How many people in the EU (EU5, Germany, France, Italy, Spain, UK)/or
if not possible worldwide suffer from SIADH (syndrome of inappropriate
secretion of ADH)-prevalence/incidence.

-What is it?
-Who has it?
-Who treats it?
-What is it treated with?

Hello Medmax~



WHAT IS SIADH?

SIADH (also called Dilutional hyponatremia or Schwartz-Bartter
syndrome) occurs when excessive levels of antidiuretic hormones (which
aid the kidneys and reserve water) occur in the body. With SIADH, the
body retains water and makes electrolytes (i.e. salts) in the body
decrease.


WHO HAS IT?

SIADH is typically caused by an underlying condition; therefore,
people who have SIADH also often have:

?Oat cell? or small cell lung cancer
Heart failure
A diseased hypothalamus (the part of the brain that helps produce hormones)
Pancreatic cancer
Prostate cancer
Hodgkin?s disease
Central nervous system disorders
Thymomas (a type of cancer in the chest)
Encephalitis (inflammation in the brain)
Brain tumors
Head trauma
Guillain-Barré syndrome (an affliction of the body?s nerves)
Myxedema (adult hypothyroidism)
Pneumonia
AIDS 

In addition, people taking certain drugs (including carbamazepine,
cyclophosphamide, vincristine, ecstasy [MDMA], neuroleptics, TCAs,
SSRIs [including anti-depressants], MAOIs, and NSAIDs) may develop
SIADH. Occasionally, children develop SIADH when they have meningitis.

Scientists aren?t sure how many people develop SIADH each year, but
feel that many cases go unreported. According to eMedicine, one study
claimed that 1% of the population may have SIADH, and 2.5% of
hospitalized patients may have it.  (?Excerpt from Syndrome of
Inappropriate Antidiuretic Hormone Secretion,? eMedicine:
http://www.emedicine.com/emerg/byname/syndrome-of-inappropriate-antidiuretic-hormone-secretion.htm
) These figures look at the U.S.A. only. Figures for the world or EU
are unstudied.

Symptoms of SIADH include:

Weight gain
Loss of appetite
Vomiting
Nausea
Thirst
Small amounts of urine
Headache
Muscle weakness
Muscle cramps or spasms
Personality changes
Fatigue
Irritability
Coma
Hallucinations
Confusion
Convulsions
Mental confusion


WHO TREATS IT?

SIADH may be diagnosed through a thorough physical examination by an
M.D. Blood tests are needed to confirm that SIADH is the problem.
These tests measure the body?s level of sodium and potassium chloride,
among other things.


WHAT IS IT TREATED WITH?

Generally, the first course of treatment is to restrict fluid intake
to either one liter or one?half a per day (or 30 to 75 percent of a
person?s normal fluid intake). In some instances, this fluid
restriction may need to be permanent.

Sometimes medication may be given to inhibit ADH (this is rarely done
with children due to side effects). A high salt, high protein diet may
also be recommended by a physician,.

Also, the underlying condition must be treated. Usually, once the
original cause is cured, SIADH goes away on its own.




You may wish to review the following articles:
?SYNDROME OF INNAPROPRIATE ADH SECRETION (SIADH)? at Neurological
Medicine Pocketbook,
http://www.uwo.ca/cns/resident/pocketbook/medicine/kidney/siadh.html

?Dilutional hyponatremia (SIADH)? at MedlinePlus, 
http://www.nlm.nih.gov/medlineplus/ency/article/000394.htm



If anything in this Answer is unclear, please don?t hesitate to
request a clarification before you rate it.

Kind regards,
Kriswrite


RESEARCH STRATEGY:
SIADH
://www.google.com/search?hl=en&lr=&ie=ISO-8859-1&q=SIADH&btnG=Search

"There are" "with SIADH"
://www.google.com/search?hl=en&lr=&ie=ISO-8859-1&q=%22There+are%22+%22with+SIADH%22

SIADH incidence
://www.google.com/search?hl=en&lr=&ie=ISO-8859-1&q=SIADH+incidence&btnG=Search

Thank you for your help.