Hi barbgram,
It seems to appear that glucosamine-chondroitin is safe with most
medications, including yours. I can find no evidence, on reliable
medical sites, that show glucosamine-chondoitin is harmful to take
with your currentmedications. However, always advise your doctor of
any supplements, herbals, vitaimins and homeopathic remedies you may
be taking when s/he is prescribing medication for you.
The problem I do find is not an interaction from your current
medications and glucosamine-chondroitin, but the Welbutrin taken with
Estratest. Wellbutrin and Estratest, taken together, has caused some
patients to have suffered seizures. Also, grapefruit juice should be
avoided by persons taking Estratest, as the juice can excessively
raise the levels of estrogen in your bloodstream.
?BUPROPION HYDROCHLORIDE (WELLBUTRIN SR extended-release tablet)
and METHYLTESTOSTERONE (ESTRATEST tablet)
Taking a SYSTEMIC STEROID and BUPROPION may cause you to have a seizure.
If you take a systemic steroid and bupropion you may be more likely to
have a seizure. Some example of systemic steroids are dexamethasone
(Decadron(R)), methylprednisolone (Medrol(R)), and and prednisone
(Deltasone(R)). If you are not sure if you are taking a systemic
steroid medication, ask your doctor or pharmacist. Your doctor may
change the medicines you take. Call your doctor right away for any
signs of a seizure. 1. You have muscle stiffness or jerking. 2. You
have a sudden loss of bladder control (causing you to wet yourself).
3. You pass out.?
Estratest is an esterified form of estrogen. ?ESTERIFIED ESTROGENS
(ESTRATEST tablet) and GRAPEFRUIT JUICE
Treatment with ESTROGEN and GRAPEFRUIT JUICE may result in higher
amounts of estrogen in your blood, which may increase the risk of
certain side effects.
If you take grapefruit juice and also take estrogen, you may have
symptoms of too much estrogen in your blood. Tell your doctor about
all the medications you take, including herbs and vitamins. Your
doctor may change the amounts of medicines you take. Call your doctor
right away for any of the following problems. 1. Your blood pressure
is higher than normal. 2. You are retaining fluid (you feel bloated).
3. You have abdominal pain. 4. You have a severe headache. 5. You have
breast tenderness. 6. You are bleeding from your vagina. 7. You get
yeast infections. 8. You feel nauseous or are vomiting. 9. You are
short of breath. 10. You are having chest pain.?
?BUPROPION HYDROCHLORIDE (WELLBUTRIN SR extended-release tablet) and ETHANOL
Drinking ALCOHOL (or taking any product containing alcohol) while
being treated with BUPROPION may result in an increased risk of
seizures.
Drinking alcohol while being treated with bupropion is not
recommended. Call your doctor right away for any of the following
problems. 1. You are confused. 2. You have changes in mental
awareness. 3. You have sudden muscle spasms. 4. You have seizures.?
Please note: The preceding information is an educational aid only. It
is not intended as medical advice for individual conditions or
treatments. Talk to your doctor, nurse or pharmacist before following
any medical regimen to see if it is safe and effective for you.
These warnings were found by clicking the link below, and selecting
?Drug Checker? from the menu in the left hand corner.
http://www.aurorahealthcare.org/misc/askanexpert/_hidden/display.asp?id=687&Expert=142&cat=687&type=pharmacist
?Glucosamine and chondroitin sulfate are substances found naturally in
the body. Glucosamine is a form of amino sugar that is believed to
play a role in cartilage formation and repair. Chondroitin sulfate is
part of a large protein molecule (proteoglycan) that gives cartilage
elasticity.
Both glucosamine and chondroitin sulfate are sold as dietary or
nutritional supplements. They are extracted from animal tissue:
glucosamine from crab, lobster or shrimp shells; and chondroitin
sulfate from animal cartilage, such as tracheas or shark cartilage.?
?Children, women who are pregnant, and women who could become pregnant
should not take these supplements. They have not been studied long
enough to determine their effects on a child or on a developing fetus.
Because glucosamine is an amino sugar, people with diabetes should
check their blood sugar levels more frequently when taking this
supplement.
