sciencegal,
What an interesting topic this turned out to be! Fosmidomycin, as you
already know, is simply put, a phosphonic acid derivative, from a
species of streptomyces, which has antibacterial properties, and
apparently works as an anti-parasitic against p.faciparum. I don't
think this is an ingredient of Roundup, the commercial weed killer,
unless it goes by a completely different name. Permethrin
(3-phenoxybenzyl(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate)comes
from chrysanthymum flowers and is what is in Roundup (It is still
toxic!).
I found two sites where you CAN order fosmidomycin, better known to
researchers as FR-31564 :
http://www.probes.com/products/
They sell to Europe, Canada, and the US. You will, of course need an
account.
The second site that sells fosmidomycin is Cambridge BioScience.
Their site states you must be in the UK or Ireland. You could call
+44 (0)1223 316855 and see if they have a manner of selling out of
the country, if necessary. There is also an online contact form in the
left column of the page. It is worth a try!
http://www.bioscience.co.uk/productinfo.asp?Catalogue_Number=F-23103
I could locate no studies, protocols, or paprers about this topic with
the name of Hashimoto, but will list below all that I did find.
An abstract which mentions briefly how fosmidomycin is derived from
fermenting broth of Streptomyces lavendulae, by Okuhara M, Kuroda Y,
Goto T, Okamoto M, Terano H, Kohsaka M, Aoki H, Imanaka H.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=PubMed&doptcmdl=Citation&term=J+Antibiot[TA]+AND+33[VI]+AND+24[PG]+AND+1980[DP]
Some pharmokinetics in an orderable abstract by Murakawa T, Soneoka
K, Konishi T
http://www.ncbi.nih.gov/htbin-post/Entrez/query_old?uid=4066075&form=6&db=m&Dopt=b
On the chemical structure of fosmidomycin
http://www.probes.com/servlets/structure?item=23103
An abstract discussing the effects on the P. falciparum parasite
http://www.ncbi.nih.gov/htbin-post/Entrez/query_old?uid=10477522&form=6&db=m&Dopt=b
Another orderable abstract on the biosynthesis of fosmidomycin by
Mueller C, Schwender J, Zeidler J, Lichtenthaler HK.
http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11171210&dopt=Abstract
A wee bit more, look for the second topic on the page;
http://www.probes.com/lit/bioprobes34/section14.html
This site, while missing some of it's graphics, briefly discusses the
effects of fosamidomycin on P.falciparum.
http://www.biologie.uni-hamburg.de/lehre/bza/molnews/malaria/malaria.htm
Another abstract on the pharmokinetics of fosmidomycin as an
antibiotic in rats and dogs.
http://www.ncbi.nih.gov/htbin-post/Entrez/query_old?uid=7067725&form=6&db=m&Dopt=b
An abstract on the synergystic effects of fosmidomycin and other
antibiotics.
http://www.ncbi.nih.gov/htbin-post/Entrez/query_old?uid=7181471&form=6&db=m&Dopt=b
Back in the days of covered wagons when I was in school, I had an
instructor who almost succeded in fooling me into thinking I was
looking at a p.falciparum, schizont (?) form. He had switched our
plasmodium slides with babesia slides! (In actuality, the only reason
I suspected something was amiss was the poor condition of the babesia
slides! We recently had had a patient in-house with p.falciparum, and
those slides were new and in good condition!)
Hope this helps you out. I will continue to search for Hashimoto's
protocol.
Best regards,
crabcakes |
Clarification of Answer by
crabcakes-ga
on
24 Jul 2002 22:08 PDT
sciencegal-
I have searched and searched without finding a syhthesis protocol for
fosmidomycin. It has been my experience that pharmaceutical companies
as well as independent researchers fiercely guard their newly
discovered drug data. Since Jomaa Pharmaka is still researching the
efficacy and possible side effects of this drug, the chances of
finding it's synthesis are very slim. Are you certain you want the
synthesis of fosmidomycin and not the isoprenoid enzymes? I am
including another link below, for the synthesis of isoprenoid
enzymes.(Just in case)
I can still find nothing with the name of "Hashimoto". Do you have a
first name? Date of publication? Country of publication?
This site led me to the pathway of isoprenoid synthesis, which is
present in malaria parasites. The use of fosmidomycin inhibits the
path of these iosprenoid synthsis, just discovered in 1998.
http://www.jomaa-pharmaka.de/sites_english/start.php3?nav_code=ca
The pathway schematatics of isoprenoid synthesis are found here:
http://www.jomaa-pharmaka.de/sites_english/inhalt_english/abb_stoffwechselwege_e.htm
For a newly published report, from the Turkish Medline site (in
English) on fosmidomycin, read below. This site mentions the Jomaa
Pharmaka company, actively involved in research and development of
this new anti-malarial.
http://www.infeksiyon.org/Detail.asp?ctg=5&Article=644
The Nature MEdicine site also discusses fosmidomycin here:
http://www.nature.com/nm/special_focus/malaria/researchnews/mrb1.html
In the original question you asked for vendors where you could
purchase fosmidomycin. I supplied two, and I was wondering if you have
investigated these.Unless you own or work for a large pharmaceutical
laboratory, wouldn't it be best to purchase the fosmidomycin from a
laboratory that can certify the quality of the drug, especially if you
are intending to use it for your own research? If you were to
synthesize your own research drugs, you would have to prove HOW you
synthesized and quality controlled the drug for your own research to
be valid.
I will be happy to furthur research the Hashimoto paper, if you could
kindly get me more information. Numerous searches have yielded nothing
to link fosmidomycin and Hashimoto.
Please advise.
crabcakes
search terms:
Hashimoto
fosmidomycin
FR-31564
fosmidomycin protocol sysnthesis
malaria
streptomyces
and various permutations of the terms.
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