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Q: Drugs in the pipeline ( No Answer,   1 Comment )
Question  
Subject: Drugs in the pipeline
Category: Health
Asked by: cwiley8668-ga
List Price: $20.00
Posted: 13 Jan 2005 10:54 PST
Expires: 12 Feb 2005 10:54 PST
Question ID: 456701
I'm looking for Drugs in all phases (including pre-clinical)of the
pipeline for Erectile Dysfunction, US & International. Please list out
drug name with company link and phase.
Thanks.

Clarification of Question by cwiley8668-ga on 13 Jan 2005 14:21 PST
I need some clarification, your research from Medscape (a site I use
often) showed Vivus' avanafil, a US based pharma company as the only
drug world wide, in the pipeline for ED?  What about International?

However Pharmaceutical Research and Manufacturers of America (PhRMA:
http://www.phrma.org/newmedicines/, they listed 6 in various phases. 
Pharma only covers USA and I put this question out there looking for
both the US and International markets.  My research on DIALOG Web also
provided me a list of drugs in the pipeline but I wasn?t sure if they
were US or EU based.

Request for Question Clarification by voila-ga on 14 Jan 2005 06:44 PST
No, actually avanafil was the only drug I was aware of without doing
any research as it's the next likely Viagra/Levitra/Cialis-equivalent
to be marketed.

I did have a few minutes to check Medscape for ED research trends,
though, and posted what I found.

Oftentimes researchers will add a comment or a clarification to gauge
the level of search skills, breadth of knowledge on a subject, and
elicit a specific number qualifier a customer may have in mind as a
satisfactory answer.  The more we know about your requirements, the
better we will be able to tailor our research and return only new
information to you.

From the Answers Help and Tips page: How to get a better answer to your question.

#3  Summarize your own findings in the question. When writing your
question, please include a summary of any information that you may
have already found online about your question including specific links
if they are pertinent or have proven to be dead-ends. This will help
Researchers understand where to begin their research for you.
http://answers.google.com/answers/help.html#B 

Hopefully, with this additional information, one of the full-time
researchers will take an interest in your question, since I work here
sporadically and in very short time increments.

Perhaps you also located Palatin's PT-141 intranasal peptide for
treatment of male and female sexual dysfunction?
http://www.palatin.com/html/products/pt_141.aspx

Please note that your question will only be answered and your credit
card charged when someone posts in the "answer" section and you are
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I hope this information is helpful,
V
Answer  
There is no answer at this time.

Comments  
Subject: Re: Drugs in the pipeline
From: voila-ga on 13 Jan 2005 13:16 PST
 
I only know of Vivus' avanafil at the moment.  I believe it's in Phase
2 clinical trials.

From a Medscape article:

Combination Therapies

    * Apomorphine and sildenafil
    * Apomorphine and x-adrenoceptor (x-AR) antagonists
    * Nitrosylated x-AR antagonists

New Areas to Target

    * Central nervous system:

      Melanocortin receptors
      Oxytocin and oxytocin receptors
      Growth hormone-releasing peptide receptors
      5-hydroxytryptamine receptors

    * Peripheral targets:

      Guanylyl cyclase activators
      Rho-kinase

Andersson KE, Hedlund P. New directions for erectile dysfunction
therapies. Int J Impot Res. 2002;14(suppl 1):S82-S92.

And some interesting stats from Pharmacy Times:

An estimated 150 million men worldwide have some degree of ED, and
more than twice that many are expected to be affected by 2025.  Given
that age-related hormonal changes contribute to the overall
prevalence, the impact of ED has particular implications for the
United States, where the population is expected to grow increasingly
older in the coming years.
http://www.pharmacytimes.com/article.cfm?ID=1286

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