Hello Pscope,
Below you will find information and links to articles and studies
regarding the statement Cetylpyridinium chloride kills the bacteria
that causes bad breath.
Cetylpyridinium Chloride
C21H38NCl
?Cetylpyridinium Chloride (CPC) is the active ingredient in Scope
mouthwash that has been shown to act as an antimicrobial.
Antimicrobials fight against oral bacteria and are responsible for
killing the germs that cause bad breath. It is also very effective in
preventing dental plaque.?
?Cetylpyridinium Chloride is a cationic quaternary ammonium compound.
It is found as a white powder and has a melting point of 80-83 degrees
Celsius. Cetylpyridinium Chloride is insoluble in acetone, acetic
acid, and ethanol, but is soluble under any other circumstances.?
College of Humanities and Social Sciences
http://www.cas.astate.edu/draganjac/cetylpyridiniumchloride.html
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?Cetylpyridinium chloride (CPC), a quaternary antiseptic, has been
found effective in controlling the accumulation of bacterial plaque
and the consequent gingivitis.?
? The drug has bactericidal activity against Gram-positive and, at
higher concentrations,against Gram-negative organisms. It has a good
activity against Candida albicans.?
Source: Original Research Paper (14 pages)
Design and characterization of mucoadhesive buccal patches containing
cetylpyridinium chloride
Full text available here:
http://public.srce.hr/acphee/nafee.pdf
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Cetylpyridinium chloride (CPC) is a quaternary ammonium compound,
cationic in nature, and has been shown to possess antimicrobial
activity against a number of oral bacteria (Smith et al, J Perio Res
26:422-428, 1991).
Mouthrinses containing CPC have been shown to be effective in the
control of dental plaque (Renton-Harper et al, J. Perio., 67:486-489,
1996).
Read the full txt of this article at the following link:
P&G Dental Resource Net
http://www.dentalcare.com/soap/products/research/pp2747.htm
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APPLICATIONS
?Cetylpyridinium Chloride is an antiseptic agent used alone or in
combination with other drugs for oral and throat care.?
GENERAL DESCRIPTION OF ANTISEPTIC AGENT
?Antiseptic agent is a substance which kills or inhibits the growth of
disease-causing bacteria and other microorganisms. It is essentially
nontoxic to to be applied to the skin or mucous membranes.!
?Cetylpyridinium chloride is used in oral rinses for cleaning mouth
and treating minor throat or mouth infections and teething problems?.
Chemical Land 21
http://www.chemicalland21.com/arokorhi/lifescience/phar/CETYLPYRIDINIUM%20CHLORIDE.htm
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?The compound cetylpyridinium chloride is sometimes included in the
formulation of mouthwashes. It serves as an antibacterial agent, thus
helping to control the number of anaerobic bacteria that are found in
a person's mouth.?
Animated-Teeth.com
http://www.animated-teeth.com/bad_breath/t5_halitosis_cures.htm
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Efficacy of a mouthrinse containing 0.05% cetylpyridinium chloride for
the control of plaque and gingivitis: A 6-month clinical study in
adults.
?The objective of this 6-month, double-blind, clinical study,
conducted following the American Dental Association (ADA) guidelines,
was to provide an assessment of the effectiveness of a newly developed
mouthrinse containing 0.05% cetylpyridinium chloride (CPC) for the
control of supragingival plaque and gingivitis.?
(. . .)
At both the 3- and 6-month study examinations, the CPC mouthrinse
group exhibited statistically significant less supragingival plaque
and gingivitis than did the control mouthrinse group. At the 6-month
examination, the magnitude of these differences met or exceeded 24%
for all 4 parameters measured (28.2% for Quigley-Hein Plaque Index,
63.4% for Plaque Severity Index, 24.0% for Loe-Silness Gingival Index,
and 66.9% for Gingivitis Severity Index).
DR Allen, et al. 1998 Compendum spec. issue, Vol. 19:20-26.
http://www.colgateprofessional.com/app/cop/docs/pdfs/clinicals/viadent_clinical_1.pdf
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Here are some links to a number of interesting studies:
The effects of a new mouthrinse containing chlorhexidine,
cetylpyridinium chloride and zinc lactate on the microflora of oral
halitosis patients: a dual-centre, double-blind placebo-controlled
study
Source:
Journal of Clinical Periodontology May 2003, vol. 30, no. 5, pp. 427-434(8)
?This study evaluated the microbial effects of a newly formulated
mouthwash (Halita®) on oral halitosis patients.?
Read the abstract here:
http://www.ingenta.com/isis/searching/Expand/ingenta?pub=infobike://mksg/cpe/2003/00000030/00000005/art00008
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Oral Microbiology and Immunology
Volume 19 Issue 5 Page 297 - October 2004
doi:10.1111/j.1399-302x.2004.00158.x
A simple approach to examine early oral microbial biofilm formation
and the effects of treatments.
Results:
?Rinsing with mouthrinses formulated with chlorhexidine,
cetylpyridinium chloride or triclosan/copolymer significantly
inhibited colonization (P < 0.05).?
Read the abstract here:
http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0902-0055&date=2004&volume=19&issue=5&spage=297
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Evaluation of Cetylpyridinium Chloride-Containing Mouthwashes Using In
Vitro Disk Retention and Ex Vivo Plaque Glycolysis Methods
S.J. Hunter-Rinderle, L.A. Bacca, K.T. McCaughlin,
D. Macksood, A.C. Lanzalaco, J. Parran, M.J. Doyle
http://www.jclindent.com/Abstracts/Rinderle_v844.html
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Oral Microbiol Immunol. 2004 Oct;19(5):297-302.
Sreenivasan PK, Mattai J, Nabi N, Xu T, Gaffar A.
Colgate-Palmolive Company, River Road, Piscataway, NJ, USA.
A simple approach to examine early oral microbial biofilm formation
and the effects of treatments.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15327641
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Search terms used:
CetylPyridinium Chloride
CetylPyridinium Chloride "bad breath?
I hope you find this information helpful!
Best regards,
Bobbie7 |
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