The term "zwitterionic" means that a molecule includes both a
positively charged and a negatively charged functional group at
biological pHs.
The zwitterionic piperazine referred to in the article you mentioned
is 4-(2 Hydroxyethyl)-1-piperazine ethane sulfonic acid, a zwitterion
buffer which is better known as HEPES. As mentioned in the article,
TVZ-7 was a code name assigned to this substance during the cancer
study described in the article.
Biotechnology grade HEPES can be obtained from BioShop Canada Inc:
BioShop Canada Inc: HEPES, Biotechnology Grade
http://www.bioshopcanada.com/detail.asp?Pin=HEP001
BioShop Canada Inc: HEPES, Sodium Salt, Biotechnology Grade
http://www.bioshopcanada.com/detail.asp?Pin=HEP002
BioShop Canada Inc: HEPES, 1M Sterile Solution
http://www.bioshopcanada.com/detail.asp?Pin=HEP003
Here you'll find ordering instructions for BioShop Canada:
BioShop Canada Inc: Ordering Information
http://www.bioshopcanada.com/order.asp
These additional sources of HEPES are not in Canada, but your
oncologist may be able to arrange international shipment. Note that
you can click the box beside the name of each firm, and the site will
direct an email inquiry to each supplier that you've selected:
BioSupplyNet
http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=1929
Regarding the TVZ-7 lymphocyte treatment that is mentioned elsewhere
on the Web, I do not think this is the same substance. The lymphocyte
treatment seems to be an "alternative medicine" therapy that is
combined with various herbal and nutritional supplements. TVZ-7
(HEPES) as referred to in the zwitterion article is provided by
biopharmaceutical firms, not by alternative medicine websites.
Here's a typical mention of the other TVZ-7, in context:
"The Green method includes components of Di Bella as well as other
components that have impressed me as being cancer treatments and
preventatives. Individualized to each person, it may contain:
The Green Diet
Aerobic Exercise
Vitamin C-oral
Vitamin C-intravenous
TVZ-7 lymphocyte immune component
Somatostatin-subcutaneous
Melatonin
Digestive enzymes (Wobe-Mugos)
Vitamin A
Vitamin D
Essiac herbal mixture"
Dr Jerry Green: The Green Method
http://www.drjerrygreen.com/green_method1.htm
It appears that Integrated Biologics Research Laboratories, which
conducted the study of zwitterionic piperazine in the article that you
cited, may have gone out of business. Although there is still a
website, it has not been updated since 2001, and many of the links are
broken:
Intergrated Biologics Research Laboratories
http://www.integratedbiologics.com/Research%20articles/articles.htm
One of the three authors of the cancer study, T. Ronald Theodore, was
an employee of Integrated Biologics Research Laboratories. If the
company has, in fact, gone out of business, I doubt that you'll be
able to reach him at the company address listed in the article
(Integrated Biologics Research Laboratories, Inc., 901 Main Street,
Osterville, Massachusetts 02655, USA), but it might be worth a try.
Since the other two authors' locations were cited only by city and
state, without listing their professional affiliations, I have not
been able to find contact information for them.
My Google search strategy:
Google Web Search: hepes canada
://www.google.com/search?hl=en&q=hepes+canada
Google Web Search: "4-(2 Hydroxyethyl)-1-piperazineethanesulfonic acid" canada
://www.google.com/search?hl=en&q=%224-%282+Hydroxyethyl%29-1-piperazineethanesulfonic+acid%22+canada
Google Web Search: tvz-7 cancer OR lymphocyte
://www.google.com/search?hl=en&q=tvz-7+cancer+OR+lymphocyte
I hope this is helpful. Please keep in mind that Google Answers is not
a source of authoritative medical advice; the material I've posted
above is for informational purposes, and should not be viewed as a
diagnosis nor as a substitute for the services of a medical
professional.
Best regards,
pinkfreud |
