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Q: questions about amorphous drugs ( Answered 3 out of 5 stars,   0 Comments )
Subject: questions about amorphous drugs
Category: Health > Medicine
Asked by: baz229-ga
List Price: $20.00
Posted: 20 Sep 2004 13:17 PDT
Expires: 20 Oct 2004 13:17 PDT
Question ID: 403879
whats so hard about making amorphous drugs?

why does one want them to be amorphous?

what are three top selling examples of amorphous drugs?

what are 3 situations where you want a drug to NOT be amorphous and
what are 3 top selling examples?

Clarification of Question by baz229-ga on 28 Sep 2004 16:29 PDT
any advice as to why this isn't getting a response??
Subject: Re: questions about amorphous drugs
Answered By: googleexpert-ga on 28 Sep 2004 19:30 PDT
Rated:3 out of 5 stars
Hi baz229,
Here's what I found in answer to some of your questions.

whats so hard about making amorphous drugs?

[1]"For most substances, the amorphous form is unstable, returning to
more stable crystalline form in a few minutes or hours."

why does one want them to be amorphous?
[2]"The beauty of amorphous forms is that they have a higher
dissolution rate and solubility than crystalline forms. However, very
few drugs are naturally amorphous."

Unfortunately, the only top selling amorphous drugs I found are:
Accupril/Accuretic, which makes over $300 Million in revenues
Worldwide.[3] is used to treat High Blood Pressure.[4]

Intraconazole, an Acne medication seems to use amorphous substances
in order to improve bioavailability or absorption.[6]

what are 3 situations where you want a drug to NOT be amorphous and
what are 3 top selling examples?

I think one situation that best sums up when a drug should NOT be amorphous
is when it does not dissolve easily in water.

[5]"Improvement of solubility and oral bioavailability of a poorly
water-soluble drug, TAS-301, by its melt-adsorption on a porous
calcium silicate....The drug existed in an amorphous state in the
product and hardly recrystallized even after storing at a stressed
condition (60C/80% RH for 3 days)."

[7]"Drugs that dissolve in fat (fat-soluble drugs), such as the
anesthetic drug halothane, tend to concentrate in fatty tissues"








Please let me know if you have anymore questions.
Thank you.


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amorphous (pfizer, glaxosmithkline..... and other pharmaceutical companies)
baz229-ga rated this answer:3 out of 5 stars
might be 4 but i haven't had time to thoroughly review or respond

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