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| Subject:
testing positive for cocaine
Category: Miscellaneous Asked by: jvf1234-ga List Price: $10.00 |
Posted:
14 Feb 2006 19:54 PST
Expires: 16 Mar 2006 19:54 PST Question ID: 445932 |
I keep on reading that amoxicillian can cause a false positive for cocaine. If this is true what will be the ppm level range concentration,on a 500mg capsule taken twice daily for three days. |
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| There is no answer at this time. |
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| Subject:
Re: testing positive for cocaine
From: hardtofindbooks-ga on 15 Feb 2006 18:41 PST |
If you are asking for information on the pharmacokinetics of amoxicillin: according to the Prescription Products Guide 1992. Aust. Pharmaceutical Publishing Co Ltd (print) "The half life of Amoxil is 61.3 minutes with normal renal function and in the absence of renal function 16-20 hours. Amoxil is excreted in the urine both unchanged and as penicilloic acid. About 75% of a 1 g dose is excreted in the urine in 6 hours in the presence of normal renal function (60% is biolog ically active and 15% is penicilloic acid). However about 32% of a 3 g dose is excreted via the urine as the biologically active component in 8 hours (by which time most of the urinary excretion is complete). This proportional difference in the amount excreted from the different doses reflects a lack of linearity between doses and extent of absorption with a levelling off at higher doses of oral amoxycillin. Excretion of Amoxil can be delayed by concurrent administration of probenecid thus prolonging its therapeutic effect. Arnoxil is not highly protein bound, being only 17% proteinbound in serum as measured by ultrafiltration or equilibrium dialysis. Orally administered doses of 250 mg and 500 mg amoxycillin result in average peak serum levels one to two hours after administration of 5.0 mcg/mL and 6.6-10.8 mcg/mL respectively. Delectable serum levels of amoxycillin are present 8 hours after ingestion of a single dose." according to http://www.rxlist.com/cgi/generic/amox_cp.htm "Orally administered doses of 250-mg and 500-mg amoxicillin capsules result in average peak blood levels 1 to 2 hours after administration in the range of 3.5 mcg/mL to 5.0 mcg/mL and 5.5 mcg/mL to 7.5 mcg/mL, respectively." |
| Subject:
Re: testing positive for cocaine
From: hardtofindbooks-ga on 19 Feb 2006 19:37 PST |
Hi again, Just to correct a couple of unproofed OCR errors in my previous post 'Arnoxil' should of course read 'Amoxil', and while serum levels may indeed be 'delectable', the word should have been 'detectable'. Thanks. |
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