For salbutamol the definition of a positive under the anabolic agent
category is a concentration in urine greater than 1000 nanograms per
millilitre
http://208.56.168.207/documents/1_IOCList2001-02EnL.htm
?Salbutamol levels below 1000 nanograms per millilitre require
therapeutic justification and/or examination by a medical panel. A
concentration of greater than 1000 nanograms per millilitre of
non-sulphated salbutamol is considered of anabolic nature and
constitutes a doping violation.?
Source: The Canadian Centre for Ethics in Sport
http://ace.acadiau.ca/sports/cis/drug_classification_advisory_note.pdf
WADA 2004 Prohibited List
?According to the World Anti-Doping Agency (WADA) 2004 Prohibited
List , all Beta-2-agonists are prohibited except formoterol,
salbutamol, salmeterol and terbutaline, which are permitted by
inhalation only to prevent and/or treat asthma and exercise induced
asthma/bronchoconstriction.?
?Despite granting of a TUE, an adverse analytical finding will be
considered when a concentration of Salbutamol (free plus glucuronide)
greater than 1000ng/ml is reported unless the athlete can demonstrate
the result was due to the therapeutic inhaled use of salbutamol.?
http://www.eirpharm.com/healthtips.php?g_id=9&g_name=Sports%20Medicine&id=106
The World Anti-Doping Agency (WADA) have launched The 2004 Prohibited List.
Some notable changes to the list include:
?Beta2-agonists were previously listed under stimulants have now been
recategorised separately. All Beta-2 Agonists are prohibited except
formeterol, salbutamol, salmeterol and terbutaline which are permitted
by inhalation only when used to prevent and/or treat excercise-induced
asthma/bronchoconstrition. Such use requires a Therapeutic Use
Exemption (TUE). The new code also states that "despite the granting
of a TUE, when the laboratory has reported a concentration of
salbutamol (free plus glucuronide) greater than 1000ng/ml, this will
be considered as an adverse analytical finding unless the athlete
proves that the abnormal result was the consequence of the therapeutic
use of inhaled salbutamol".
http://www.eirpharm.com/healthtips.php?g_id=9&g_name=Sports%20Medicine&id=116
?The World Anti-Doping Code, published by the World Anti-Doping Agency
(WADA), harmonises anti-doping regulations across all sports and in
all countries. This Code includes a list of substances and methods
which are prohibited in sport.
However, in recognition of the fact that some prohibited substances
may be necessary for legitimate medical treatment, the code permits
athletes and their physicians to apply for a Therapeutic Use Exemption
(TUE).
There are two types of TUE in the Code.
? Medical notification is required using an abbreviated TUE process to
apply to use (1) the inhaled beta-2-agonists, formoterol, salbutamol,
salmeterol and terbutaline and/or (2) glucocorticosteroids by
non-systemic routes, except dermatological preparations which are
permitted.
? If the athlete wishes to use any other substance or method on The
Prohibited List a standard TUE is required.
S3 All Beta-2-agonists are prohibited. As an exception formoterol,
salbutamol, salmeterol and terbutaline, when administered by
inhalation only to prevent/treat asthma and exercise induced
asthma/bronchoconstriction require an abbreviated TUE. Despite
granting of a TUE, an adverse analytical finding will be considered
when a concentration of Salbutamol (free plus glucuronide) greater
than 1000ng/ml is reported unless the athlete can demonstrate the
result was due to the therapeutic use of inhaled salbutamol.?
http://www.eirpharm.com/healthtips.php?g_id=9&g_name=Sports%20Medicine&id=124
?The anabolic nature of salbutamol above a concentration of 1000ng/ml has
been clearly expressed. Salbutamol levels below 1,000 nanograms per
millilitre require therapeutic justification and/or examination by a medical
panel. A concentration of greater than 1,000 nanograms per millilitre of
non-sulphated salbutamol is considered of anabolic nature and constitutes
a doping violation.?
http://www.uksport.gov.uk/images/uploaded/2003revisions.pdf
Search criteria:
salbutamol use in sports
I hope this is helpful.
Best regards,
Bobbie7 |
Request for Answer Clarification by
melbell-ga
on
29 Jan 2005 10:50 PST
all levels stated in answers are the levels in urine not blood as requested.
thanks
|
Clarification of Answer by
bobbie7-ga
on
29 Jan 2005 11:05 PST
I did not find any evidence of salbutamol levels in blood at the World
Anti-Doping Agency (WADA; however I will do further researcher and
hopefully will find the information for you.
Thank you for your patience.
Bobbie7
|
Clarification of Answer by
bobbie7-ga
on
29 Jan 2005 11:08 PST
Sorry for the typo, it should be research not researcher.
|
Clarification of Answer by
bobbie7-ga
on
29 Jan 2005 14:04 PST
Dear Melbell,
I?ve been searching all afternoon for the level of Salbutamol in blood
that is the limit in drug testing for sports. All the sports related
websites present figures for the limit of Salbutamol levels in urine.
