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Subject:
life destroyed by psychotic depression, med side effects making things worse
Category: Health Asked by: tmapj2-ga List Price: $2.00 |
Posted:
13 Feb 2006 23:44 PST
Expires: 15 Mar 2006 23:44 PST Question ID: 445538 |
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There is no answer at this time. |
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Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: probonopublico-ga on 13 Feb 2006 23:56 PST |
I am so sorry to hear of your condition and I hope that someone who knows about these things can make some helpful suggestions. Regretfully, this is not within my experience but please do not give up hope as I am sure that someone will be along shortly. Bryan |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: frde-ga on 14 Feb 2006 04:23 PST |
Checking out mifepristone it seems to be a progesterone inhibitor that is used for inducing abortions. It looks as if it has some fairly nasty side effects. Are you really sure that this is what you are after ? If you are fairly young and female, then your symptoms could be aggravated by a hormone imbalance, I'm no expert but know of a couple of cases. Often when people are diagnosed as depressed, they have a very good reason for being depressed, in other words 'depression' can be a symptom, and in my experience medics can irresponsibly provide drugs to tackle the symptom rather than tackle the cause. Mis-prescribed drugs can make things a lot worse, for example prescribing anti-epileptics to treat chronic pain. One turns into an incompetent zombie. Do you know what is at the root of your problems ? Being disabled is pretty unpleasant, it gives one little control over ones environment - being physically unable to cope is ... depressing - could it be that ? Have you looked at alternative therapies like homeopathy and accupuncture ? Homeopathy might be a load of nonsense, but a visit to a homeopathist is a lot less depressing than visiting a psychologist. I know that accupuncture can have astonishing effects, in my case, not those intended - there are quite a lot of things out there that are ill-understood, but less 'depressing' than conventional drug related medicine. This is a very public web site, so I suggest that you are careful what you say. However, I recommend that you look into the root of the real problem, then find other people who have been through it. Good Luck. |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: probonopublico-ga on 15 Feb 2006 00:42 PST |
Where do you live? Not your full address; just the State or Town would help. |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: tmapj2-ga on 15 Feb 2006 03:25 PST |
rockford illinois |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: jenny03-ga on 24 Feb 2006 20:38 PST |
It breaks my heart to read your story. I am 23 and I had my second episode of depression at the age of 21. I also had psychotic depression and nothing had seemed to help me get better until about half a year of trying medicines. I had lost all hope, BUT my psychiatrist put me on Risperdal and a high dose of effexor, 525mg. My doctor left me on the Risperdal for around 4 months and I continue to take effexor everyday. About half a year ago, I was able to decrease my effexor to 450mg and I am doing well. These medicines have saved my life and allowed me to regain my previous functioning. Please do not give up and please find a psychiatrist who might try other possibilities for you. My psychiatrist explained to me that no other current antidepressant would have worked, because our serotonin receptors have a max at which they are saturated and it is the fact that effexor also works on norepinephrine that allows this medicine to add additional benefits at higher doses. With the high dose of effexor, the benefits of the medicine come from targeting a large percentile of norepinephrine in addition to the saturated serotonin receptors. Does this make any sense? In other words, my doctor said that without this medicine, he would have had to augment antidepressants and antipsychotics with lithium or he would have had to try ECT on me. Please ask your psychiatrist about this combination, because effexor is currently the only antidepressant that can have additional benefits on severe depression at high doses. Please email me back if you have any questions. I wish you the best and pray that you get better in the near future. Please keep hope in knowing this is a possibility. |
Subject:
Bipolar depression almost ended my life.
From: frozen444-ga on 25 Feb 2006 07:27 PST |
If you or anyone you care about is tormented by clinical depression and none of the medications seem to help, you need to read this. Widespread ignorance regarding the endogenous opioid-depression-opioid connection, combined with the ruthless drug prohibition laws, sent me on a trip through hell and back. This ignorance also came within an inch of ending my life. If I can save someone from going through this hell by just explaining a few scientifically proven facts, I need to do it. Tormented by depression and nothing seems to help? You're not alone. Zoloft, Paxil, Lexapro, Effexor, Wellbutrin, Ativan, Xanax, Klonopin... You've tried two or three of these. They were supposed to help you feel better- but you just didn't! Sound familiar? Did you happen to notice that opioids like oxycodone and hydrocodone are the only substances capable of making you feel normal? Depression can result from a deficiency/over reuptake of serotonin, norepinephrine, or dopamine. Depression can also result from a deficiency /over reuptake of your endogenous opioids (endorphins/dynorphins/enkephalins). Watch TV for a couple hours and you'll probably see quite a few antidepressant commercials. The cruel joke is that every single one of those commercials is just pitching yet another serotonin/dopamine/norepinephrine re-uptake inhibitor product. If your depression results from an endogenous opioid deficiency, none of those products can help you. While common medical orthodoxy remains for some reason fixated on seratonin/norepinephrine/dopamine over-reuptake as the standard cause of nearly all depression, reality says otherwise. Every person has naturally occurring chemicals in their brain called endogenous opioids. They are endorphins, dynorphins and enkephalins. These endogenous opioids are very properly named, as they are (molecularly) nearly identical to real opioids like heroin or oxy. Some