Interested in finding out the connection between pH and healthy
connective tissue.  Connective tissue has semiconductor properties and
pH supposedly has something to do with the way it functions in this
regard.  Fill me in, please...

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Request for Question Clarification by tox-ga on 20 Mar 2005 20:34 PST

Hello,

I would be glad to help answer your question if you would specify a
type of connective tissue (ie, loose, dense, blood, bone, cartilage,
adipose, etc)

Cheers,

tox-ga

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Clarification of Question by jat-ga on 25 Mar 2005 14:26 PST

re: your request for further clarification, the answer is "it really
doesn't matter much" (with the exception of adipose tissue, which I
would categorize primarily as "fat").  How about this, for starters:
any collagenous tissue.  Collagen protein structure seems to exhibit
piezo-electric qualities (including that of bones) as well as
liquid-crystalline properties.  I'm wondering what role pH plays in
enabling the connective tissue matrix to maintain optimum health.  I'm
assuming that an "alkaline" pH is more to be desired.  But why?  And,
in what way does pH effect the semiconductor properties of the
protein/collagenous/connective tissue?  Hope I haven't further muddied
the waters here...

Hello,

I would be glad to help answer your question if you would specify a
type of connective tissue (ie, loose, dense, blood, bone, cartilage,
adipose, etc)

Cheers,

tox-ga

re: your request for further clarification, the answer is "it really
doesn't matter much" (with the exception of adipose tissue, which I
would categorize primarily as "fat").  How about this, for starters:
any collagenous tissue.  Collagen protein structure seems to exhibit
piezo-electric qualities (including that of bones) as well as
liquid-crystalline properties.  I'm wondering what role pH plays in
enabling the connective tissue matrix to maintain optimum health.  I'm
assuming that an "alkaline" pH is more to be desired.  But why?  And,
in what way does pH effect the semiconductor properties of the
protein/collagenous/connective tissue?  Hope I haven't further muddied
the waters here...

I am thinking that the pH is not that important. However, I would
concentrate on the pKa or pKb of the compartmentalised target. i.e.
Clemson investigators used crystals [implanted in the femur following
a controlled separatrion] in the 1970s to facilitate osteoclst
proliferation in a.caninus. pKa and pKb were important from a piezo
electric basis. My experience is founded in using liposomes to deliver
naked oligonucleotide in environments that have various acid/base
values. Make a normal curve and move on....i do not think I helped
interesting question though.....Is not there a collection of
information on this in monoclonal antibody research? i would think
that there is....

Hello,

Not 100% sure if this is what you mean but pH = pKa + log ([A-]/[HA]).
Eg if pH=pKa+2 =>acid is almost 100% deprotonated and therefore the
electronic properties of the acid medium changes.

Get right up me if I'm wrong, this is my first comment made with my shiny new Mac.

Hey dude, don't call me dude.