If you are taking chondroitin sulfate in addition to a blood-thinning
medication or daily aspirin therapy, have your blood clotting time
checked more often. This supplement is similar in structure to the
blood-thinning drug heparin, and the combination may cause bleeding in
some people.
If you are allergic to shellfish, consult your doctor before deciding
to take glucosamine. In most cases, however, allergies are caused by
proteins in shellfish, not chitin, a carbohydrate from which
glucosamine is extracted.
You can try the supplements along with your current medications for
six to eight weeks. If you don't experience any difference in your
symptoms within a few months, you probably will not get any relief
from using the supplements.?
http://www.arthritis.org/conditions/alttherapies/Glucosamine.asp
?Glucosamine and chondroitin seem to be, in safety studies that have
been done in the United States, basically as safe as taking placebo.
Reported side effects include; stomach upset, gastrointestinal upset
and skin rash, but these are infrequent and if they were to occur the
supplement could be discontinued.
Glucosamine should not be taken by people with a history of allergy to
shellfish. Levels of the blood-thinning medication, coumadin, may be
affected by chondroitin sulfate. Recent reports have shown that
glucosamine might elevate insulin levels in diabetics.?
http://www.medicinenet.com/script/main/art.asp?articlekey=14559
"Talk to your doctor. Although many people believe that traditional
physicians will dismiss their interest in supplements, many doctors
are actually quite open to complementary treatments. However, these
supplements are not appropriate for all forms of arthritis or for all
people. Diabetics and pregnant women, for example, should be
especially cautious.
2. Don't stop your current regimen of diet, exercise, medication or
other therapies. The effectiveness of these treatments is proven, and
nutritional supplements should remain just that – complementary to
your good health practices. You may need to take the supplements for a
couple of months before you see any results, which makes it all that
more important to continue your current treatments.
3. Do some research first. Find out about the supplement you are
considering buying. Are there any side effects? Will it interact with
your current medication? Write to the manufacturer and ask for
documentation that supports their claims. For additional information
on glucosamine, check the web site for the National Institute's of
Health (www.nih.gov).
4. Stick with a reputable manufacturer. Because these products are not
regulated, consumers are on their own. Even products labeled
"standardized" don't meet outside standards, just internal ones set by
the manufacturer. Standards can vary among manufacturers, so avoid
brand names you don't know.
5. If anything does go wrong and you experience some adverse side
effects, report them to your doctor quickly and stop taking the
product. Remember that any supplement potent enough to help is
probably also strong enough to harm if taken inappropriately. "
http://orthoinfo.aaos.org/fact/thr_report.cfm?Thread_ID=219&topcategory=Knee
"Asthma exacerbation associated with glucosamine-chondroitin supplement"
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12463294&dopt=Abstract
You CAN take grapefruit juice with Wellbutrin, in spite of rumors to
the contrary. However, Estratest should not be taken with grapefruit
juice, nor should Lipitor.
?In researching this question, I could find no mention that there is
an interaction between Wellbutrin (bupropion) and grapefruit juice.
However, there are other medications that may interact with grapefruit
juice (some of which are antidepressants). So if you are ever started
on any new medications, you should always let your physician or
pharmacist know that you drink a lot of grapefruit juice and have them
check for any potential interactions. I hope this information has been
of some help?enjoy your grapefruit juice without fear.?
http://www.aurorahealthcare.org/misc/askanexpert/_hidden/display.asp?id=687&Expert=142&cat=687&type=pharmacist
Lipitor:
?? Tell your doctor and pharmacist if you are allergic to
atorvastatin or any other medications.
? Tell your doctor and pharmacist what prescription and
nonprescription medications, vitamins, nutritional supplements, and
herbal products you are taking. Be sure to mention any of the
following: antifungal medications such as itraconazole (Sporanox) and
ketoconazole (Nizoral); cimetidine (Tagamet); digoxin (Lanoxin);
erythromycin (E.E.S., E-Mycin, Erythrocin); medications that suppress
the immune system such as cyclosporine (Neoral, Sandimmune); oral
contraceptives (birth control pills); other cholesterol-lowering
medications such as fenofibrate (Tricor), gemfibrozil (Lopid), and
niacin (nicotinic acid, Niacor, Niaspan); and spironolactone
(Aldactone). Your doctor may need to change the doses of your
medications or monitor you carefully for side effects.
