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Q: Side effects of Premarin ( Answered 3 out of 5 stars,   2 Comments )
Subject: Side effects of Premarin
Category: Health > Women's Health
Asked by: johnor-ga
List Price: $30.00
Posted: 23 Feb 2005 12:44 PST
Expires: 25 Mar 2005 12:44 PST
Question ID: 479559
In article



Recent studies have confirmed an increased rate of heart attack,
stroke, and dangerous blood clots among women taking estrogen or
estrogen combinations for 5 years.

Quantitatively, what is this increased rate?

Who did this study?

Who can I contact for more info?

I'm willing to pay $30.00 for this info.
Subject: Re: Side effects of Premarin
Answered By: techtor-ga on 23 Feb 2005 18:51 PST
Rated:3 out of 5 stars
Hello johnor,
I have looked around the Internet and found the information that I list below.

The first is an unlikely site to find the information, though it may
have what you are looking for: >> Horses Go on the Auction Block After Premarin Sales Decline:
- "Following the 2002 report by the Women's Health Initiative that
found relatively modest increases in risk for some health problems
among those who took Premarin, sales of the drug dropped like a stone.
The WHI study found that women taking the drugs had a 41 percent
increased risk of strokes, a 29 percent increased risk of heart
attacks, and a 26 percent increased risk of breast cancer."

It appears that the study was done by the WHI or Women's Health Initiative. 


Prempro injury - causes of life threatening Prempro injury:
- This is a website showing a study on the effects of the drug
Prempro, probably a brand of Premarin, posted by the Monheit Law Firm.
"Evidence is clear that Prempro injury side effects and other estrogen
progestin combinations can actually harm perfectly healthy women.
Women taking Prempro have a 29 percent higher risk of heart attack, 41
percent higher risk of Prempro stroke, and 26 percent higher risk of
breast cancer. Prempro was also found to double the risk of dementia
and Alzheimer's disease."

Here is a more general study on hormone usage contributing to heart
attack probability:

Hormones Double Risk of Heart Attack - You
- "The report, an analysis of data from the Initiative, is published
today in the New England Journal of Medicine.
The researchers found that a woman's risk of a heart attack rises by
81 percent in the first year of hormone therapy. It levels off, so
that after 5.6 years the length of the study the increased risk is 24

Here is the website of the Women's Health Initiative:

Google Search terms used:
premarin heart attack side effects
premarin heart attack risk 
premarin risk percent
women's health initiative

I hope this has been a helpful answer. If you need something
clarified, or have a problem with the answer, do please post a Request
for Clarification before rating and I'll come back to you as soon as I
can. Thank you.
johnor-ga rated this answer:3 out of 5 stars

Subject: Re: Side effects of Premarin
From: dr_bob-ga on 02 Mar 2005 09:56 PST
the above studies are quite one sided.

to be honest, you should look up all of the data.

I don't get paid for this, so I'm not going to do it for you.

Will get you started.  

You might also consider Raloxifene and the STAR trial.
Subject: Re: Side effects of Premarin
From: dr_bob-ga on 02 Mar 2005 10:05 PST

about middle of the page is a reference to a washinton post article. 
I believe the numbers quoted are correct.  That is the absolute risk
was quite minimal.

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