/01/039/rad_cc_e.htm

Please let me know what else you need. There is no limit to the number
of clarifications you can post - the important thing is that you get
the information you need. I realize there is some extra data here that
you didn't request but I thought it wouldn't hurt to post it as long
as I was I was looking at it anyway - you never know when something
might contain a little nugget.

I'll look forward to hearing from you,
hummer
medmax-ga rated this answer:5 out of 5 stars
Great answer!I apperciate the follow up as well. Thank you Hummer !

Comments  
Subject: Re: Prevalence/Incidence Ulcerative Colitis and Crohn's Disease in EU
From: hummer-ga on 13 Aug 2004 04:56 PDT
 
Thank you for your thank you, medmax, I appreciate it. Interesting
topic. Sincerely, hummer

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