For example:
The 2004 United States Anti-Doping Agency GUIDE to PROHIBITED SUBSTANCES
and PROHIBITED METHODS of DOPING states:
?Salbutamol concentration greater than 1000 ng/mL is a doping
violation (in- or out-of competition and with or without an
abbreviated TUE) unless the athlete can prove it is due to therapeutic
use by inhalation.? http://www.usantidoping.org/files/active/athletes/2004GuideBook.pdf
The USA Badminton (USAB), the recognized national governing body for
the sport of badminton in the United States states:
?For salbutamol, a concentration in urine greater than 1000 nanograms
per millilitre of non-sulphated salbutamol constitutes a doping
violation.?
http://www.usabadminton.org/docs/Annex_A_Jan_03.doc
From the Cricket Australia Anti-Doping Policy:
?For salbutamol the definition of a positive under the anabolic agent
category is a concentration in urine greater than 1000 nanograms per
millilitre.? http://www.viccricket.asn.au/page/anti_doping.html
The World Anti-Doping Agency (WADA), harmonises anti-doping
regulations across all sports and in all countries. This Code includes
a list of substances and methods
which are prohibited in sports.
They state that ?an adverse analytical finding will be considered
when a concentration of Salbutamol (free plus glucuronide) greater
than 1000ng/ml is reported unless the athlete can demonstrate the
result was due to the therapeutic use of inhaled salbutamol?
http://www.eirpharm.com/healthtips.php?g_id=9&g_name=Sports%20Medicine&id=124
I have reached a dead end here. Perhaps if you can give me a few more
details I will be able to locate additional information. Where did you
hear that the levels of Salbutamol are measured in the blood for
sports?
I look forward to your clarification.
Sincerely,
Bobbie7
|
Request for Answer Clarification by
melbell-ga
on
30 Jan 2005 09:55 PST
hello bobbie7
I will explain my postion to give a little idea of what i am doing. i
currently doing a research project into identifing salbutamol in blood
using screen printed carbon electrodes, with regards to testing in
sports. Most drugs i have looked at have levels for blood and
urine(they are always different), but so far I have be unable to find
a level for salbutamol in blood.
Hope this helps,
regards, Mel xx
|
Clarification of Answer by
bobbie7-ga
on
30 Jan 2005 10:25 PST
Hi Mel!
Thank you for your clarification.
I found a publication that might interest you.
Clean-up, detection and determination of salbutamol in human
urine and serum
http://pubs.rsc.org/ej/AN/2000/b000010h.pdf
I will resume my search but I'm not sure if I will be able to find the
exact information that you require.
If I don't, would you like me ask ask the editors to remove my answer?
That way another researcher can take a shot at your question and you
won't be charged for my answer.
Thanks again,
Bobbie7
|
Clarification of Answer by
bobbie7-ga
on
30 Jan 2005 18:13 PST
Hello again Mel,
I didn't find anthing relevant regarding the limit for the level of
salbutamol in blood so I decided to send off an email to the World
Anti-Doping Agency (WADA) requesting that information.
I will let you know as soon as they reply.
Regards,
Bobbie7
|
Clarification of Answer by
bobbie7-ga
on
31 Jan 2005 06:31 PST
Good Morning Mel,
Ann-Muriel Steff, Pharm.D., Ph.D., Research Manager of the World
Anti-Doping Agency kindly replied to my inquiry with the following
information.
Firstly, salbutamol levels are not measured in blood for anti-doping
purposes. Salbutamol is detected in urine only.
Secondly, salbutamol is a prohibited substance, so any level of
salbutamol detected in urine is a positive, unless the athlete has a
Therapeutic Use Exemption (TUE). If the athlete is taking INHALED
salbutamol, an ABBREVIATED TUE is sufficient, but the abbreviated TUE
will not be valid if the concentration found in urine is greater than
1000 nanograms/mL.
Contact Information:
Ann-Muriel Steff, Pharm.D., Ph.D.
Research Manager / Responsable de la recherche
World Anti-Doping Agency / Agence Mondiale Antidopage
Tel: + 1 514 904 8838
Mob: + 1 514 945 8806
Fax: + 1 514 904 8774
E-mail: ann-muriel.steff@wada-ama.org
Web: www.wada-ama.org
I hope this helps!
|
Request for Answer Clarification by
melbell-ga
on
08 Feb 2005 09:32 PST
Hi,
Thanks for the help, didn't really answer the question, but give me a
few useful pointers.
Many Thanks
Regards Mel xx
|
Clarification of Answer by
bobbie7-ga
on
08 Feb 2005 10:23 PST
Dear Mel,
Although I didn't give you the exact information you needed, I'm glad
that my findings were helpful.
Thank you for understanding.
Sincerely,
Bobbie7
|
,
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