Pharmacology definition - oral clearance vs. systemic clearance
Category: Health > Medicine
Asked by: zoegardner-ga
List Price: $5.00
30 Jan 2005 13:40 PST
Expires: 01 Mar 2005 13:40 PST
Question ID: 465933
What is the difference between the pharmacology terms "oral clearance" and "systemic clearance," referring to the metabolism of drugs in the human body? (i.e. "The oral clearance of midazolam was significantly increased during St. John's wort administration, but the systemic clearance of midazolam was unchanged.")
Re: Pharmacology definition - oral clearance vs. systemic clearance
Answered By: pafalafa-ga on 30 Jan 2005 14:33 PST
Zoegardner-ga, Systemic clearance refers to the clearance rate of a drug after it's been administered intravenously. Oral clearance, in contrast, refers to the rate of clearance of drugs administered orally. The two rates can be quite difference, since oral administration usually does not result in 100% delivery of the drug beyond the stomach. I hope this answers your question at the level of detail that you needed. However, please don't rate the answer until you are comfortable that you have all the information you need. If anything else is required, just post a Request for Clarification to let me know. All the best, pafalafa-g search strategy: None. Used my personal knowledge of toxicology to answer the question.
rated this answer:
Just the answer I was looking for, thanks.
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