? tell your doctor if you drink large amounts of alcohol and if you
have or have ever had liver or kidney disease.
? tell your doctor if you are pregnant, plan to become pregnant, or
are breast-feeding. If you become pregnant while taking atorvastatin,
stop taking atorvastatin and call your doctor immediately.
Atorvastatin may harm the fetus.
? if you are having surgery, including dental surgery, tell the
doctor or dentist that you are taking atorvastatin.
? if you have a severe infection, surgery, an injury, low blood
pressure, or seizures while taking atorvastatin, talk to your doctor
about stopping the medication for a while.
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a600045.html
http://www.drugs.com/lipitor.html
Lisinopril:
?Tell your doctor and pharmacist if you are allergic to lisinopril,
enalapril (Vasotec), benazepril (Lotensin), captopril (Capoten),
fosinopril (Monopril), moexipril (Univasc), perindopril (Aceon),
quinapril (Accupril), ramipril (Altace), trandolapril (Mavik), or any
other medications.
Tell your doctor and pharmacist what prescription and nonprescription
medications, vitamins, nutritional supplements, and herbal products
you are taking. Be sure to mention any of the following: aspirin and
other nonsteroidal anti-inflammatory medications (NSAIDs) such as
indomethacin (Indocin); diuretics ('water pills'); lithium (Eskalith,
Lithobid); and potassium supplements. Your doctor may need to change
the doses of your medications or monitor you carefully for side
effects.
Tell your doctor if you have or have ever had heart or kidney disease;
diabetes; lupus; scleroderma; or angioedema, a condition that causes
difficulty swallowing or breathing and painful swelling of the the
face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs.
Tell your doctor if you plan to become pregnant or are breast-feeding.
If you are having surgery, including dental surgery, tell the doctor
or dentist that you are taking lisinopril.
You should know that diarrhea, vomiting, not drinking enough fluids,
and sweating a lot can cause a drop in blood pressure, which may cause
lightheadedness and fainting.?
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a692051.html#side-effects
?Use caution when driving, operating machinery, or performing other
hazardous activities. Lisinopril may cause dizziness or drowsiness. If
you experience dizziness or drowsiness, avoid these activities and
notify your doctor. Also use caution when rising from a sitting or
lying position.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness
while you are taking lisinopril. Alcohol may further lower blood
pressure and increase drowsiness and dizziness when you are taking
lisinopril
Do not use salt substitutes or potassium supplements while taking
lisinopril except under the supervision of your doctor
http://www.drugs.com/MTM/lisinopril.html
http://www.drugs.com/lisinopril.html
?What drug(s) may interact with lisinopril?
?antiinflammatory drugs (NSAIDs, such as ibuprofen)
?hawthorn
?heparin
?lithium
?medicines for high blood pressure
?potassium salts
?water pills
Tell your prescriber or health care professional about all other
medicines you are taking, including non-prescription medicines,
nutritional supplements, or herbal products. Also tell your prescriber
or health care professional if you are a frequent user of drinks with
caffeine or alcohol, if you smoke, or if you use illegal drugs. These
may affect the way your medicine works. Check with your health care
professional before stopping or starting any of your medicines.?
http://www.drugdigest.org/DD/DVH/Uses/0,3915,390%7CLisinopril,00.html
?Interestingly, lisinopril and other ACE inhibitors were developed
from the venom of a poisonous Brazilian snake.?
?In general, lisinopril should not be taken with potassium supplements
or diuretics that conserve potassium, e.g., Dyazide, since blood
potassium levels may rise to dangerous levels.?
http://www.medicinenet.com/lisinopril/article.htm
Additional Information:
Starting on Page 32 of this protected document, is some interesting
information on glucosamine.
http://connections.lww.com/Products/koda-kimble/documents/PDFs/Ch03.pdf
Although no systematic studies have been done to assess the potential
of bupropion(Wellbutrin) to interact with other drugs, bupropion
should be used cautiously in patients receiving drugs that reduce the
threshold for seizures. Such drugs include prochlorperazine
(Compazine), chlorpromazine (Thorazine), and other antipsychotic
medications of the phenothiazine class. Additionally, persons who are
withdrawing from benzodiazepines (e.g. diazepam, Valium; alprazolam,
Xanax) are at increased risk for seizures.?
