I'm interested in a career change.
Would like to pursue computer/internet work-from-home opportunities.
Can you suggest a starting point for locating the most reliable businesses?

You can run many many companies from your home with a computer,
broadband and phones.

For phones, get yourself roadrunner internet (cable broadband) and
setup yourself a Vonage : http://www.vonage.com account for phone
service. You can do almost anything with this phone service and is
great for home business because you can add toll free service to your
line(s) for 5 dollars a month. Very good for the small business home
user. Plus it's the best and cheapest way to setup a home business.
With a business account you get a free fax line too.

2nd, Pick what you want to do. Do you want to sell products? Have a
online news site and make money from ads? Do you want to make
websites? Database work? That would require school hours. How about
Stocks? Many companies today outsource business to people that work
from home. Such as billing, tech support, cold calling, sales etc..  
Find what you want to do with your business. You can even sell cars
from a virtual car lot. Almost anything can make money if done right.

I have a friend that sells clocks online and makes 100k/year from it.
He's now moving into other things with his business. Anything you can
think of you can do.

I work from home working with public companies as outsourced Investor
Relations. Works well.

Good luck.

It might be important if neosin-ga can tell him how he can get contact
details of companies outsource business to people work from home

Here is a site feed that is addressing the same question you ask it
may be of some help to you.
http://feeds.feedburner.com/WhatTheHeckWorks

If you are really serious about a Computer/Internet Biz you can run from home
I have a suggestion for you. Click on the link I have provided below
to view a prerecorded presentation explaining how to profit online and
what you rally need to be profitable on the Internet.
 
http://webcast1.worldprofit.com/recordingarchives/videoarchive/video.cfm?filename=6168-297.flv

If you find this is something that interest you and would like to
learn more, feel free to cantact me at ivan_roche@comcast.net

Good luck to you in your persue of financial independence.