people have a natural deficiency of these vital chemicals, and have no choice but to consume opioids from an external source in order to feel 'normal'. This is from the website of an American clinic with branches in three cities: ( http://www.thepainmanagementcenter.com/english/buprenorphine/clinical.htm ) "Underproduction or over-removal (severe re-uptake) of these endogenous opioids can be the cause of many psychiatric disorders ranging from Bipolar Personality disorders to major depressive disorders that often times manifest themselves in severe drug abuse. Unbeknownst to them, these patients use opioid medications either illicit or pharmaceutical because they are compelled to attempt to replace the endorphins, dynorphins, and enkephalins (endogenous opioids) that naturally occur in their systems at insufficient levels." A clinical trial conducted at Harvard Medical School in 1995 ( http://www.drugbuyers.com/freeboard/showflat.php?Cat=0&Number=196682 ) demonstrated that a majority of treatment-refractory, unipolar, nonpsychotic, major depression patients could be successfully treated with an opioid called Buprenorphine, even after dozens of other (non-opioid) medications had failed to provide these patients with any measure of relief. Some of these patients even endured electroshock therapy, which didn't help either. Currently, governmental prohibition laws prohibit the overt use of buprenorphine as an antidepressant in the United States. If you suffer from this condition, your physician isn't going to tell you to urgently seek out opiates- let alone prescribe any. While many doctors are aware of the fact that numerous refractory depression patients can only be helped by opioids, an M.D. could lose his license, assets, and freedom by trying to save your life. If you lack the knowledge that opioids can help you- or simply lack a contact to score opioids illegally, you'll likely suffer a miserable, suicidal existence. Notch up another brilliant success in the government's 'War On Drugs'. Fortunately, there's a way out. It's even technically legal. Buprenorphine has been proven to be highly effective in treating refractory depression resulting from an endogenous opioid deficiency. In order to prescribe it, an M.D. must first obtain special permission from the prohibition enforcement goons. But once he/she undergoes an 8-hour training course and files the necessary paperwork with the ruling regime, a doctor can prescribe buprenorphine pills to 'treat an opiate addiction problem'... Even if you don't really have one. For many, an oxycontin dependency isn't a problem they need to overcome, but rather a solution to the nightmare of major refractory depression which plagues them every waking hour. However, buprenorphine is safer, cheaper, and far more easily obtained than other opioids- and it works. Buprenorphine partially binds to your µ- opioid receptor, which could just be all you really need to eliminate those feelings of crippling depression. In order to find scientific papers and other evidence of the endogenous opioids-depression-opioids connection, you can visit the only web site I know of, which is solely devoted to this cause: http://www.opioids.com Every year, over 30,000 depressed Americans commit suicide. The fate of millions of additional depression patients is far worse - they live. Many tried seeking medical treatment, but were given the same old crappy serotonin/dopamine/norepinephrine reuptake inhibitor products. No opioids. Buprenorphine could have saved most of them, but ignorance killed them. |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: tmapj2-ga on 02 Mar 2006 04:30 PST |
where did the guy go that had information on how to get on mifepristone :(:(:(:( pls come back |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: lostinmyhead-ga on 17 Mar 2006 15:00 PST |
I have had problems my whole life and still do, I research a lot and will until I find something that will make me stable. I find most Medical "Professionals" don't know any more than I do; so research. I didn't know what you were talking about the "mifepristone" so I googled it and look at this website http://www.fda.gov/cder/drug/infopage/mifepristone/ KEEP LOOKING. What about the Buprenorphine? I don't know anything about it but am going to research. |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: hedonicone-ga on 27 Mar 2006 18:59 PST |
I'm very familiar with mifepristone and aware of it's usefullness in treating PSD. Right now it is in 3rd phase trials and has been given fast track status by the FDA for treating PSD. There are clinical trials being conducted all over the US and Europe right now and they will continue for the next year. I would first go to clinicaltrials.gov and see if there is one in your area. The brand name of the drug is Corlux (mifepristone), and Corcept Pharmeceuticals owns the rights to it and is paying for the studies. So far, it has shown to be very effective in treating PSD(over 50%)with very few and only minor side effects. A study of Corlux in treating Bipolar Disorder is also underway and in phase 2 trials. If you don't find a study in your area, let me know. |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: ni42-ga on 04 Apr 2006 08:42 PDT |
Take a look at this site: http://www.crazymeds.org/ It's written by people who have been on the med-go-round many, many times. There is also a forum - you might try asking your question there, as well. I haven't found any mention of mifepristone on Crazy Meds, but somebody might know. At the very least, you will find people who can relate to you. Also, there may still be other options for you - there are many, many meds out there. There is a page specifically about buprenorphine, and tramadol (a psuedo-opioid). |
Subject:
Re: life destroyed by psychotic depression, med side effects making things worse
From: dre19731212-ga on 14 Jul 2006 12:34 PDT |
Hello, I am also looking for mifepristone to recover my HPA axis. Have you already found a way to get it? I saw this: http://www.abortion-pill-online.com/ but I am not sure this is a legitimate source. Do you know? Please anyone: let me know if you know a legitimate source and post it here or mail me (stompetower@gmail.com). I have had OSA (obstructive sleep apnea) all my life and according to scientific studies mifepristone can help me. My HPA axis is in a wrong state of equilibrium and mifepristone can get me out there. I suffer a lot from it. |
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