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Subject:
Penicillin
Category: Health Asked by: ehad2-ga List Price: $10.00 |
Posted:
14 Aug 2004 12:29 PDT
Expires: 13 Sep 2004 12:29 PDT Question ID: 387841 |
Could you explain the reasons for any changes in serum potassium when patients are taking penicillin? thank you |
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There is no answer at this time. |
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Subject:
Re: Penicillin
From: purkinje-ga on 14 Aug 2004 13:05 PDT |
Well, penicillin can come in the form of penicillin G potassium, for example, so if that is what you are using, then that would definitely cause hyperkalemia. The only other things I can think of is that the acidic carboxyl group and the metabolite penicilloic acid causes acidosis, and the kidney compensates for acidosis by the H+/K+ antiporter, thus also causing hyperkalemia. |
Subject:
Re: Penicillin
From: arsenic-ga on 14 Aug 2004 15:00 PDT |
"Hypokalemia may develop during therapy with certain antibiotics. Carbenicillin or other penicillin-like antibiotics exist as sodium or potassium salts of impermeant anions and promote kaliuresis because they increase net sodium excretion and because of an impermeant anion effect. Amphotericin B increases the permeability of luminal membranes to potassium and therefore promotes potassium secretion. Gentamicin produces potassium losses by unknown mechanisms." http://www.nursingceu.com/NCEU/courses/hypohyper/ |
Subject:
Re: Penicillin
From: ehad2-ga on 16 Aug 2004 20:00 PDT |
Thank you for the comments pertaining to this question. Though not designated "answers", the comments were extremely helpful and prompt. Elizabeth. |
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