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| Subject:
cardiovascular drugs
Category: Health > Medicine Asked by: doctorchou2-ga List Price: $2.00 |
Posted:
15 Jan 2005 15:10 PST
Expires: 16 Jan 2005 07:29 PST Question ID: 457845 |
What drug, or class of drug, is a negative chronotrope but NOT a negative inotrope? If there is none, which drug comes close to it? |
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| Subject:
Re: cardiovascular drugs
From: pinkfreud-ga on 15 Jan 2005 15:15 PST |
Here's a mention of such a drug: "...dofetilide is a positive inotrope and negative chronotrope in the rat." http://www.ingentaconnect.com/content/rpsgb/jpp/2002/00000054/00000005/art00014 |
| Subject:
Re: cardiovascular drugs
From: pinkfreud-ga on 15 Jan 2005 15:18 PST |
Another: "Digoxin is both a positive inotrope and a negative chronotrope." http://www.vetgo.com/cardio/concepts/concsect.php?conceptkey=61 |
| Subject:
Re: cardiovascular drugs
From: pinkfreud-ga on 15 Jan 2005 15:21 PST |
For a class of drugs, try "Cardiac Glycosides." "Cardiac Glycosides Mechanism of Action Increased myocardial contractility Augments vagal tone, increasing diastolic filling Decreased conduction between the atria and the ventricles Drug Effects Positive inotrope Negative chronotrope Negative dromotrope" http://healthsci.clayton.edu/NURS326/drugs.htm |
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