What happens when I take both Zocor and Biaxin together? What will
happen to me and how soon?  Will it be fatal? Can the effects be
reversed? How do you reverse the effects of the 2 medicines.  If I was
taking ZOCOR for an extended period of time (80mg daily), and I took
500mg of BIAXIN twice daily, how many days could I take that
medication (Biaxin)before the effects were no longer reversable.  I am
a 74 year old woman. I am 5' 3" and weigh 125lbs. My kidneys are at
50% because of damage caused by Arthritis medication.

This is not professional advice. You should contact a doctor about
this question. More than likley you can even call your local hospital
and inquire about this information.

Possible food and drug interactions when taking this medication
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Zocor tends to enhance the effects of the blood-thinning drug Coumadin
and the heart medication Lanoxin. Combining it with the following
drugs increases the chance of muscle damage:

Amiodarone (Cordarone) 
Clarithromycin (Biaxin) 
Clofibrate (Atromid-S) 
Cyclosporine (Sandimmune, Neoral) 
Erythromycin (PCE and others) 
Fenofibrate (Tricor) 
Gemfibrozil (Lopid) 
Itraconazole (Sporanox) 
Ketoconazole (Nizoral) 
Nefazodone (Serzone) 
Nicotinic acid or niacin (Niaspan) 
Protease inhibitors (used in the treatment of HIV), including
Agenerase, Crixivan, Fortovase, Invirase, Norvir, and Viracept
Verapamil (Calan) 

If you are taking Zocor with any of these drugs (or with large
quantities of grapefruit juice) alert your doctor immediately at the
first sign of muscle pain or weakness. If you need to take
erythromycin, Biaxin, Nizoral, or Sporanox, the doctor may temporarily
take you off Zocor.

http://www.healthsquare.com/newrx/zoc1500.htm