http://www.answers.com/main/ntquery?method=4&dsid=2222&dekey=Bupropion&gwp=8&curtab=2222_1
?In vitro studies indicate that bupropion is primarily metabolized to
the morpholinol metabolite (hydroxybupropion) by the cytochrome
P450IIB6 (CYP2B6) isoenzyme. Therefore, the potential exists for a
drug interaction between bupropion HCl and drugs that affect the
CYP2B6 isoenzyme (e.g., orphenadrine and cyclophosphamide). The
threohydrobupropion metabolite of bupropion does not appear to be
produced by the cytochrome P450 iosenzyme. Few systemic data have been
collected on the metabolism of ZYBAN following concomitant
administration with other drugs or, alternatively, the effect of
concomitant administration of ZYBAN on the metabolism of other drugs.
Animal data indicated that bupropion may be an inducer of
drug-metabolizing enzymes in humans. However, following chronic
administration of bupropion, 100 mg t.i.d. to 8 healthy male
volunteers for 14 days, there was no evidence of induction of its own
metabolism. Because bupropion is extensively metabolized, the
coadministration of other drugs may affect its clinical activity. In
particular, certain drugs may induce the metabolism of bupropion
(e.g., carbamazepine, phenobarbital, phenytoin), while other drugs may
inhibit the metabolism of bupropion (e.g., cimetidine). The effects of
concomitant administration of cimetidine on the pharmacokinetics of
bupropion and its active metabolites were studied in 24 healthy young
male volunteers. Following oral administration of two 150-mg ZYBAN
tablets with and without 800 mg of cimetidine, the pharmacokinetics of
bupropion and its hydroxy metabolite were unaffected. However, there
were 16% and 32% increases, respectively, in the AUC and Cmax of the
combined moieties of threohydro- and erythrohydro- bupropion.
Drugs Metabolized by Cytochrome P450IID6 (CYP2D6): Many drugs,
including most antidepressants (SSRIs, many tricyclics),
beta-blockers, antiarrhythmics, and antipsychotics are metabolized by
the CYP2D6 isoenzyme. Although bupropion is not metabolized by this
isoenzyme, bupropion and hydroxybupropion are inhibitors of the CYP2D6
isoenzyme in vitro. In a study of 15 males subjects (ages 19 to 35
years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily
doses of bupropion given as 150 mg twice daily followed by a single
dose of 50 mg desipramine increased the Cmax, AUC, and T½ of
desipramine by an average of approximately 2-, 5-and 2-fold,
respectively. The effect was present for at least 7 days after the
last dose of bupropion. Comcomitant use of bupropion with other drugs
metabolized by CYP2D6 has not been formally studied.
Therefore, co-adminstration of bupropion with drugs that are
metabolized by CYP2D6 isoenzyme including certain antidepressants
(e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine,
sertraline), antipsychotics (e.g., haloperidol, risperidone,
thioridazine), beta-blockers (e.g., metoprolol), and Type 1C
antiarrhythmics (e.g., propafenone, flecanide), should be approached
with caution and should be initiated at the lower end of the dose
range of the concomitant medication. If bupropion is added to the
treatment regimen of a patient already receiving a drug metabolized by
CYP2D6, the need to decrease the dose of the original medication
should be considered, particularly for those concomitant medications
with a narrow therapeutic index.?
http://www.answers.com/main/ntquery?method=4&dsid=2222&dekey=Bupropion&gwp=8&curtab=2222_1
****Please note, barbgram, I am not sure if you are taking lisinopril.
If you are not taking lisinopril, please request an Answer
Clarification,before rating, with the name and use of the drug you are
calling ?lisiop?, and I will respond ASAP. I can find no drug called
?lisiop?, but will gladly research this drug when we are certain of
the spelling and purpose of this medication.
Regards, crabcakes
Search Terms:
Wellbutrin + drug interactions
Wellbutrin + glucosamine chondroitin
glucosamine chondroitin + lipitor
glucosamine chondroitin + estratest
Estratest + drug interactions
Lisinopril + drug interactions
glucosamine chondroitin + Lisinopril
glucosamine chondroitin + side effects |
