Bortezomib is a dipeptide of boronic acid used in the treatment of
multiple myeloma. Once reconstituted in 0.9% saline water, it lasts
about 8 to 12 hours due to inherent instability of bortezomib
molecule. How one can increase the life of reconstituted bortezomib?
How long reconsituted bortezomib will last if kept refrigerated in
total darkness?

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Clarification of Question by rock10-ga on 31 Jan 2005 21:02 PST

Please note that bortezomib molecule is photosensitive and the
lyophilized drug product is formulated with mannitol to increase it
stability. The package insert says that after the drug product has
been reconstituted, it would not last more than 8 to 12 hours. I would
like to know what could be done to increase the life of reconstituted
bortezomib.

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Clarification of Question by rock10-ga on 31 Jan 2005 21:24 PST

At 25 degree celsius, reconstituted bortezomib lasts about 8 hours.
The question is asking if we could increase its lifespan by lowering
its temperature.

Why do you need to reconstitute the vial for longer than 8 hours? 
Also, the stability of the reconstituted solution at 15 degrees
Celsius is still 8 hours (recommended max) in the vial.
Lowering the temperature will still have no effect on the relative short lifespan.

Ryan - The stability period in all the package inserts by drug
manufacturers is highly understated. A number of drugs can last for
several days after reconstitution, however, manufacturers still
recommend only a few hours. Perhaps they want to play extremely safe.
If reconstituted drug could be used for a longer period (for my
treatment) then I could save a lot of money by using the same
reconstituted drug for my 2nd dose.