Google Answers Logo
View Question
 
Q: questions about amorphous drugs ( Answered 3 out of 5 stars,   0 Comments )
Question  
Subject: questions about amorphous drugs
Category: Health > Medicine
Asked by: baz229-ga
List Price: $20.00
Posted: 20 Sep 2004 13:17 PDT
Expires: 20 Oct 2004 13:17 PDT
Question ID: 403879
whats so hard about making amorphous drugs?

why does one want them to be amorphous?

what are three top selling examples of amorphous drugs?

what are 3 situations where you want a drug to NOT be amorphous and
what are 3 top selling examples?

Clarification of Question by baz229-ga on 28 Sep 2004 16:29 PDT
any advice as to why this isn't getting a response??
Answer  
Subject: Re: questions about amorphous drugs
Answered By: googleexpert-ga on 28 Sep 2004 19:30 PDT
Rated:3 out of 5 stars
 
Hi baz229,
Here's what I found in answer to some of your questions.

whats so hard about making amorphous drugs?

[1]"For most substances, the amorphous form is unstable, returning to
more stable crystalline form in a few minutes or hours."


why does one want them to be amorphous?
[2]"The beauty of amorphous forms is that they have a higher
dissolution rate and solubility than crystalline forms. However, very
few drugs are naturally amorphous."

Unfortunately, the only top selling amorphous drugs I found are:
Accupril/Accuretic, which makes over $300 Million in revenues
Worldwide.[3] is used to treat High Blood Pressure.[4]

Intraconazole, an Acne medication seems to use amorphous substances
in order to improve bioavailability or absorption.[6]


what are 3 situations where you want a drug to NOT be amorphous and
what are 3 top selling examples?

I think one situation that best sums up when a drug should NOT be amorphous
is when it does not dissolve easily in water.

[5]"Improvement of solubility and oral bioavailability of a poorly
water-soluble drug, TAS-301, by its melt-adsorption on a porous
calcium silicate....The drug existed in an amorphous state in the
product and hardly recrystallized even after storing at a stressed
condition (60C/80% RH for 3 days)."


[7]"Drugs that dissolve in fat (fat-soluble drugs), such as the
anesthetic drug halothane, tend to concentrate in fatty tissues"


Sources
========
[1]http://www.howe.k12.ok.us/~jimaskew/chem/csolid.htm

[2]http://healthsci.otago.ac.nz/division/news/research_topics/rades.html

[3]http://www.pfizer.com/download/news/2004Q2_earnfin4.pdf

[4]http://www.drugs.com/PDR/Accuretic_Tablets.html

[5]http://www.aapspharmaceutica.com/search/view.asp?ID=4925 

[6]http://www.pharmcast.com/Patents/Yr2002/Feb2002/021202/6346533_itraconazole021202.htm

[7]http://www.merck.com/mmhe/sec02/ch011/ch011d.html


Please let me know if you have anymore questions.
Thank you.

-googleexpert

Search Strategy
==================
amorphous (pfizer, glaxosmithkline..... and other pharmaceutical companies)
baz229-ga rated this answer:3 out of 5 stars
might be 4 but i haven't had time to thoroughly review or respond

Comments  
There are no comments at this time.

Important Disclaimer: Answers and comments provided on Google Answers are general information, and are not intended to substitute for informed professional medical, psychiatric, psychological, tax, legal, investment, accounting, or other professional advice. Google does not endorse, and expressly disclaims liability for any product, manufacturer, distributor, service or service provider mentioned or any opinion expressed in answers or comments. Please read carefully the Google Answers Terms of Service.

If you feel that you have found inappropriate content, please let us know by emailing us at answers-support@google.com with the question ID listed above. Thank you.
Search Google Answers for
Google Answers  


Google Home - Answers FAQ - Terms of Service - Privacy Policy