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Q: Pharmacology definition - oral clearance vs. systemic clearance ( Answered 5 out of 5 stars,   0 Comments )
Subject: Pharmacology definition - oral clearance vs. systemic clearance
Category: Health > Medicine
Asked by: zoegardner-ga
List Price: $5.00
Posted: 30 Jan 2005 13:40 PST
Expires: 01 Mar 2005 13:40 PST
Question ID: 465933
What is the difference between the pharmacology terms "oral clearance"
and "systemic clearance," referring to the metabolism of drugs in the
human body?  (i.e. "The oral clearance of midazolam was significantly
increased during St. John's wort administration, but the systemic
clearance of midazolam was unchanged.")
Subject: Re: Pharmacology definition - oral clearance vs. systemic clearance
Answered By: pafalafa-ga on 30 Jan 2005 14:33 PST
Rated:5 out of 5 stars

Systemic clearance refers to the clearance rate of a drug after it's
been administered intravenously.

Oral clearance, in contrast, refers to the rate of clearance of drugs
administered orally.

The two rates can be quite difference, since oral administration
usually does not result in 100% delivery of the drug beyond the

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search strategy:  None.  Used my personal knowledge of toxicology to
answer the question.
zoegardner-ga rated this answer:5 out of 5 stars
Just the answer I was looking for, thanks.

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